
葉漢根
教授
一般心臟學
心導管檢查
複雜冠狀動脈介入性心導管
慢性阻塞性病變
- 聯絡電話
- 電子郵件信箱
han.gung@msa.hinet.net
Hon-Kan Yip received his M.D. degree from Kaohsiung Medical University (Taiwan) in 1991. He completed his residency training in the Department of Internal Medicine at Chang Gung Memorial Hospital – Kaohsiung Medical Center (Taiwan) and was promoted Attending Cardiologist there in 1996. He is now a professor at the institute. His clinical expertise is in interventional cardiology, while his major research interests include cardiovascular diseases, inflammation, stem cell, and other studies in the field of translational medicine.
Selected Recent Publications (Pubmed Search)
- Chen YT, Chen KH, Sung PH, Yang CC, Cheng BC, Chen CH, Chang CL, Sheu JJ, Lee FY, Shao PL, Sun CK, Yip HK*. Extracorporeal shock wave markedly alleviates radiation-induced chronic cystitis in rat. Am J Transl Res. 2018 Mar 15;10(3):1036-1052.
- Lee FY, Sun CK, Sung PH, Chen KH, Chua S, Sheu JJ, Chung SY, Chai HT, Chen YL, Huang TH, Huang CR, Li YC, Luo CW, Yip HK*. Daily melatonin protects the endothelial lineage and functional integrity against the aging process, oxidative stress and toxic environment and restores blood flow in critical limb ischemia area in mice. J Pineal Res. 2018 Mar 23:e12489.
- Sung PH, Lee FY, Tong MS, Chiang JY, Pei SN, Ma MC, Li YC, Chen YL, Wu CJ, Sheu JJ, Lee MS, Yip HK*. The Five-Year Clinical and Angiographic Follow-Up Outcomes of Intracoronary Transfusion of Circulation-Derived CD34+ Cells for Patients With End-Stage Diffuse Coronary Artery Disease Unsuitable for Coronary Intervention-Phase I Clinical Trial. Crit Care Med. 2018 Feb 19.
- Sung PH, Lee FY, Lin LC, Chen KH, Lin HS, Shao PL, Li YC, Chen YL, Lin KC, Yuen CM, Chang HW, Lee MS, Yip HK*. Melatonin attenuated brain death tissue extract-induced cardiac damage by suppressing DAMP signaling. Oncotarget. 2017 Dec 12;9(3):3531-3548.
- Yang CC, Chen YT, Chen CH, Chiang JY, Zhen YY, Yip HK*. Assessment of doxorubicin-induced mouse testicular damage by the novel second-harmonic generation microscopy. Am J Transl Res. 2017 Dec 15;9(12):5275-5288.
- Lu HI, Lee FY, Wallace CG, Sung PH, Chen KH, Sheu JJ, Chua S, Tong MS, Huang TH, Chen YL, Shao PL, Yip HK*. SS31 therapy effectively protects the heart against transverse aortic constriction-induced hypertrophic cardiomyopathy damage. Am J Transl Res. 2017 Dec 15;9(12):5220-5237.
- Lin PY, Chen CH, Wallace CG, Chen KH, Chang CL, Chen HH, Sung PH, Lin KC, Ko SF, Sun CK, Chang HW, Shao PL, Lee MS, Yip HK*. Therapeutic effect of rosuvastatin and propylthiouracil on ameliorating high-cholesterol diet-induced fatty liver disease, fibrosis and inflammation in rabbit. Am J Transl Res. 2017 Aug 15;9(8):3827-3841.
- Chen CH, Chen YL, Sung PH, Sun CK, Chen KH, Chen YL, Huang TH, Lu HI, Lee FY, Sheu JJ, Chung SY, Lee MS, Yip HK*. Effective protection against acute respiratory distress syndrome/sepsis injury by combined adipose-derived mesenchymal stem cells and preactivated disaggregated platelets. Oncotarget. 2017 Jul 17.
- Sung PH, Chiang HJ, Lee MS, Chiang JY, Yip HK*, Yang YH*. Combined renin-angiotensin-aldosterone system blockade and statin therapy effectively reduces the risk of cerebrovascular accident in autosomal dominant polycystic kidney disease: a nationwide population-based cohort study. Oncotarget. 2017 Jun 27;8(37):61570-61582.
- Chen YT, Wallace CG, Yang CC, Chen CH, Chen KH, Sung PH, Chen YL, Chai HT, Chung SY, Chua S, Lee FY, Ko SF, Lee MS, Yip HK*. DPP-4 enzyme deficiency protects kidney from acute ischemia-reperfusion injury: role for remote intermittent bowel ischemia-reperfusion preconditioning. Oncotarget. 2017 Jul 4;8(33):54821-54837.
- Sheu JJ, Ali HEE, Cheng BC, Chiang HJ, Sung PH, Chen KH, Yang CC, Chen YT, Chiang JY, Lin PY, Chua S, Chai HT, Chung SY, Sun CK, Yip HK*. Extracorporeal shock wave treatment attenuated left ventricular dysfunction and remodeling in mini-pig with cardiorenal syndrome. Oncotarget. 2017 May 30; 8(33):54747-54763.
- Wang CC, Tseng CC, Chang HC, Huang KT, Fang WF, Chen YM, Yang CT, Hsiao CC, Lin MC, Ho CK, Yip HK*. Circulating microparticles are prognostic biomarkers in advanced non-small cell lung cancer patients. Oncotarget. 2017 Jun 6;8(44):75952-75967.
- Lee FY, Chen KH, Glenn Wallace C, Sung PH, Sheu JJ, Chung SY, Chen YL, Lu HI, Ko SF, Sun CK, Chiang HJ, Chang HW, Lee MS, Yip HK*. Xenogeneic human umbilical cord-derived mesenchymal stem cells reduce mortality in rats with acute respiratory distress syndrome complicated by sepsis. Oncotarget. 2017 Jul 11;8(28):45626-45642.
- Wang CJ, Cheng JH, Huang CY, Hsu SL, Lee FY, Yip HK*. Medial tibial subchondral bone is the key target for extracorporeal shockwave therapy in early osteoarthritis of the knee. Am J Transl Res. 2017 Apr 15;9(4):1720-1731.
- Yuen CM, Yeh KH, Wallace CG, Chen KH, Lin HS, Sung PH, Chai HT, Chen YL, Sun CK, Chen CH, Kao GS, Ko SF, Yip HK*. EPO-cyclosporine combination therapy reduced brain infarct area in rat after acute ischemic stroke: role of innate immune-inflammatory response, micro-RNAs and MAPK family signaling pathway. Am J Transl Res. 2017 Apr 15;9(4):1651-1666.
- Lee FY, Zhen YY, Yuen CM, Fan R, Chen YT, Sheu JJ, Chen YL, Wang CJ, Sun CK, Yip HK*. The mTOR-FAK mechanotransduction signaling axis for focal adhesion maturation and cell proliferation. Am J Transl Res. 2017 Apr 15;9(4):1603-1617.
- Sun CK, Chen CH, Chang CL, Chiang HJ, Sung PH, Chen KH, Chen YL, Chen SY, Kao GS, Chang HW, Lee MS, Yip HK*. Melatonin treatment enhances therapeutic effects of exosomes against acute liver ischemia-reperfusion injury. Am J Transl Res. 2017 Apr 15;9(4):1543-1560.
- Sung PH, Yang YH, Chiang HJ, Chiang JY, Chen CJ, Liu CT, Yu CM, Yip HK*. Risk of aortic aneurysm and dissection in patients with autosomal-dominant polycystic kidney disease: a nationwide population-based cohort study. Oncotarget. 2017 Mar 17;8(34):57594-57604.
- Chen KH, Chen CH, Wallace CG, Chen YT, Yang CC, Sung PH, Chiang HJ, Chen YL, Chua S, Yip HK*, Cheng JT*. Combined therapy with melatonin and exendin-4 effectively attenuated the deterioration of renal function in rat cardiorenal syndrome. Am J Transl Res. 2017 Feb 15;9(2):214-229.
- Lee MS, Lee FY, Chen YL, Sung PH, Chiang HJ, Chen KH, Huang TH, Chen YL, Chiang JY, Yin TC, Chang HW, Yip HK*. Investigated the safety of intra-renal arterial transfusion of autologous CD34+ cells and time courses of creatinine levels, endothelial dysfunction biomarkers and micro-RNAs in chronic kidney disease patients-phase I clinical trial. Oncotarget. 2017 Jan 27. doi: 10.18632/oncotarget.
- Lin PY, Lee FY, Wallace CG, Chen KH, Kao GS, Sung PH, Chua S, Ko SF, Chen YL, Wu SC, Chang HW, Yip HK*, Shao PL. The therapeutic effect of rosuvastatin and propylthiouracil on ameliorating high-cholesterol diet-induced rabbit aortic atherosclerosis and stiffness. Int J Cardiol. 2017 Jan 15; 227:938-949.
- Sung PH, Chiang HJ, Yang YH, Chen CJ, Chiang JY, Yip HK*. An association between autosomal-dominant polycystic kidney disease and the risk of acute myocardial infarction in Asian population – results of a nationwide study. Oncotarget. 2016 Dec 27. Huang TH, Chung SY, Chua S, Chai HT, Sheu JJ, Chen YL, Chen CH, Chang HW, Tong MS, Sung PH, Sun CK, Lu HI, Yip HK*. Effect of early administration of lower dose versus high dose of fresh mitochondria on reducing monocrotaline – induced pulmonary artery hypertension in rat. Am J Transl Res. 2016 Dec 15; 8(12):5151-5168.
- Huang TH, Sun CK, Chen YL, Wang CJ, Yin TC, Lee MS, Yip HK*. Shock Wave Enhances Angiogenesis through VEGFR2 Activation and Recycling. Mol Med. 2016 Dec 6; 22.
- Lee FY, Lu HI, Chai HT, Sheu JJ, Chen YL, Huang TH, Kao GS, Chen SY, Chung SY, Sung PH, Chang HW, Lee MS, Yip HK*. Circulating microparticles enhanced rat vascular wall remodeling following endothelial denudation. Am J Transl Res. 2016 Nov 15;8(11):4511-4522.
- Chung SY, Tong MS, Sheu JJ, Lee FY, Sung PH, Chen CJ, Yang CH, Wu CJ, Yip HK*. Short-term and long-term prognostic outcomes of patients with ST-segment elevation myocardial infarction complicated by profound cardiogenic shock undergoing early extracorporeal membrane oxygenator-assisted primary percutaneous coronary intervention. Int J Cardiol. 2016 Nov15; 223:412-417.
- Chen KH, Chen CH, Wallace CG, Yuen CM, Kao GS, Chen YL, Shao PL, Chen YL, Chai HT, Lin KC, Liu CF, Chang HW, Lee MS, Yip HK*. Intravenous administration of xenogeneic adipose-derived mesenchymal stem cells (ADMSC) and ADMSC-derived exosomes markedly reduced brain infarct volume and preserved neurological function in rat after acute ischemic stroke. Oncotarget. 2016 Nov 15;7(46):74537-74556.
- Lee WC, Fang CY, Chen HC, Chen CJ, Yang CH, Hang CL, Yip HK, Fang HY, Wu CJ. Associations with 30-day survival following extracorporeal membrane oxygenation in patients with acute ST segment elevation myocardial infarction and profound cardiogenic shock. Heart Lung. 2016 Nov – Dec; 45(6):532-537.
- Wang CJ, Huang CC, Yip HK, Yang YJ. Dosage effects of extracorporeal shockwave therapy in early hip necrosis. Int J Surg. 2016 Nov; 35:179-186.
- Chua S, Lee FY, Chiang HJ, Chen KH, Lu HI, Chen YT, Yang CC, Lin KC, Chen YL, Kao GS, Chen CH, Chang HW, Yip HK*. The cardio protective effect of melatonin and exendin-4 treatment in a rat model of cardio renal syndrome. J Pineal Res. 2016 Nov; 61(4):438-456.
- Day YJ, Chen KH, Chen YL, Huang TH, Sung PH, Lee FY, Chen CH, Chai HT, Yin TC, Chiang HJ, Chung SY, Chang HW, Yip HK*. Preactivated and Disaggregated Shape-Changed Platelets Protected Against Acute Respiratory Distress Syndrome Complicated by Sepsis Through Inflammation Suppression. Shock. 2016 Nov; 46(5):575-586.
- Lee MS, Yin TC, Sung PH, Chiang JY, Sun CK, Yip HK*. Melatonin enhances survival and preserves functional integrity of stem cells: A review. J Pineal Res. 2016 Oct 13. doi: 10.1111/jpi.12372.
- Lee WC, Fang YN, Fang CY, Chen CJ, Yang CH, Yip HK, Hang CL, Wu CJ, Fang HY. Comparison of Clinical Results Following the Use of Drug-Eluting Balloons for a Bare – Metal Stent and Drug-Eluting Stent Instant Restenosis. J Interv Cordial. 2016 Oct;29(5):469-479.
- Tseng CC, Wang CC, Hsiao CC, Lu HI, Leu S, Chang HC, Huang KT, Fang WF, Chen YM, Liu SF, Yang CT, Lin MC, Yip HK*. Time courses and value of circulating micro particles in patients with operable stage non-small cell lung cancer undergoing surgical intervention. Tumors Biol. 2016 Sep; 37(9):11873-11882.
- Chang YC, Hsu SY, Yang CC, Sung PH, Chen YL, Huang TH, Kao GS, Chen SY, Chen KH, Chiang HJ, Yip HK*, Lee FY. Enhanced protection against renal ischemia-reperfusion injury with combined melatonin and exendin-4 in a rodent model. Exp Biol Med (Maywood). 2016 Aug; 241(14):1588-602.
- Lin KC, Yip HK†, Shao PL, Wu SC, Chen KH, Chen YT, Yang CC, Sun CK, Kao GS, Chen SY, Chai HT, Chang CL, Chen CH, Lee MS. Combination of adipose-derived mesenchymal stem cells (ADMSC) and ADMSC-derived exosomes for protecting kidney from acute ischemia-reperfusion injury. Int J Cordial. 2016 Aug 1; 216:173-85.
- Chen HH, Chen YT, Yang CC, Chen KH, Sung PH, Chiang HJ, Chen CH, Chua S, Chung SY, Chen YL, Huang TH, Kao GS, Chen SY, Lee MS, Yip HK*. Melatonin pretreatment enhances the therapeutic effects of exogenous mitochondria against hepatic ischemia-reperfusion injury in rats through suppression of mitochondrial permeability transition. J Pineal Res. 2016 Aug; 61(1):52-68.
- Ko SF, Yip HK, Zhen YY, Lee CC, Li JH, Lee CC, Leu S, Huang CC, Ng SH, Lin JW. Cancer Patient-Derived Circulating Micro particles Enhance Lung Metastasis in a Rat Model: Dual-Source CT, Cellular, and Molecular Studies. Mol Imaging Biol. 2016 Aug; 18(4):490-9.
- Lee WC, Wu BJ, Fang CY, Chen CJ, Yang CH, Yip HK, Hang CL, Wu CJ, Fang HY. Timing of Staged Percutaneous Coronary Intervention for a Non-Culprit Lesion in Patients With Anterior Wall ST Segment Elevation Myocardial Infarction With Multiple Vessel Disease. Int Heart J. 2016 Jul 27; 57(4):417-23.
- Yip HK*, Sung PH, Wu CJ, Yu CM. Carotid stenting and endarterectomy. Int J Cordial. 2016 Jul 1; 214:166-74.
- Chai HT, Yip HK†, Sun CK, Hsu SY, Leu S. AG490 suppresses EPO – mediated activation of JAK2-STAT but enhances blood flow recovery in rats with critical limb ischemia. J Inflame (Lond). 2016 Jun 4; 13:18.
- Lee WC, Fang HY, Chen HC, Hsueh SK, Fang CY, Chen CJ, Yip HK, Wu CJ. Comparison of a Sheath less Transradial Access With Looping Technique and Transbrachial Access for Carotid Artery Stenting. J Endovasc Ther. 2016 Jun;23(3):516-20.
- Shao PL, Liao JD, Wong TW, Wang YC, Leu S, Yip HK. Enhancement of Wound Healing by Non-Thermal N2/Ar Micro-Plasma Exposure in Mice with Fractional-CO2-Laser – Induced Wounds. PLoS One. 2016 Jun 1; 11(6):e0156699.
- Huang TH, Chung SY, Chua S, Chai HT, Sheu JJ, Chen YL, Chen CH, Chang HW, Tong MS, Sung PH, Sun CK, Lu HI, Yip HK*. Effect of early administration of lower dose versus high dose of fresh mitochondria on reducing monocrotaline-induced pulmonary artery hypertension in rat American Journal of Translational Research, 8: 5151-5168 (2016).
- Sung PH, Chiang HJ, Chen CH, Chen YL, Huang TH, Zhen YY, Chang MW, Liu CF, Chung SY, Chen YL, Chai HT, Sun CK, Yip HK*. Combined Therapy With Adipose-Derived Mesenchymal Stem Cells and Ciprofloxacin Against Acute Urogenital Organ Damage in Rat Sepsis Syndrome Induced by Intrapelvic Injection of Cecal Bacteria. Stem Cells Transl Med. 2016 Jun; 5(6):782-92.
- Lu HI, Huang TH, Sung PH, Chen YL, Chua S, Chai HY, Chung SY, Liu CF, Sun CK, Chang HW, Zhen YY, Lee FY, Yip HK*. Administration of antioxidant peptide SS-31 attenuates transverse aortic constriction-induced pulmonary arterial hypertension in mice. Acta Pharmacol Sin. 2016 May; 37(5):589-603.
- Lai CC, Lin TH, Yip HK, Liu CP, Li AH, Shyu KG, Chang SC, Mar GY. One-year cardiovascular outcomes of drug-eluting stent versus bare-metal stent implanted in diabetic patients with acute coronary syndrome. J Chin Med Assoc. 2016 May; 79(5):239-47.
- Lee WC, Fang CY, Chen HC, Hsueh SK, Chen CJ, Yang CH, Yip HK, Hang CL, Wu CJ, Fang HY. Aspiration Thrombectomy and Drug-Eluting Stent Implantation Decrease the Occurrence of Angina Pectoris One Year after Acute Myocardial Infarction. Medicine (Baltimore). 2016 Apr; 95(17):e3426.
- Tsai TH, Lu CH, Wallace CG, Chang WN, Chen SF, Huang CR, Tsai NW, Lan MY, Sung PH, Liu CF, Yip HK*. Erratum to: Erythropoietin improves long-term neurological outcome in acute ischemic stroke patients: a randomized, prospective, placebo-controlled clinical trial. Crit Care. 2016 Mar 31; 20:78.
- Ko SF, Hsu SY, Chen CH, Sung PH, Zhen MS, Chen YL, Huang TH, Chen SY, Kao GS, Chen HH, Chang CL, Sun CK, Chang HW, Yip HK*. Human lung cancer-derived micro particles enhanced angiogenesis and growth of hepatoma cells in rodent lung parenchyma. Am J Transl Res. 2016 Mar 15; 8(3):1302-18.
- Lu HI, Chung SY, Chen YL, Huang TH, Zhen YY, Liu CF, Chang MW, Chen YL, Sheu JJ, Chua S, Yip HK*, Lee FY. Exendin-4 therapy still offered an additional benefit on reducing transverse aortic constriction-induced cardiac hypertrophy-caused myocardial damage in DPP-4 deficient rats. Am J Transl Res. 2016 Feb 15; 8(2):778-98.
- Yip HK†, Yuen CM, Chen KH, Chai HT, Chung SY, Tong MS, Chen SY, Kao GS, Chen CH, Chen YL, Huang TH, Sun CK, Lee MS. Tissue plasminogen activator deficiency preserves neurological function and protects against murine acute ischemic stroke. Int J Cardiol. 2016 Feb 15; 205:133-41.
- Chen HC, Lee WC, Chen YL, Fang HY, Chen CJ, Yang CH, Hang CL, Fang CY, Yip HK *, Wu CJ. The impacts of prolonged emergency department length of stay on clinical outcomes of patients with ST-segment elevation myocardial infarction after reperfusion. Intern Emerge Med. 2016 Feb; 11(1):107-14.
- Sung PH, Wu CJ, Yip HK*. Is Extracorporeal Membrane Oxygenator a New Weapon to Improve Prognosis in Patients With Profound Cardiogenic Shock Undergoing Primary Percutaneous Coronary Intervention? Circ J. 2016; 80(3):572-8.
- Leu S, Day YJ, Sun CK, Yip HK*. tPA-MMP-9 Axis Plays a Pivotal Role in Mobilization of Endothelial Progenitor Cells from Bone Marrow to Circulation and Ischemic Region for Angiogenesis. Stem Cells Int. 2016; 2016:5417565.
- Chen YL, Chen KH, Yin TC, Huang TH, Yuen CM, Chung SY, Sung PH, Tong MS, Chen CH, Chang HW, Lin KC, Ko SF, Yip HK*. Extracorporeal shock wave therapy effectively prevented diabetic neuropathy. Am J Transl Res. 2015 Dec 15; 7(12):2543-60.
- Chen YL, Tsai TH, Wallace CG, Chen YL, Huang TH, Sung PH, Yuen CM, Sun CK, Lin KC, Chai HT, Sheu JJ, Lee FY, Yip HK*. Intra-carotid arterial administration of autologous peripheral blood-derived endothelial progenitor cells improves acute ischemic stroke neurological outcomes in rats. Int J Cardiol. 2015 Dec15; 201:668-83.
- Wang CJ, Cheng JH, Huang CC, Yip HK, Russo S. Extracorporeal shockwave therapy for avascular necrosis of femoral head. Int J Surg. 2015 Dec; 24(PtB):184-7.
- Chen YL, Chung SY, Chai HT, Chen CH, Liu CF, Chen YL, Huang TH, Zhen YY, Sung PH, Sun CK, Chua S, Lu HI, Lee FY, Sheu JJ, Yip HK*. Early Administration of Carvedilol Protected against Doxorubicin-Induced Cardiomyopathy. J Pharmacol Exp Ther. 2015 Dec; 355(3):516-27.
- Lee WC, Chen HC, Fang HY, Hsueh SK, Chen CJ, Yang CH, Yip HK, Wu CJ, Fang CY, Hang CL. Comparison of different strategies for acute ST-segment elevation myocardial infarction with high thrombus burden in clinical practice: Symptom-free outcome at one year. Heart Lung. 2015 Nov-Dec; 44(6):487-93.
- Yip HK†, Yang CC, Chen KH, Huang TH, Chen YL, Zhen YY, Sung PH, Chiang HJ, Sheu JJ, Chang CL, Chen CH, Chang HW, Chen YT. Combined melatonin and exendin-4 therapy preserves renal ultrastructural integrity after ischemia-reperfusion injury in the male rat. J Pineal Res. 2015 Nov; 59(4):434-47.
- Lee FY, Chen YL, Sung PH, Ma MC, Pei SN, Wu CJ, Yang CH, Fu M, Ko SF, Leu S, Yip HK*. Intracoronary Transfusion of Circulation-Derived CD34+ Cells Improves Left Ventricular Function in Patients With End-Stage Diffuse Coronary Artery Disease Unsuitable for Coronary Intervention. Crit Care Med. 2015 Oct;43(10):2117-32.
- Lee WC, Chen SM, Liu CF, Chen CJ, Chung WJ, Hsueh SK, Tsai TH, Fang HY, Yip HK, Hang CL. Early Administration of Intracoronary Nitroprusside Compared with Thrombus Aspiration in Myocardial Perfusion for Acute Myocardial Infarction: A 3-Year Clinical Follow-Up Study. Acta Cardiol Sin. 2015 Sep; 31(5):373-80.
- Chang CL, Sung PH, Sun CK, Chen CH, Chiang HJ, Huang TH, Chen YL, Zhen YY, Chai HT, Chung SY, Tong MS, Chang HW, Chen HH, Yip HK*. Protective effect of melatonin-supported adipose-derived mesenchymal stem cells against small bowel ischemia-reperfusion injury in rat. J Pineal Res. 2015 Sep; 59(2):206-20.
- Sheu JJ, Lee FY, Yuen CM, Chen YL, Huang TH, Chua S, Chen YL, Chen CH, Chai HT, Sung PH, Chang HW, Sun CK, Yip HK*. Combined therapy with shock wave and autologous bone marrow-derived mesenchymal stem cells alleviates left ventricular dysfunction and remodeling through inhibiting inflammatory stimuli, oxidative stress & enhancing angiogenesis in a swine myocardial infarction model. Int J Cardiol. 2015 Aug 15; 193:69-83.
- Yuen CM, Chung SY, Tsai TH, Sung PH, Huang TH, Chen YL, Chen YL, Chai HT, Zhen YY, Chang MW, Wang CJ, Chang HW, Sun CK, Yip HK*. Extracorporeal shock wave effectively attenuates brain infarct volume and improves neurological function in rat after acute ischemic stroke. Am J Transl Res. 2015 Jun 15;7(6):976-94.
- Huang TH, Chen YT, Sung PH, Chiang HJ, Chen YL, Chai HT, Chung SY, Tsai TH, Yang CC, Chen CH, Chen YL, Chang HW, Sun CK, Yip HK*. Peripheral blood-derived endothelial progenitor cell therapy prevented deterioration of chronic kidney disease in rats. Am J Transl Res. 2015 May 15; 7(5):804-24.
- Chen YL, Sun CK, Tsai TH, Chang LT, Leu S, Zhen YY, Sheu JJ, Chua S, Yeh KH, Lu HI, Chang HW, Lee FY, Yip HK*. Adipose-derived mesenchymal stem cells embedded in platelet-rich fibrin scaffolds promote angiogenesis, preserve heart function, and reduce left ventricular remodeling in rat acute myocardial infarction. Am J Transl Res. 2015 May 15; 7(5):781-803.
- Tsai TH, Sun CK, Su CH, Sung PH, Chua S, Zhen YY, Leu S, Chang HW, Yang JL, Yip HK*. Sitagliptin attenuated brain damage and cognitive impairment in mice with chronic cerebral hypo-perfusion through suppressing oxidative stress and inflammatory reaction. J Hypertens. 2015 May; 33(5):1001-13.
- Sun CK, Lee FY, Kao YH, Chiang HJ, Sung PH, Tsai TH, Lin YC, Leu S, Wu YC, Lu HI, Chen YL, Chung SY, Su HL, Yip HK*. Systemic combined melatonin-mitochondria treatment improves acute respiratory distress syndrome in the rat. J Pineal Res. 2015 Mar; 58(2):137-50.
- Sheu JJ, Chang MW, Wallace CG, Chiang HJ, Sung PH, Tsai TH, Chung SY, Chen YL, Chua S, Chang HW, Sun CK, Lee FY, Yip HK*. Exendin-4 protected against critical limb ischemia in obese mice. Am J Transl Res. 2015 Mar 15; 7(3):445-59.
- Tsai TH, Lu CH, Wallace CG, Chang WN, Chen SF, Huang CR, Tsai NW, Lan MY, Sung PH, Liu CF, Yip HK*. Erythropoietin improves long-term neurological outcome in acute ischemic stroke patients: a randomized, prospective, placebo-controlled clinical trial. Crit Care. 2015 Feb 25; 19:49.
- Sun CK, Leu S, Hsu SY, Zhen YY, Chang LT, Tsai CY, Chen YL, Chen YT, Tsai TH, Lee FY, Sheu JJ, Chang HW, Yip HK*. Mixed serum-deprived and normal adipose-derived mesenchymal stem cells against acute lung ischemia-reperfusion injury in rats. Am J Transl Res. 2015 Feb 15; 7(2):209-31.
- Sheu JJ, Lee FY, Wallace CG, Tsai TH, Leu S, Chen YL, Chai HT, Lu HI, Sun CK, Yip HK*. Administered circulating microparticles derived from lung cancer patients markedly improved angiogenesis, blood flow and ischemic recovery in rat critical limb ischemia. J Transl Med. 2015 Feb 15; 13:59.
- Chang MW, Chen CH, Chen YC, Wu YC, Zhen YY, Leu S, Tsai TH, Ko SF, Sung PH, Yang CC, Chiang HJ, Chang HW, Chen YT, Yip HK*. Sitagliptin protects rat kidneys from acute ischemia-reperfusion injury via upregulation of GLP-1 and GLP-1 receptors. Acta Pharmacol Sin. 2015 Jan; 36(1):119-30.
- Chen YL, Chen CH, Wallace CG, Wang HT, Yang CC, Yip HK*. Levels of circulating micro particles in patients with chronic cardio renal disease. J Atheroscler Thromb. 2015; 22(3):247-56.
- Ko SF, Yip HK, Zhen YY, Lee CC, Lee CC, Huang CC, Ng SH, Lin JW. Adipose-Derived Mesenchymal Stem Cell Exosomes Suppress Hepatocellular Carcinoma Growth in a Rat Model: Apparent Diffusion Coefficient, Natural Killer T-Cell Responses, and Histopathological Features. Stem Cells Int. 2015; 2015:853506.
- Chua S, Lee FY, Tsai TH, Sheu JJ, Leu S, Sun CK, Chen YL, Chang HW, Chai HT, Liu CF, Lu HI, Yip HK*. Inhibition of dipeptidyl peptidase-IV enzyme activity protects against myocardial ischemia-reperfusion injury in rats. J Transl Med. 2014 Dec 13; 12:357.
- Chen YT, Yang CC, Sun CK, Chiang HJ, Chen YL, Sung PH, Zhen YY, Huang TH, Chang CL, Chen HH, Chang HW, Yip HK*. Extracorporeal shock wave therapy ameliorates cyclophosphamide-induced rat acute interstitial cystitis though inhibiting inflammation and oxidative stress-in vitro and in vivo experiment studies. Am J Transl Res. 2014 Nov 22; 6(6):631-48.
- Lai CC, Yip HK, Lin TH, Wu CJ, Lai WT, Liu CP, Chang SC, Mar GY. Drug-Eluting Stents versus Bare-Metal Stents in Taiwanese Patients with Acute Coronary Syndrome: An Outcome Report of a Multicenter Registry. Acta Cordial Sin. 2014 Nov; 30(6):553-64.
- Lee WC, Tsai TH, Chen YL, Yang CH, Chen SM, Chen CJ, Lin CJ, Cheng CI, Hang CL, Wu CJ, Yip HK*. Safety and feasibility of coronary stenting in unprotected left main coronary artery disease in the real world clinical practice–a single center experience. PLoS One. 2014 Oct 20; 9(10):e109281.
- Chen HH, Chang CL, Lin KC, Sung PH, Chai HT, Zhen YY, Chen YC, Wu YC, Leu S, Tsai TH, Chen CH, Chang HW, Yip HK*. Melatonin augments apoptotic adipose-derived mesenchymal stem cell treatment against sepsis-induced acute lung injury. Am J Transl Res. 2014 Oct 11; 6(5):439-58.
- Fang HY, Lu SY, Lee WC, Lin YS, Cheng CI, Chen CJ, Yang CH, Yip HK, Hang CL, Fang CY, Wu CJ. The predictors of successful percutaneous coronary intervention in ostial left anterior descending artery chronic total occlusion. Catheter Cardiovasc Interv. 2014 Oct 1; 84(4):E30-7.
- Chen YT, Chiang HJ, Chen CH, Sung PH, Lee FY, Tsai TH, Chang CL, Chen HH, Sun CK, Leu S, Chang HW, Yang CC, Yip HK*. Melatonin treatment further improves adipose-derived mesenchymal stem cell therapy for acute interstitial cystitis in rat. J Pineal Res. 2014 Oct; 57(3):248-61.
- Ho YC, Tsai TH, Sung PH, Chen YL, Chung SY, Yang CH, Chen SM, Chen CJ, Fang HY, Wu CJ, Yip HK*. Minimizing door-to-balloon time is not the most critical factor in improving clinical outcome of ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention. Crit Care Med. 2014 Aug; 42(8):1788-96.
- Chen HH, Lin KC, Wallace CG, Chen YT, Yang CC, Leu S, Chen YC, Sun CK, Tsai TH, Chen YL, Chung SY, Chang CL, Yip HK*. Additional benefit of combined therapy with melatonin and apoptotic adipose-derived mesenchymal stem cell against sepsis-induced kidney injury. J Pineal Res. 2014 Aug; 57(1):16-32.
- Sun CK, Zhen YY, Leu S, Tsai TH, Chang LT, Sheu JJ, Chen YL, Chua S, Chai HT, Lu HI, Chang HW, Lee FY, Yip HK*. Direct implantation versus platelet-rich fibrin-embedded adipose-derived mesenchymal stem cells in treating rat acute myocardial infarction. Int J Cardiol. 2014 May 15; 173(3):410-23.
- Sheu JJ, Lin PY, Sung PH, Chen YC, Leu S, Chen YL, Tsai TH, Chai HT, Chua S, Chang HW, Chung SY, Chen CH, Ko SF, Yip HK*. Levels and values of lipoprotein-associated phospholipase A2, galectin-3, RhoA/ROCK, and endothelial progenitor cells in critical limb ischemia: pharmaco-therapeutic role of cilostazol and clopidogrel combination therapy. J Transl Med. 2014 Apr 17; 12:101.
- Ko SF, Huang CC, Lin JW, Lu HI, Kung CT, Ng SH, Wan YL, Yip HK*. Imaging features and outcomes in 10 cases of idiopathic azygos vein aneurysm. Ann Thorac Surg. 2014 Mar; 97(3):873-8.
- Abdou SM, Yip HK, Wu CJ. Transradial retrograde approach rescuing iatrogenic long spiral dissection during chronic total occlusion intervention. Catheter Cardiovasc Interv. 2014 Feb 15; 83(3):E159-64.
- Lin YS, Fang HY, Hussein H, Fang CY, Chen YL, Hsueh SK, Cheng CI, Yang CH, Chen CJ, Hang CL, Yip HK, Wu CJ. Predictors of contrast-induced nephropathy in chronic total occlusion percutaneous coronary intervention. EuroIntervention. 2014 Feb;9(10):1173-80.
- Ko SF, Yip HK, Leu S, Lee CC, Sheu JJ, Lee CC, Ng SH, Huang CC, Chen MC, Sun CK. Therapeutic potential of tacrolimus on acute myocardial infarction in mini pigs: analysis with serial cardiac magnetic resonance and changes at histological and protein levels. Biomed Res Int. 2014; 2014:524078.
- Wang CC, Tseng CC, Hsiao CC, Chang HC, Chang LT, Fang WF, Leu S, Wang YH, Tsai TH, Yang CT, Chen CH, Yip HK, Ho CK, Lin MC. Circulating endothelial-derived activated micro particle: a useful biomarker for predicting one-year mortality in patients with advanced non-small cell lung cancer. Biomed Res Int. 2014; 2014:173401.
- Cheng CI, Lin YC, Tsai TH, Lin HS, Liou CW, Chang WN, Lu CH, Yuen CM, Yip HK*.The prognostic values of leukocyte Rho kinase activity in acute ischemic stroke. Biomed Res Int. 2014; 2014:214587.
- Fan CQ, Leu S, Sheu JJ, Zhen YY, Tsai TH, Chen YL, Chung SY, Chai HT, Sun CK, Yang JL, Chang HW, Ko SF, Yip HK*. Prompt bone marrow-derived mesenchymal stem cell therapy enables early porcine heart function recovery from acute myocardial infarction. Int Heart J. 2014; 55(4):362-71.
- Leu S, Lu HI, Sun CK, Sheu JJ, Chen YL, Tsai TH, Yeh KH, Chai HT, Chua S, Tsai CY, Chang HW, Lee FY, Yip HK*. Retention of endothelial progenitor cells in bone marrow in a murine model of endogenous tissue plasminogen activator (tPA) deficiency in response to critical limb ischemia. Int J Cardiol. 2014 Jan1; 170(3):394-405.
- Chen YL, Tsai TH, Sung PH, Wang HT, Lin HS, Chang WN, Lu CH, Chen SF, Huang CR, Tsai NW, Wu CJ, Yip HK*. Levels of circulating neopterin in patients with severe carotid artery stenosis undergoing carotid stenting. J Atheroscler Thromb. 2014; 21(2):129-39.
- Sun CK, Zhen YY, Lu HI, Sung PH, Chang LT, Tsai TH, Sheu JJ, Chen YL, Chua S, Chang HW, Chen YL, Lee FY, Yip HK*. Reducing TRPC1 Expression through Liposome-Mediated siRNA Delivery Markedly Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension in a Murine Model. Stem Cells Int. 2014; 2014:316214.
黃田宏博士後研究員
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陳怡伶博士後研究員
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翁郁婷研究助理
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石憶琳研究助理
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劉玉雯研究助理
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EDUCATION: 1984-1991 Department of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan PROFESSIONAL EXPERIENCE:
RESEARCH INTERESTS: |