成員介紹

Selected Recent Publication (Pubmed Search)
(^† Contributed equally to the article; * Correspondence author of the article)

1^st author publications (2015-2020)

1. Tain YL*, Huang LT, Lee CT, Chan JY, Hsu CN. Maternal citrulline supplementation prevents prenatal ng-nitro-l-arginine-methyl ester (L-NAME)-induced programmed hypertension in rats. Biol Reprod. 92(1), 7, 2015 (SCI, IF=3.322; Reproductive Biology 7/29= 24.1%)
2. Tain YL, Wu KL, Lee WC, Leu S, Chan JY. Maternal fructose intake-induced renal programming in adult male offspring. J Nutritional Biochemistry, 26: 642-650, 2015 (IF=4.873, Nutrition & Dietetics 15/89= 16.9%)
3. Tain YL*, Huang LT, Chan JY, Lee CT. Transcriptome Analysis in Rat Kidneys: Importance of Genes Involved in Programmed Hypertension. Int. J. Mol. Sci 16(3):4744-58, 2015 (SCI; IF=4.556; Biochemistry & Molecular Biology 74/297= 24.9%)
4. Tain YL*, Hsu CN, Chan JY, Huang LT. Renal Transcriptome Analysis of Programmed Hypertension Induced by Maternal Nutritional Insults. Int. J. Mol. Sci. 16(8): 17826-17837, 2015 (SCI; IF=4.556; Biochemistry & Molecular Biology 74/297= 24.9%)
5. Tain YL, Lee WC, Leu S, Wu KL, Chan JY. High salt exacerbates programmed hypertension in maternal fructose-fed male offspring. Nutr Metab Cardiovas Dis. 25(12): 1146–1151, 2015 (IF=3.318, Nutrition & Dietetics 27/81= 33.3%)
6. Tain YL. Targeting redox balance to deprogramme obesity: are we starting early enough? J Physiol. 593(21):4689-90, 2015 (IF=4.547, Physiology 11/81= 13.6%)
7. Tain YL, Sheen JM, Yu HR, Chen CC, Tiao MM, Hsu CN, Lin YJ, Kuo KC, Huang LT. Maternal melatonin therapy rescues prenatal dexamethasone and postnatal high-fat diet induced programmed hypertension in male rat offspring. Front.Physiol.6:377, 2015 (IF=3.367, Physiology 20/81= 24.7%)
8. Tain YL, Joles JA. Reprogramming: A preventive strategy in hypertension focusing on the kidney. Int J Mol Sci. 17(1):23, 2016 (SCI; IF=4.556; Biochemistry & Molecular Biology 74/297= 24.9%)
9. Tain YL, Hsu CN, Chan J. PPARs link Early Life Nutritional Insults to Later Programmed Hypertension and Metabolic Syndrome. Int J Mol Sci. 17(1):20, 2016 (SCI; IF=4.556; Biochemistry & Molecular Biology 74/297= 24.9%)
10. Tain YL, Luh H, Lin CY, Hsu CN. Incidence and risks of congenital anomalies of kidney and urinary tract in newborns: a population-based case-control study in Taiwan. Medicine (Baltimore). 95(5):e2659, 2016. (SCI; IF=2.028; Medicine, General & Internal 56/154= 36.4%)
11. Tain YL*, Hsu CN, Lee CT, Lin YJ, Tsai CC. N-acetylcysteine prevents programmed hypertension in male offspring born to suramin-treated mothers. Biol Reprod. 95(1):8, 1–8, 2016 (SCI, IF=3.322; Reproductive Biology 7/29= 24.1%)
12. Tain YL, Lee CT, Chan JY, Hsu CN*. Maternal melatonin or N-acetylcysteine therapy regulates hydrogen sulfide-generating pathway and renal transcriptome to prevent prenatal NG-Nitro-L-arginine-methyl ester (L-NAME)-induced fetal programming of hypertension in adult male offspring. Am J Obstet Gynecol. 2016, 215(5): 636.e1-e72 (SCI, IF=6.502; Obstetrics & Gynecology 2/82= 2.4%)
13. Tain YL*, Wu MS, Lin YJ. Sex differences in renal transcriptome and programmed hypertension in offspring exposed to prenatal dexamethasone. Steroids 115: 40-46, 2016 (SCI; IF=2.523; Biochemistry & Molecular Biology 175/292= 59.9%)
14. Tain YL, Lee WC, Wu KL, Leu S, Chan JY. Targeting arachidonic acid pathway to prevent programmed hypertension in maternal fructose-fed male adult rat offspring. J Nutr Biochem 38:86-92, 2016 (IF=4.873, Nutrition & Dietetics 15/89= 16.9%)
15. Tain YL, Chan JY, Hsu CN. Maternal fructose intake affects transcriptome changes and programmed hypertension in offspring in later life. Nutrients 8, 757, 2016 (IF=4.546, Nutrition & Dietetics 17/89= 19.1%).
16. Tain YL, Hsu CN. Targeting on asymmetric dimethylarginine related nitric oxide-reactive oxygen species imbalance to reprogram the development of hypertension. Int J Mol Sci. 17, 2020, 2016 (SCI; IF=4.556; Biochemistry & Molecular Biology 74/297= 24.9%)
17. Tain YL, Hsu CN. Developmental Origins of Chronic Kidney Disease: Should We Focus on Early Life? Int J Mol Sci. 18, 381, 2017 (SCI; IF=4.556; Biochemistry & Molecular Biology 74/297= 24.9%)
18. Tain YL, Huang LT, Hsu CN. Developmental Programming of Adult Disease: Reprogramming by Melatonin? Int J Mol Sci. 18, 426, 2017 (SCI; IF=4.556; Biochemistry & Molecular Biology 74/297= 24.9%)
19. Tain YL, Hsu CN. Toxic Dimethylarginines: Asymmetric Dimethylarginine (ADMA) and Symmetric Dimethylarginine (SDMA). Toxins (Basel). 2017 Mar 6;9(3). pii: E92 (SCI; IF=3.273; Toxicology 25/94= 26.6%)
20. Tain YL, Lin YJ, Sheen JM, Yu HR, Tiao MM, Chen CC, Tsai CC, Huang LT, Hsu CN. High Fat Diets Sex-Specifically Affect the Renal Transcriptome and Program Obesity, Kidney Injury, and Hypertension in the Offspring. Nutrients. 9(4): 357, 2017. (IF=4.546, Nutrition & Dietetics 17/89= 19.1%)
21. Tain YL, Hsu CN. Interplay between Oxidative Stress and Nutrient Sensing Signaling in the Developmental Origins of Cardiovascular Disease. Int. J. Mol. Sci. 18, 481, 2017. (SCI; IF=4.556; Biochemistry & Molecular Biology 74/297= 24.9%)
22. Tain YL, Lin YJ, Sheen JM, Lin IC, Yu HR, Huang LT, Hsu CN. Resveratrol prevents the combined maternal plus postweaning high-fat-diets-induced hypertension in male offspring. J Nutr Biochem. 2017 Jun 24;48:120-127. (IF=4.873, Nutrition & Dietetics 15/89= 16.9%)
23. Tain YL, Lin YJ, Chan JY, Lee CT, Hsu CN. Maternal melatonin or agomelatine therapy prevents programmed hypertension in male offspring of mother exposed to continuous light. Biol Reprod. 97(4): 636-643, 2017 (SCI, IF=3.322; Reproductive Biology 7/29= 24.1%)
24. Tain YL, Hsu CN, Lu PC. Early short-term treatment with exogenous hydrogen sulfide postpones the transition from prehypertension to hypertension in spontaneously hypertensive rat. Clin Exp Hypertens. 40(1): 58-64, 2018 (SCI; IF=1.605; Peripheral Vascular Disease 52/65= 80%)
25. Tain YL, Chan SHH, Chan JYH. Biochemical basis for pharmacological intervention as a reprogramming strategy against hypertension and kidney disease of developmental origin. Biochemical Pharmacology 153:82-90, 2018 (SCI; IF=4.235; Pharmacology & Pharmacy 36/261= 13.8%)
26. Tain YL, Lee WC, Wu K, Leu S, Chan JYH. Maternal high fructose intake increases the vulnerability to post-weaning high-fat diet induced programmed hypertension in male offspring. Nutrients 10:56, 2018 (IF=4.546, Nutrition & Dietetics 17/89= 19.1%)
27. Tain YL, Wu K, Lee WC, Leu S, Chan JYH. Prenatal metformin therapy attenuates hypertension of developmental origin in male adult offspring exposed to maternal high-fructose and post-weaning high-fat diets. Int. J. Mol. Sci. 19(4). pii: E1066, 2018 (SCI; IF=4.556; Biochemistry & Molecular Biology 74/297= 24.9%)
28. Tain YL, Leu S, Lee WC, Wu K, Chan JYH. Maternal Melatonin Therapy Attenuated Maternal High-Fructose Combined with Post-weaning High-Salt Diets-Induced Hypertension in Adult Male Rat Offspring. Molecules 23, 886, 2018 (IF=3.267, Chemistry, Multidisciplinary 70/177= 39.5%)
29. Tain YL, Lee WC, Wu K, Leu S, Chan JYH. Resveratrol prevents the development of hypertension programmed by maternal plus post-weaning high-fructose consumption through modulation of oxidative stress, nutrient-sensing signals, and gut microbiota. Mol Nutr Food Res. 62(15): e1800066, 2018 (SCI; IF=5.309; Food Science & Technology 8/139= 5.8%)
30. Tain YL, Hsu CN. AMP-Activated Protein Kinase as a Reprogramming Strategy for Hypertension and Kidney Disease of Developmental Origin. Int J Mol Sci 2018, 19, 1744 (SCI; IF=4.556; Biochemistry & Molecular Biology 74/297= 24.9%)
31. Tain YL, Hsu CN. Developmental Programming of the Metabolic Syndrome: Can We Reprogram with Resveratrol? Int J Mol Sci 2018, 19, 2854 (SCI; IF=4.556; Biochemistry & Molecular Biology 74/297= 24.9%)
32. Tain YL, Chan JYH, Lee CT, Hsu CN. Maternal Melatonin Therapy Attenuates Methyl-Donor Diet-Induced Programmed Hypertension in Male Adult Rat Offspring. Nutrients. 2018 Oct 2;10(10). pii: E1407. (IF=4.546, Nutrition & Dietetics 17/89= 19.1%)

Corresponding author publications (2015-2020)

1. Hsu CN, Lee CT, Huang LT, Tain YL*. Aliskiren in early postnatal life prevents hypertension and reduces asymmetric dimethylarginine in offspring exposed to maternal caloric restriction. J Renin Angiotensin Aldosterone Syst. 16(3) 506–513, 2015 (SCI; IF=1.197; Peripheral vascular disease 58/65= 89.2%)
2. Sheen JM, Yu HR, Tiao MM, Chen CC, Huang LT, Chang HY, Tain YL*. Prenatal dexamethasone-induced programmed hypertension and renal programming. Life Sci. 132: 41-48, 2015 (SCI; IF=3.647; Medicine Research & Experimental 54/138= 39.1%)
3. Chien SJ, Lin IC, Hsu CN, Lo MH, Tain YL*. Homocysteine and arginine-to-asymmetric dimethylarginine ratio associated with blood pressure abnormalities in children with early chronic kidney disease. Cir J 79: 2031-7, 2015 (SCI; IF=2.54; Cardiac & Cardiovascular Systems 64/138= 46.4%)
4. Lin IC, Hsu CN, Lo MH, Chien SJ, Tain YL*. Low urinary citrulline/arginine ratio associated with blood pressure abnormalities and arterial stiffness in childhood chronic kidney disease. J Am Soc Hypertens 10(2):115-23, 2016 (SCI; IF=2.615; Peripheral Vascular Disease 35/65= 53.8%)
5. Tai IH, Sheen JM, Lin YJ, Yu HR, Tiao MM, Chen CC, Huang LT, Tain YL*. Maternal N-acetylcysteine therapy regulates hydrogen sulfide-generating pathway and prevents programmed hypertension in male offspring exposed to prenatal dexamethasone and postnatal high-fat diet. Nitric Oxide 53: 6-12, 2016. (SCI; IF=3.311; Biochemistry & Molecular Biology 136/297= 45.8%)
6. Yu HR, Li SC, Tseng WN, Tain YL*, Chen CC, Tiao MM, Kuo HC, Huang CC, Hsieh KS, Huang LT*. Early and late effects of prenatal corticosteroid treatment on the microRNA profiles of lung tissue in rats. Exp Ther Med. 11(3): 753-762, 2016 (SCI; IF=1.410; Medicine, Research and Experimental 108/133= 81.2%)
7. Chang HY, Tain YL*. Postnatal dexamethasone-induced programmed hypertension is related to the regulation of melatonin and its receptors. Steroids 108:1-6, 2016 (SCI; IF=2.523; Biochemistry & Molecular Biology 175/292= 59.9%)
8. Hsu CN, Lee CT, Su CH, Wang YC, Chen HL, Cheung JH, Tain YL*. “Incidence, Outcomes and Risk Factors of Community-Acquired and Hospital-Acquired Acute Kidney Injury: A Retrospective Cohort Study. Medicine (Baltimore). 95(19):e3674, 2016. (SCI; IF=1.552; Medicine, General & Internal 89/165= 53.9%)
9. Lu PC, Sheen JM, Yu HR, Lin YJ, Chen CC, Tiao MM, Tsai CC, Huang LT, Tain YL*. Early postnatal treatment with soluble epoxide hydrolase inhibitor or 15-Deoxy-Δ12,14-prostagandin J2 prevents prenatal dexamethasone and postnatal high saturated fat diet induced programmed hypertension in adult rat offspring. Prostaglandins Other Lipid Mediat 124:1-8, 2016 (SCI; IF=2.932; Biochemistry & Molecular Biology 165/297= 55.6%)
10. Hsu CN, Wu KL, Lee WC, Leu S, Chan J, Tain YL*. Aliskiren administration during early postnatal life sex-specifically alleviates hypertension programmed by maternal high fructose consumption. Front Physiol. 7:299, 2016 (IF=3.394, Physiology 20/83= 24.1%)
11. Lin YJ, Tsai CC, Huang LT, Sheen JM, Tiao MM, Yu HR, Chen CC, Tain YL*. Detrimental effect of maternal and post-weaning high-fat diet on the reproductive function in the adult female offspring rat: roles of insulin-like growth factor 2 and the ovarian circadian clock. J Assist Reprod Genet 34:817-26, 2017 (SCI, IF=2.829; Reproductive Biology 14/29= 48.3%)
12. Hsu CN, Lin YJ, Lu PC, and Tain YL*. Early supplementation of D-cysteine or L-cysteine prevents hypertension and kidney damage in spontaneously hypertensive rats exposed to high-salt intake. Mol Nutr Food Res. 62(2):1700596, 2018. (SCI; IF=5.309; Food Science & Technology 8/139= 5.8%)
13. Lin YJ, Lin IC, Yu HR, Sheen JM, Huang LT, Tain YL*. Early postweaning treatment with dimethyl fumarate prevents prenatal dexamethasone and postnatal high fat diet induced programmed hypertension in male rat offspring, Oxid. Med. Cell Longev. 2018, Volume 2018, Article ID 5343462. (SCI; IF=5.076; Cell Biology 56/195= 28.7%)
14. Hsu CN, Chen HL, Tain YL*. Epidemiology and outcomes of community-acquired and hospital-acquired acute kidney injury in children and adolescents. Pediatr Res. 83(3):622-629, 2018 (SCI; IF=2.747; Pediatrics 24/128= 18.8%)
15. Lo MH, Lin IC, Lu PC, Huang CF, Chien SJ, Hsieh KS, Tain YL*. Evaluation of endothelial dysfunction, endothelial plasma markers, and traditional metabolic parameters in children with adiposity. J Formos Med Assoc. 118: 83-91, 2019 (SCI; IF=3.008; Medicine, general & internal 42/165= 25.5%)
16. Lee WC, Wu KLH, Leu S, Tain YL*. Translational insights on developmental origins of metabolic syndrome: focus on fructose consumption. Biomedical J. 41(2):96-101, 2018 (SCI; IF=3.697; Biochemistry & Molecular Biology 114/297= 38.4%).
17. Hsu CN, Lin HW, Pickard AS, and Tain YL*. EQ-5D-Y for the assessment of health-related quality of life among Taiwanese youth with mild-to-moderate chronic kidney diseas. Int J Qual Health Care. 30(4): 298-305, 2018. (SCI; IF=1.957; Health Policy & Services 44/87= 50.1%)
18. Hsu, CN, Lai WT, Lin YJ, Tain YL*. Postnatal high-fat diet sex-specifically exacerbates prenatal dexamethasone-induced hypertension: Mass spectrometry-based quantitative proteomic approach. J Nutr Biochem. 57:268-275. (IF=4.873, Nutrition & Dietetics 15/89= 16.9%)
19. Hsu CN, Tain YL*. Hydrogen Sulfide in Hypertension and Kidney Disease of Developmental Origins. Int J Mol Sci 2018, 19, 1438 (SCI; IF=4.556; Biochemistry & Molecular Biology 74/297= 24.9%)
20. Hsu CN, Lin YJ, Lu PC, Tain YL*. Maternal Resveratrol Therapy Protects Male Rat Offspring against Programmed Hypertension Induced by TCDD and Dexamethasone Exposures: Is It Relevant to Aryl Hydrocarbon Receptor? Int J Mol Sci 2018, 19(8). pii: E2459. (SCI; IF=4.556; Biochemistry & Molecular Biology 74/297= 24.9%)
21. Hsu CN, Lin YJ, Hou CY, Tain YL*. Maternal Administration of Probiotic or Prebiotic Prevents Male Adult Rat Offspring against Developmental Programming of Hypertension Induced by High Fructose Consumption in Pregnancy and Lactation. Nutrients 10:1229, 2018 (IF=4.546, Nutrition & Dietetics 17/89= 19.1%)
22. Hsu CN, Lu PC, Lo MH, Lin IC, Chang-Chien GP, Lin S, Tain YL. Gut Microbiota-Dependent Trimethylamine N-Oxide Pathway Associated with Cardiovascular Risk in Children with Early-Stage Chronic Kidney Disease. Int J Mol Sci 2018, 19, 3699. (SCI; IF=4.556; Biochemistry & Molecular Biology 74/297= 24.9%)
23. Hsu CN, Tain YL* The Double-edged Sword Effects of Maternal Nutrition in Developmental Programming of Hypertension. Nutrients 10:1917, 2018 (IF=4.546, Nutrition & Dietetics 17/89= 19.1%)
24. Lo MH, Lin IC, Lu PC, Huang CF, Chien SJ, Hsieh KS, Tain YL. Evaluation of endothelial dysfunction, endothelial plasma markers, and traditional metabolic parameters in children with adiposity. J Formos Med Assoc. 2019 Jan;118(1 Pt 1):83-91. (SCI; IF=3.008; Medicine, general & internal 42/165= 25.5%)
25. Hsu CN, Huang SH, Tain YL*. Adherence to long-term use of renin-angiotensin II-aldosterone system inhibitors in children with chronic kidney disease. BMC Pediatr. 2019 Feb 20;19(1):64. (SCI, IF= 1.909; Pediatrics 59/128=46.1%)
26. Hsu CN, Tain YL. Regulation of Nitric Oxide Production in the Developmental Programming of Hypertension and Kidney Disease. Int J Mol Sci. 2019 Feb 5;20(3):681. (SCI; IF=4.556; Biochemistry & Molecular Biology 74/297= 24.9%)
27. Lin YJ, Huang LT, Tsai CC, Sheen JM, Tiao MM, Yu HR, Lin IC, Tain YL. Maternal high-fat diet sex-specifically alters placental morphology and transcriptome in rats: Assessment by next-generation sequencing. Placenta. 2019 Mar;78:44-53. (SCI; IF=3.177; OBSTETRICS & GYNECOLOGY 18/82= 22%)
28. Hsu CN, Tain YL. The Good, the Bad, and the Ugly of Pregnancy Nutrients and Developmental Programming of Adult Disease. Nutrients. 2019 Apr 20;11(4):894. (IF=4.546, Nutrition & Dietetics 17/89= 19.1%)
29. Hsu CN, Tain YL. Impact of Arginine Nutrition and Metabolism during Pregnancy on Offspring Outcomes. Nutrients. 2019 Jun 27;11(7):1452. (IF=4.546, Nutrition & Dietetics 17/89= 19.1%)
30. Hsu CN, Lu PC, Hou CY, Tain YL. Blood Pressure Abnormalities Associated with Gut Microbiota-Derived Short Chain Fatty Acids in Children with Congenital Anomalies of the Kidney and Urinary Tract. J Clin Med. 2019 Jul 24;8(8):1090. (SCI; IF=3.303; Medicine, general & internal 36/165= 21.8%)
31. Chen HE, Lin YJ, Lin IC, Yu HR, Sheen JM, Tsai CC, Huang LT, Tain YL. Resveratrol prevents combined prenatal NG-Nitro-L-arginine-methyl ester (L-NAME) treatment plus postnatal high-fat diet induced programmed hypertension in adult rat offspring: Interplay between nutrient-sensing signals, oxidative stress and gut microbiota. J Nutr Biochem. 2019 Aug;70:28-37. (IF=4.873, Nutrition & Dietetics 15/89= 16.9%)
32. Hsu CN, Lin YJ, Yu HR, Lin IC, Sheen JM, Huang LT, Tain YL. Protection of Male Rat Offspring against Hypertension Programmed by Prenatal Dexamethasone Administration and Postnatal High-Fat Diet with the Nrf2 Activator Dimethyl Fumarate during Pregnancy. Int J Mol Sci. 2019 Aug 14;20(16):3957. (SCI; IF=4.556; Biochemistry & Molecular Biology 74/297= 24.9%)
33. Hsu CN, Hou CY, Lee CT, Chan JYH, Tain YL. The Interplay between Maternal and Post-Weaning High-Fat Diet and Gut Microbiota in the Developmental Programming of Hypertension. Nutrients. 2019 Aug 22;11(9):1982. (IF=4.546, Nutrition & Dietetics 17/89= 19.1%)
34. Hsu CN, Chang-Chien GP, Lin S, Hou CY, Tain YL. Targeting on Gut Microbial Metabolite Trimethylamine-N-Oxide and Short-Chain Fatty Acid to Prevent Maternal High-Fructose-Diet-Induced Developmental Programming of Hypertension in Adult Male Offspring. Mol Nutr Food Res. 2019 Sep;63(18):e1900073. (SCI; IF=5.309; Food Science & Technology 8/139= 5.8%)
35. Hsu CN, Lin YJ, Tain YL. Maternal Exposure to Bisphenol A Combined with High-Fat Diet-Induced Programmed Hypertension in Adult Male Rat Offspring: Effects of Resveratrol. Int J Mol Sci. 2019 Sep 6;20(18):4382. (SCI; IF=4.556; Biochemistry & Molecular Biology 74/297= 24.9%)
36. Hsu CN, Lu PC, Lo MH, Lin IC, Tain YL. The Association between Nitric Oxide Pathway, Blood Pressure Abnormalities, and Cardiovascular Risk Profile in Pediatric Chronic Kidney Disease. Int J Mol Sci. 2019 Oct 24;20(21):5301. (SCI; IF=4.556; Biochemistry & Molecular Biology 74/297= 24.9%)
37. Hsu CN, Huang LT, Tain YL. Perinatal Use of Melatonin for Offspring Health: Focus on Cardiovascular and Neurological Diseases. Int J Mol Sci. 2019 Nov 13;20(22):5681. (SCI; IF=4.556; Biochemistry & Molecular Biology 74/297= 24.9%)
38. Hsu CN, Hou CY, Chan JYH, Lee CT, Tain YL. Hypertension Programmed by Perinatal High-Fat Diet: Effect of Maternal Gut Microbiota-Targeted Therapy. Nutrients. 2019 Dec 2;11(12):2908. (IF=4.546, Nutrition & Dietetics 17/89= 19.1%)
39. Tsai WL, Hsu CN, Tain YL. Whether AICAR in Pregnancy or Lactation Prevents Hypertension Programmed by High Saturated Fat Diet: A Pilot Study. Nutrients. 2020 Feb 11;12(2):448. (IF=4.546, Nutrition & Dietetics 17/89= 19.1%)
40. Hsu CN, Tain YL. Early-Life Programming and Reprogramming of Adult Kidney Disease and Hypertension: The Interplay between Maternal Nutrition and Oxidative Stress. Int J Mol Sci. 2020 May 18;21(10):E3572. (SCI; IF=4.556; Biochemistry & Molecular Biology 74/297= 24.9%)
41. Hsu CN, Tain YL. Light and Circadian Signaling Pathway in Pregnancy: Programming of Adult Health and Disease. Int J Mol Sci. 2020 Mar 23;21(6):2232. (SCI; IF=4.556; Biochemistry & Molecular Biology 74/297= 24.9%)
42. Hsu CN, Tain YL. Amino Acids and Developmental Origins of Hypertension. Nutrients. 2020 Jun 12;12(6):1763. (IF=4.546, Nutrition & Dietetics 17/89= 19.1%)
43. Hsu CN, Lin IC, Yu HR, Huang LT, Tiao MM, Tain YL. Maternal Tryptophan Supplementation Protects Adult Rat Offspring against Hypertension Programmed by Maternal Chronic Kidney Disease: Implication of Tryptophan-Metabolizing Microbiome and Aryl Hydrocarbon Receptor. Int J Mol Sci. 2020, 21, 4552. (SCI; IF=4.556; Biochemistry & Molecular Biology 74/297= 24.9%)
44. Hsu CN, Chan JYH, Yu HR, Lee WC, Wu KLH, Chang-Chien GP, Lin S, Hou CY, Tain YL. Targeting on Gut Microbiota-Derived Metabolite Trimethylamine to Protect Adult Male Rat Offspring against Hypertension Programmed by Combined Maternal High-Fructose Intake and Dioxin Exposure. Int. J. Mol. Sci. 2020, 21, 5488. (SCI; IF=4.556; Biochemistry & Molecular Biology 74/297= 24.9%)

研究助理: 吳靜芬、陳宥葳、吳昕頻、黃渟詅

Education:

Degree: M.D., M.S., Ph.D.

1985-1992        M.D., China Medical College, Taiwan
1999-2002        Master of science degree in Graduate Institute of Clinical Medicine, Chang Gung University, Taiwan
2003-2004        Ph.D. graduate program, Department of Physiology and Pharmacology, Morgantown,
West Virginia, USA (Transfer to UF)
2004-2007        Ph.D. Physiology and Pharmacology concentration, Department of Physiology and Functional genomics,
College of Medicine, University of Florida, Gainesville, Florida, USA

Employment Record :

1994-1996       Residency training in Pediatrics, Chang Gung Memorial Hospital (CGMH)-Kaohsiung, Taiwan
1997-1998       Fellow training in Pediatric Nephrology, Chang Gung Children Hospital, Taiwan
1998-1999       Fellow training in Nephrology at CGMH-Kaohsiung, Taiwan
1999-2002       Attending Pediatrician & Director of Pediatric Nephrology at CGMH-Kaohsiung, Taiwan
2008-                Attending Pediatrician at CGMH-Kaohsiung, Taiwan
2009-2012        Assisstant Professor  at Kaohsiung CGMH, Taiwan
2009-               Physician Scientist at Kaohsiung CGMH, Taiwan
2011-               Deputy Director, Department of Pediatrics, Kaohsiung CGMH, Taiwan
2012-2015        Associate Professor, Department of Pediatrics, Kaohsiung CGMH, Taiwan
2013-                Associate Professor, College of Medicine, Chang Gung University, Taiwan
2015-                Professor, Department of Pediatrics, Kaohsiung CGMH, Taiwan
2017-                Director, Department of Medical Research and Development
2018-                Professor, College of Medicine, Chang Gung University, Taiwan

Board Certification :

1998                 Diploma of the Board of the Pediatrics, Taiwan; Certification No. 3362
1999                 Diploma of the Board of the Nephrology, Taiwan; Certification No. 600
2008                 Diploma of the expertise of Ultrasonography in Pediatrics,
Board of the Society of Ultrasound in Medicine of the ROC; Certification No. eP-000246

Professional Affiliations:

Taiwan Pediatric Association
Taiwan Society of Nephrology
The Society of Ultrasound in Medicine of the ROC
Asian Society for Pediatric Research (ASPR)
Taiwan DOHaD Society
Editorial Board, BioMed Research International (2013-until now)
Editorial Board, World Journal of Translational Medicine (2011-until now)
Editorial Board, ISRN Pediatrics (2013-until now)
Editorial Board, International Review of Molecular Sciences (2015-until now)

Research Interest:

DOHaD, Pediatric Nephrology, Renal Physiology, Free Radical Medicine, Hypertension.

五年內研究計畫 Research Project (2015-2020): 41件

擔任計畫主持人: 27件

1. NSC 101-2314-B-182A-021-MY3 (from National Science Council, Taiwan): ADMA/NO pathway in the developmental programming of kidney disease and hypertension (2012.08-2015.07)
2. CMRPG8C0631 (from CGMH): Methylation biosignature in childhood chronic kidney disease: the link among asymmetric dimethylarginine, homocysteine, and cardiovascular disease (2013.10-2016.9)
3. CMRPG8D0271 (from CGMH): The interrelations among ADMA, RAS, and H2S in the development of hypertension. (2014.06-2015.05)
4. CMRPG8D0201 & CMRPG8D0202 (from CGMH): Effects of prenatal dexamethasone exposure and postnatal high-fat diet on the development of adult kidney disease and hypertension: the links between endothelium-derived hyperpolarizing factors (EDHF). (2014.06-2016.05)
5. CMRPG8E0191 (from CGMH): Effects of aliskiren in early postnatal life and sex difference on the hypertension in offspring exposed to maternal high fructose intake (2015.06-2016.05)
6. MOST 104-2314-B-182 -056 -MY3 (from MOST): Impact of Melatonin in Programmed Hypertension and Kidney Disease: interrelationship among Oxidative Stress, Epigenetic Regulation, and Circadian Clock (2015.08-2018.07)
7. CMRPG8E0201 (from CGMH): Identifying biomarkers and cardiovascular risk factors in childhood metabolic syndrome. (2015.08-2017.07)
8. CMRPG8F0021/CMRPG8F0022/CMRPG8F0023 (from CGMH): Effects of postnatal nutritional insults on nutrient-sensing mechanisms and developmental programming increase later life vulnerability to hypertension and metabolic syndrome exposed to prenatal high-fructose (2016.04-2019.03)
9. CMRPG8F0161 (from CGMH): Effects of postnatal high-fat on the RAS, oxidative stress, and inflammation to increase later life vulnerability to hypertension and metabolic syndrome exposed to prenatal insults (2016.06-2017.05)
10. CMRPG8F0251 (from CGMH): Effects of hydrogen sulfide from L- or D-cysteine in spontaneously hypertensive rats fed with a high-salt intake (2016.06-2017.05)
11. CORPG8F1031/ CORPG8F1032/CORPG8F1033 (from CGMH): Cardiovascular comorbidity in children with chronic kidney disease: identification of novel biomarkers and therapeutic targets (2016.11-2019.10)
12. CMRPG8G0151 (from CGMH): Programmed hypertension induced by maternal stress and EDC exposures: The interplay between aryl hydrocarbon receptor, oxidative stress, and RAS (2017.07-2018.06)
13. CMRPG8G0191 (from CGMH): Maternal high-fructose consumption induces programmed hypertension in adult offspring: the link among nutrient-sensing signals, gut microbiota, and sensory receptors (2017.07-2018.06)
14. CMRPG8G0671 (from CGMH): Developmental programming of hypertension: interplay between high-fat intake, peroxisome proliferator-activated receptors (ppars), oxidative stress, and nutrient-sensing signals (2017.07-2018.06)
15. CMRPG8H0081 (from CGMH): The role of gut microbiota, trimethylamine-N-oxide, and short chain fatty acid in the developmental programming of hypertension. (2018.01-2018.12)
16. MOST 107-2314-B-182 -045 -MY3 (From MOST): Reprogramming strategy against hypertension of developmental origin: Targeted metabolomics in gut microbiota (2018.08-2021.07)
17. CMRPG8H0641 (from CGMH): Programmed hypertension induced by maternal high-fat diet and bisphenol A exposure: The Interplay between aryl hydrocarbon receptor signals and nitric oxide pathway. (2018.09-2019.08)
18. CMRPG8H0831 (from CGMH): Prevention of maternal and post-weaning high-fat diet-induced programmed hypertension by AICAR. (2018.09-2019.08)
19. CMRPG8I0101 (from CGMH): The impact of gut microbiota-dependent trimethylamine N-oxide (TMAO) and short chain fatty acids on cardiovascular comorbidity in children with chronic kidney disease. (2019.01-2019.12)
20. CMRPG8J0251/ CMRPG8J0252/CMRPG8J0253 (from CGMH): The cross-talk between the kidney and the gut: implications for developmental programming of hypertension induced by maternal high-fructose diet. (2019.05-2022.04)
21. CORPG8J0121 (from CGMH): The Interplay between Hydrogen Sulfide and Gut Microbiota in the Development of Hypertension (2019.10-2020.09)
22. CMRPG8K0141 (from CGMH): Therapeutic use of garlic oil during pregnancy and lactation prevents the developmental programming of hypertension in male offspring of mother exposed to high-fat diet (2020.01-2020.12)
23. CMRPG8K0211 (from CGMH): The role of gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) pathway in hypertension programmed by maternal chronic kidney disease: Biosensor development. (2020.01-2020.12)
24. CMRPG8K0721 (from CGMH): Early Life Origins of Kidney Disease and Hypertension: A Precision Medicine Approach to Cardiovascular Health for Children with Chronic Kidney Disease (2020.01-2020.12)
25. CMRPG8J0891 (from CGMH): The interactions between gut microbiota, microbial metabolites, and aryl hydrocarbon receptor signaling in the developmental programming of hypertension and kidney disease (2019.10-2020.09)
26. CLRPG8I0021/ CLRPG8I0022 (from CGMH): 研究區安全衛生檢核、教育訓練及運作管理之品質改善計畫 (2019.02-2021.01)
27. CMRPG8K1011 (from CGMH): The role of melatonin in adenine-induced chronic kidney disease: measurement of cystatin C using microneedle patch. (2020.07-2021.06

擔任計畫共同主持人: 14件

1. NSC 101-2314-B-182A-053-MY3 (from National Science Council, Taiwan): 親蛋白質尿毒素之血管與腎毒性 (2012.08-2015.07)
2. 四年期國衛院計畫NHRI-EX102-10227PC (2013.01- 2016.12): 兒童及青少年慢性腎臟病用藥之長期效果研究
3. CMRPG8D0281 (from CGMH): The effect of melatonin on ADMA and H2S in spontaneously hypertensive rat. (2014.06-2015.05)
4. CMRPG8D0211 (from CGMH): Effect of prenatal dexamethasone-induced hypertension on melatonin receptors. (2014.06-2015.05)
5. CMRPG8D0331 (from CGMH): Nitric oxide and arterial stiffness in childhood obesity. (2014.07-2015.06)
6. CMRPG8E0091 (from CGMH): Gender difference on prenatal dexamethasone induced programmed hypertension and renal programming. (2015.06-2016.05)
7. CMRPG8E0321 (from CGMH): The impact of maternal high-fat diet and postnatal high-fat diet on fetal growth and reproductive function in rat offspring. (2015.07-2016.06)
8. MOST 104-2314-B-182A-143- (from MOST): Vascular calcification in chronic kidney disease: novel mechanism and potential treatment (2015.08-2016.07)
9. CMRPG8F0291 (from CGMH): Sex-specific effect of melatonin on prenatal dexamethasone and postnatal high-fat diet induced hypertension and melatonin receptors. (2016.06-2017.05)
10. MOST 105-2314-B-182A-089-MY3 (from MOST): The MicroRNA regulation and BMP/Wnt Signaling in Chronic Kidney Disease-associated Vascular Calcification (2016.08-2019.07)
11. MOST 106-2314-B-182A-021 (from MOST) Diffusion Tensor Imaging and T2-mapping as in vivo Biomarkers for Assessing Hypertensive Nephropathy in DOCA-salt-induced and Spontaneous Hypertensive Rats and Effects of Melatonin Treatment. (2017.08-2018.07)
12. 108-2221-E-992 -046 – (from MOST) 再生營養：運用循環再生概念酯化葡萄酒渣中白藜蘆醇之轉化條件、結構穩定及其健康功能應用. (2019.08-2020.07)
13. 108-2314-B-182A-043 -MY3 (from MOST) 從致病機轉研究慢性腎臟病血管鈣化的預防. (2019.08-2022.07)
14. 109-2221-E-992 -051 -(from MOST) 白藜蘆醇酯化衍物在抗脂肪堆積之代謝機轉探討. (2020.08-2021.07)

Publication List:

Check the list of my all publications in ORCID: https://orcid.org/0000-0002-7059-6407