成員介紹

Selected Recent Publications (Pubmed Search)

(† Contributed equally to the article; * Correspondence author of the article)

Poon YY, Tsai CY, Huang YH, Wu JCC, Chan SHH* Chan JYH*. Disproportional cardiovascular depressive effects of isoflurane: Serendipitous findings from a comprehensive re-visit in mice. Lab Animal, 50: 26-31 (2021).

Chan SHH*. Reinstatement of respiratory sinus arrhythmia as a therapeutic target of cardiac pacing for the management of heart failure. Journal of Physiology, 598: 433-434 (2020).

Chan JYH and Chan SHH*. Differential impacts of brain stem oxidative stress and nitrosative stress on sympathetic vasomotor tone. Pharmacology & Therapeutics, 201: 120-136 2019).

Mukda S, Tsai CY, Leu S, Yang JL and Chan SHH*. Pinin protects astrocytes from cell death after acute ischemic stroke via maintenance of mitochondrial anti-apoptotic and bioenergetics functions. Journal of Biomedical Science, 26: e43 (2019).

Tsai CY, Poon YY, Chan JYH*, Chan SHH*. Baroreflex functionality in the eye of diffusion tensor imaging. The Journal of Physiology, 597: 41-55 (2019).

Tsai CY†, Poon YY†, Huang YH, Chan SHH*. Activation of spinal nociceptin receptors induces cardiovascular depression and antinociception in an independent manner in mice. Journal of Pain Research, 11: 2699-2708 (2018).

Tsai CY, Poon YY, Chen CH, Chan SHH*. Anomalous baroreflex functionality inherent in floxed and Cre-Lox mice: an overlooked physiological phenotype. American Journal of Physiology-Heart and Circulatory Physiology, 313: H700-H707 (2017).

Chan SHH, Chan JYH*. Mitochondria and reactive oxygen species contribute to neurogenic hypertension. Physiology (Bethesda), 32: 308-321 (2017).

Tsai CY, Su CH, Chan JYH, Chan SHH*. Nitrosative stress-induced disruption of baroreflex neural circuits in a rat model of hepatic encephalopathy: a DTI study. Scientific Reports, 7: 40111 (2017).

Chan SHH, Chan JYH*. Phosphodiesterase 2 as a Therapeutic Target for Heart Failure: Is Upregulation an Option? Circulation Research, 120: 13-16 (2017).

Tsai CY, Li FCH, Wu CHY, Chang AYW, Chan SHH*. Sumoylation of IκB attenuates NF-κB-induced nitrosative stress at rostral ventrolateral medulla and cardiovascular depression in experimental brain death. Journal of Biomedical Science, 23: 65 (2016).

Poon YY†, Tsai CY†, Cheng CD, Chang AYW, Chan SHH*. Endogenous nitric oxide derived from NOS I or II in thoracic spinal cord exerts opposing tonic modulation on sympathetic vasomotor tone via disparate mechanisms in anesthetized rats.American Journal of Physiology-Heart and Circulatory Physiology, 311: H555-H562 (2016).

Su CH†, Tsai CY†, Chang AYW, Chan JYH, Chan SHH*. MRI/DTI of the brain stem reveals reversible and irreversible disruption of the baroreflex neural circuits: clinical implications. Theranostics, 6: 837-848 (2016).

Chan JYH, Chan SHH*. Activation of endogenous antioxidants as a common therapeutic strategy against cancer, neurodegeneration and cardiovascular diseases: A lesson learnt from DJ-1. Pharmacology & Therapeutics, 156: 68-74 (2015).

Chan SHH, Chan JYH*. Brain stem NOS and ROS in neural mechanisms of hypertension. Antioxidants and Redox Signaling, 20: 146-163 (2014).

Tsai CY†, Chang AYW†, Chan JYH, Chan SHH*. Activation of PI3K/Akt signaling in rostral ventrolateral medulla impairs brain stem cardiovascular regulation that underpins circulatory depression during mevinphos intoxication. Biochemical Pharmacology, 88: 75-85 (2014).

Tsai CY, Chua S, Leu S, Chang AYW, Chan JYH, Chan SHH*. VEGF tonically sustains myocardial performance via fetal liver kinase-1 in the heart. International Journal of Cardiology, 177: 727-730 (2014).

 

EDUCATION:
1968           B.Sc. cum laude in Biology, Chinese University of Hong Kong, Hong Kong
1971           Ph.D. in Physiology, Indiana University, Bloomington, IN, USA
1971-72     Postdoctoral Fellow in Neurology, Mount Sinai School of Medicine, New York, NY, USA

PROFESSIONAL EXPERIENCE:
2013-          Director, Institute for Translational Research in Biomedicine, Chang Gung Memorial Hospital, Kaohsiung, Taiwan
2010-          Chair Professor, Institute of Neurobiology, Xi’an Jiaotong University, Xi’an, China
2010-          Honorary Professor, Institute of Brain Science, Fudan University, Shanghai, China
2009-13      Director, Center for Translational Research in Biomedical Sciences, Chang Gung Memorial Hospital, Kaohsiung, Taiwan
2009-          Distinguished Chair Professor, Chang Gung Memorial Hospital, Taiwan
2005-09      Adjunct Professor of Pharmacology, National Cheng Kung University, Tainan, Taiwan
2003-09      Sun Yat-sen Research Chair Professor, National Sun Yat-sen University, Kaohsiung, Taiwan
2002-04      Vice-President for Academic Affairs, National Sun Yat-sen University, Kaohsiung, Taiwan
2000-          Honorary Professor, Department of Physiology, Faculty of Medicine, University of Hong Kong, Hong Kong
2000-          Lifetime National Chair Professor of Neuroscience, Ministry of Education, Taiwan
1998-09      Professor, Department of Biological Science, National Sun Yat-sen University, Kaohsiung, Taiwan
1998-09      Director, Center for Neuroscience, National Sun Yat-sen University, Kaohsiung, Taiwan
1997-00      National Chair Professor of Neuroscience, Ministry of Education, Taiwan
1995-98      Director, Center for Neuroscience, National Yang-Ming University, Taipei, Taiwan
1994-98      Adjunct Professor, Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan
1993-97      Adjunct Professor, Institute of Clinical Medicine, Chang Gung Medical College, Taoyuan, Taiwan
1987-94      Director, Institute of Pharmacology, National Yang-Ming Medical College, Taipei, Taiwan
1986-98      Professor, Institute of Pharmacology, National Yang-Ming Medical College, Taipei, Taiwan
1985-86      Visiting Professor, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
1982-85      Professor, Department of Physiology, Faculty of Medicine, National University of Singapore, Kent Ridge, Singapore
1978-82      Professor (80-82) and Associate Professor (78-80), Department of Physiology, Indiana University, Terre Haute, IN, USA
1977-80      Associate Professor, Department of Life Science, Indiana State University, Terre Haute, Indiana, USA
1973-76      Assistant Professor, Department of Physiology, Faculty of Medicine, University of Hong Kong, Hong Kong
1972-73      Assistant Professor, Department of Physiology, Faculty of Medicine, University of Singapore, Sepoy Lines, Singapore

PROFESSIONAL AWARDS:
2009-          Distinguished Chair Professor, Chang Gung Memorial Hospital, Taiwan
2003-09      Sun Yat-sen Research Chair Professor, National Sun Yat-sen University, Taiwan
2002            Outstanding Commissioned Researcher, National Science Council, Taiwan
2000-          Lifetime National Chair Professor of Neuroscience, Ministry of Education, Taiwan
1997-00      National Chair Professor (Neuroscience), Ministry of Education, Taiwan
1996-02      Commissioned Researcher Award, National Science Council, Taiwan
1995            Wang Ming-Ling Award for Outstanding Contribution to Medicine,
Wang Ming-Ling Memorial Foundation, Taiwan
1995            Shih-Chun Wang Outstanding Investigator Lectureship in Neuroscience,
Professor Shih-Chun Wang Memorial Scholarship Fund, USA
1987            Tjing-Ling Medical Foundation Professorship, Taiwan
1986-96      Outstanding Researcher Award, National Science Council, Taiwan

PROFESSIONAL HONORS:
2015-          Chairman, Medical Research and Development Board, Chang Gung Medical Foundation, Taiwan
2012-15      Vice-Chairman, Medical Research and Development Board, Chang Gung Medical Foundation, Taiwan
2011-16      President, Asia Pacific Federation of Pharmacologists, Sydney, Australia
2011-          Member, Scientific Advisory Board, Neuroscience Program in Academia Sinica, Taiwan
2010-          Member, Asian-Pacific Society for Neurochemistry Council, Singapore
2010-16      Chairman, Departmental Advisory Committee, Department of Health Technology & Informatics,Hong Kong Polytechnic University, Hong Kong
2008-10      President, Neuroscience Society of Taiwan, Taiwan
2007-11      President-elect, Southeast Asia-Western Pacific Regional Federation of Pharmacologists, Sydney, Australia
2004-08      President, Pharmacological Society in Taiwan, Taiwan
2003-          Member, IBRO Advisory Science Program Committee, Paris, France
2002-          Member, Scientific Review Board, National Health Research Institutes, Taiwan
2002-06      Member, Asia-Pacific Regional Committee, International Brain Research Organization (IBRO), Paris, France
1999-07      Secretary General, Southeast Asia-Western Pacific Regional Federation of Pharmacologists, Sydney, Australia
1997-00      Inaugural Executive Committee Member, International Society for Autonomic Neuroscience Research, London, UK
1995-97      Advisory Member, Japanese Neurocardiology Study Group, Japan
1995-02      Commissioner, Commission on Autonomic Nervous System, International Union of Physiological Sciences, Washington, D.C., USA
1994-96      Coordinator, Neuroscience and Pharmacology Program, Taiwan-France Scientific Collaboration, National Science Council, Taiwan
1992-99      Honorary Consultant, Veterans General Hospital-Taipei, Taiwan
1989-          Advisory Consultant, Hong Kong Research Grants Council, Hong Kong

RESEARCH INTERESTS:
Neuroscience, Experimental Medicine, Neuropharmacology, Neurophysiology

SCHOLARLY ACTIVITIES:

1. Chief Editor (2005-)
　Translational Research in Biomedicine
　(Monograph series published by Karger AB, Switzerland)

　Volume 1: Human Cancer Viruses (J. Nicholas, K.-T. Jeang, T.-C. Wu, volume editors), 2008
　Volume 2: Cell Migration: Signaling and Mechanisms (F. Entschladen, K.S. Zänker, volume editors), 2010
　Volume 3: Translational Medicine – What, Why and How. An International Perspective
　(B. Alving, K. Dai, S.H.H. Chan, volume editors), 2013
　Volume 4: Mistletoe. From Mythology to Evidence-Based Medicine (K.S. Zänker, S.V. Kaveri, volume editors), 2015
　Volume 5: From Auto- to Allo-transplantation (Fu-Chan Wei, Hui-Yun Cheng, Cheng-Hung Lin, volume editors), 2016

2. Editor-in-Chief (1998-2004), Associate Editor (1992-97)
　Journal of Biomedical Science

3. Editorial Board
Autonomic Neuroscience, Basic and Clinical, 2000-2014
Biochemical Pharmacology, 2013-
Biological Signals and Receptors, 1992-2001
Biomedicine Hub (Senior Editor), 2015-
Chinese Journal of Physiology, 1989-92

4. External Grant Reviewer
　Research Grants Council, Hong Kong
　National Health & Medical Research Council of Australia
　Qatar Foundation
　The Wellcome Trust, UK
　Israel Science Foundation

5. Ad hoc Editorial Consultant
American Journal of Physiology
Analytica Chimica Acta
Antioxidants and Redox Signaling
Brain Research
British Journal of Pharmacology
Circulation
Circulation Research
Free Radical Biology & Medicine
Journal of the Autonomic Nervous System
Journal of Biochemical and Biophysical Methods
Journal of Chemical Neuroanatomy
Journal of Neurochemistry
Journal of Neurophysiology
Journal of Neuroscience Methods
Journal of Pharmacological Sciences
Journal of Physiology (London)
Life Sciences
Microscopy Research and Technique
Nature Protocols
Neurochemistry International
Neuropharmacology
Neuroscience
Neuroscience Letters
Pharmacology, Behavior and Biochemistry
PLoS ONE
Progress in Neurobiology
Scientific Reports

6. Council Member
Chinese Pharmacological Society, 1992-
Neuroscience Society, Taiwan, 1992-
Chinese Physiological Society, 1993-95
International Society for Autonomic Neuroscience Research, 1997-2002
Secretary General, Southeast Asian-Western Pacific Regional Federation of Pharmacologists, 1999-2007
President, Pharmacological Society in Taiwan, 2004-2008
President-elect, Southeast Asian-Western Pacific Regional Federation of Pharmacologists, 2007-11
President, Taiwan Neuroscience Society, 2008-2010
Asian-Pacific Society for Neurochemistry, 2010-
President, Asia Pacific Federation of Pharmacologists, 2011-16