成員介紹

Selected recent publications (Pubmed Search)
 († Contributed equally to the article; * Correspondence author of the article)

1. Tsai CY*, Lee CL, Wu JCC. Astrocyte-secreted lipocalin-2 elicits bioenergetic failure-induced neuronal death that is causally related to high fatality in a mouse model of hepatic encephalopathy. Neurochem Int 178, 105800 (2024).
2. Tsai CY*, Wu JCC, Wu CJ, Chan SHH. Protective role of VEGF/VEGFR2 signaling against high fatality associated with hepatic encephalopathy via sustaining mitochondrial bioenergetics functions. J Biomed Sci 29(1): 47 (2022).
3. Tsai CY*, Fang C, Wu JCC, Wu CJ, Dai KY, Chen SM. Neuroinflammation and microglial activation at rostral ventrolateral medulla underpin cadmium-induced cardiovascular dysregulation in rats. Journal of Inflammation Research 14, 3863-3877 (2021).
4. Poon YY^†, Tsai CY^†, Huang YH, Wu JCC, Chan SHH, Chan JYH. Disproportional cardiovascular depressive effects of isoflurane: Serendipitous findings from a comprehensive re-visit in mice. Lab Anim (NY) 50, 26-31 (2021).
5. Tsai CY*, Wu CJ, Wu JCC, Fang C, Huang YH, Dai KY. Redox-active DJ-1 sustains brainstem cardiovascular regulation via maintenance of mitochondrial function during mevinphos intoxication. Neurochem Int 139, 104791 (2020).
6. Chen SM, Phuagkhaopong S, Fang C, Wu JCC, Huang YH, Vivithanaporn P, Lin HH, Tsai CY*. Dose-dependent acute circulatory fates elicited by cadmium are mediated by differential engagements of cardiovascular regulatory mechanisms in brain. Frontiers in Physiology 10, 772 (2019).
7. Tsai CY, Poon YY, Chan JYH, Chan SHH. Baroreflex functionality in the eye of diffusion tensor imaging. The Journal of Physiology 597, 41-55 (2019).
8. Tsai CY*, Dai KY, Fang C, Wu JCC, Chan SHH*. PTEN/FLJ10540/PI3K/Akt cascade in experimental brain stem death: A newfound role for a classical tumorigenic signaling. Biochemical Pharmacology, 155, 207-212 (2018).
9. Tsai CY*, Wu JCC, Fang C, Chang AYW. PTEN, a negative regulator of PI3K/Akt signaling, sustains brain stem cardiovascular regulation during mevinphos intoxication. Neuropharmacology 123: 175-185 (2017).
10. Tsai CY, Su CH, Chan JYH, Chan SHH*. Nitrosative stress-induced disruption of baroreflex neural circuits in a rat model of hepatic encephalopathy: a DTI study. Scientific Reports, 7: 40111 (2017).
11. Tsai CY, Li FCH, Wu CHY, Chang AYW*, Chan SHH*. Sumoylation of IκB attenuates NF-κB-induced nitrosative stress at rostral ventrolateral medulla and cardiovascular depression in experimental brain death. Journal of Biomedical Science, 23: 65 (2016).
12. Tsai CY^†, Chen CH^†, Chang AYW, Chan JYH, Chan SHH*. Upregulation of FLJ10540, a PI3K-association protein, in rostral ventrolateral medulla impairs brain stem cardiovascular regulation during mevinphos intoxication. Biochemical Pharmacology, 93: 34-41 (2015).

Education:

2009  Ph.D.  Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan
2004  B.S.   Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan

Professional Experience:

2019/8 ~ present Associate Professor, Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
2015/9 ~ 2019/7   Assistant Professor, Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
2009/9 ~ 2015/8   Postdoctoral Research Fellow, Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan

Awards and Honors:

2019    Editorial Board Fellow, The Journal of Physiology
2018    Awardee, Chang Gung Outstanding Young Medical Researcher Award, Chang Gung Medical
Foundation, Kaohsiung, Taiwan (長庚醫學研究獎-青年獎)
2016    Awardee, Young Investigator Award, Federation of Asian Societies for Molecular Imaging (FASMI) Annual Meeting, Kobe, Japan
2016    Travel Grants and Oral Speaker, the 13th Asia Pacific Federation of Pharmacologists (APFP) Meeting, Bangkok, Thailand
2013    Awardee, Outstanding Young Scientist Oral Presentation Award, the 12th meeting of the Asia Pacific Federation of Pharmacologists (APFP), Shanghai, China
2008    Awardee, Distinguished Postgraduate Student Research Award, the Pharmacological Society in Taiwan, Taiwan
2007    1st prize, SEAWP Poster Prize, the 10th Southeast Asian Western Pacific regional meeting of Pharmacologists (SEAWP), Adelaide, Australia
2006    Participant, the 9th International Brain Research Organization-Asia Pacific Regional Committee (IBRO-APRC) School of Neuroscience, Hong Kong, China

Professional Activities:

2021~  Associate Editor, Natural Sciences
2019    Symposium Organizer and Chair, the 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019), Kobe, Japan
2018~  Editorial Board, FASEB BioAdvances
2017    Invited Speaker, Young Investigator Colloquium, the International Society for Neurochemistry (ISN) 2017 Biennial Meeting, Paris, France
2014    Invited Speaker, Young Investigator Colloquium, the 12th meeting of the Asian Pacific Society for Neurochemistry (APSN), Kaohsiung, Taiwan
2012    Invited Speaker, Young Investigator Colloquium, the 11th meeting of the Asian Pacific Society for Neurochemistry (APSN), Kobe, Japan

Professional Societies:

American Physiological Society (APS)
International Society for Neurochemistry (ISN)
The Chinese Physiological Society
The Pharmacological Society in Taiwan

Research Interests:

1. Central Cardiovascular Regulation
2. Signal Transduction
3. Molecular Image
4. Pharmacology of pesticides and anesthetics
5. Redox signaling and oxidative stress