聯絡電話
楊政霖
教授
細胞和分子神經科學
神經細胞 DNA 修復
星形膠質細胞病理生理學
缺血性中風之治療與機制
- 電子郵件信箱
jyang@cgmh.org.tw
研究簡介
探討涉及調控神經細胞和星形膠質細胞中DNA修復蛋白的信號機轉是實驗室過去數年的研究主軸。我們的目標是為了解衰老、神經失調和缺血性中風等過程中產生DNA損傷的致病因子的機制，然後通過提高DNA修復效率來應對DNA損傷以增加神經細胞存活。開發神經系統疾病的治療方法是我們實驗室的最終目標。
目前，我的實驗室亦協助或與醫生合作發展新的實驗和計畫，試圖將神經退化性疾病、大腦缺血性中風、血管和腎性認知病變領域的基礎研究工作與的臨床治療聯繫起來。 此外，涉及神經發炎的星形膠質細胞和線粒體功能障礙也是目前的研究目標。
經由提高APE1表現而提高神經細胞氧化DNA修復效率
不再有絲分裂的神經細胞是高度分化的細胞，其表現出經常性興奮性電位訊號傳遞、高代謝率和大量的轉錄活性。這些細胞中的高代謝活性產生相對大量的活性氧物質 (ROS)，其可破壞脂質、蛋白質和DNA。由於神經細胞代謝率較高，其受到氧化反應的刺激而產生氧化性DNA損傷。細胞核DNA和線粒體DNA中，氧化性DNA損傷的累積是神經退化性疾病和正常衰老的病原體。因此，DNA修復能力對神經細胞的正常功能和存活至關重要。 鹼基切除修復（BER）途徑通常被認為是修復DNA的氧化損傷、脫氨、烷基化和單鏈斷裂的主要機制，其涉及多種酵素和路徑過程，例如DNA糖基化酶、脫嘌呤/脫嘧啶核酸內切酶1(APE1)、DNA聚合酶β和連接酶。我們之前的研究顯示，APE1能夠經由氧化反應、神經遞質(谷氨酸)、腦源性神經營養因子（BDNF）和類昇糖素胜肽-1 (GLP-1) 而增強，以提高DNA修復效率，並非BER的其他修復酶。我們的研究發現氧化反應、谷氨酸、BDNF和GLP-1的所有下游信號傳導都朝向CaMK-CREB或Akt-CREB訊號鏈以增強APE1之表現。我們提出CREB信號傳遞鏈為提高APE1表現和氧化DNA修復效率的重要途徑，可作為神經退行性疾病、缺血性中風、癲癇發作和許多其他神經系統疾病的治療方向。
星形膠質細胞在缺血性中風治療中的角色
星形膠質細胞是哺乳動物中樞神經系統（CNS）中最豐富的細胞，並且在維持動態平衡和大腦正常功能方面發揮多重作用。星形膠質細胞的細胞和分子內容物、形態和功能會受各種CNS損傷而改變，而被稱為“反應性星形膠質細胞”。反應性星形膠質細胞的作用尚未明確定義，其對CNS損傷後的恢復有好有壞。星形膠質細胞的所有生理和細胞特性包括耐缺氧、分泌神經營養因子、抗興奮性毒性、神經膠質瘢痕形成、介導神經細胞生成和突觸生成、增強血管生成、維持BBB功能等，都顯示出星形膠質細胞是缺血性中風、甚至其他神經系統疾病的潛在治療標的。我們目前的研究已經觀察到缺血性中風周邊區 (penumbral area) 的星形膠質細胞能夠轉分化成放射狀膠質細胞，我們正在研究涉及星形膠質細胞存活和轉分化的可能機制。提高星形膠質細胞活力並有效調節反應性星形膠質細胞對缺血性中風後的有益影響可能是開發治療方法的新方向。
學術著作
Recent publications (Pubmed Search)
1: Wong LS, Yang JL, Yen YT, Lee CH, Yang JH. Endothelin-1 Participates in the
Pathogenesis of Prurigo Nodularis by Promoting NGF Expression via Endothelial
Receptor B in Epidermal Keratinocytes and Dorsal Root Ganglion Cells. Allergy.
2025 May;80(5):1530-1533. doi: 10.1111/all.16564. Epub 2025 Apr 18. PMID:
40249388; PMCID: PMC12105065.
2: Pe LS, Pe KCS, Panmanee J, Govitrapong P, Yang JL, Mukda S. Plausible
therapeutic effects of melatonin and analogs in the dopamine-associated
pathophysiology of bipolar disorder. J Psychiatr Res. 2025 Feb;182:13-20. doi:
10.1016/j.jpsychires.2024.12.046. Epub 2025 Jan 2. PMID: 39793267.
3: Yang JL, Lin WL, Tai SB, Ciou YS, Chung CL, Chen JJ, Liu PF, Lin MW, Chen CL.
Suppression of TGFβ-Induced Interleukin-6 Secretion by Sinulariolide from Soft
Corals through Attenuation of the p38-NF-kB Pathway in Carcinoma Cells. Int J
Mol Sci. 2023 Jul 19;24(14):11656. doi: 10.3390/ijms241411656. PMID: 37511415;
PMCID: PMC10380600.
4: Chen CY, Chao YM, Cho CC, Chen CS, Lin WY, Chen YH, Cassar M, Lu CS, Yang JL,
Chan JYH, Juo SH. Cerebral Semaphorin3D is a novel risk factor for age-
associated cognitive impairment. Cell Commun Signal. 2023 Jun 14;21(1):140. doi:
10.1186/s12964-023-01158-5. PMID: 37316917; PMCID: PMC10265764.
5: Chen SD, Chuang YC, Lin TK, Yang JL. Alternative role of glucagon-like
Peptide-1 receptor agonists in neurodegenerative diseases. Eur J Pharmacol. 2023
Jan 5;938:175439. doi: 10.1016/j.ejphar.2022.175439. Epub 2022 Dec 2. PMID:
36470445.
6: Huang CC, Chou CA, Chen WY, Yang JL, Lee WC, Chen JB, Lee CT, Li LC.
Empagliflozin Ameliorates Free Fatty Acid Induced-Lipotoxicity in Renal Proximal
Tubular Cells via the PPARγ/CD36 Pathway in Obese Mice. Int J Mol Sci. 2021 Nov
17;22(22):12408. doi: 10.3390/ijms222212408. PMID: 34830289; PMCID: PMC8621539.
7: Huang CY, Yang JL, Chen JJ, Tai SB, Yeh YH, Liu PF, Lin MW, Chung CL, Chen
CL. Fluoroquinolones Suppress TGF-β and PMA-Induced MMP-9 Production in Cancer
Cells: Implications in Repurposing Quinolone Antibiotics for Cancer Treatment.
Int J Mol Sci. 2021 Oct 27;22(21):11602. doi: 10.3390/ijms222111602. PMID:
34769032; PMCID: PMC8584204.
8: Chen SD, Yang JL, Hsieh YH, Lin TK, Lin YC, Chao AC, Yang DI. Potential Roles
of Sestrin2 in Alzheimer’s Disease: Antioxidation, Autophagy Promotion, and
Beyond. Biomedicines. 2021 Sep 24;9(10):1308. doi: 10.3390/biomedicines9101308.
PMID: 34680426; PMCID: PMC8533411.
9: Chang CC, Silva BBI, Huang HY, Tsai CY, Flores RJD, Tayo LL, Tyan YC, Tsai
MA, Catulin GEM, Chuang KP, Yang JL. Development and Validation of KASP Assays
for the Genotyping of Racing Performance-Associated Single Nucleotide
Polymorphisms in Pigeons. Genes (Basel). 2021 Sep 3;12(9):1383. doi:
10.3390/genes12091383. PMID: 34573366; PMCID: PMC8468996.
10: Li LC, Chen WY, Chen JB, Lee WC, Chang CC, Tzeng HT, Huang CC, Chang YJ,
Yang JL. The AST-120 Recovers Uremic Toxin-Induced Cognitive Deficit via NLRP3
Inflammasome Pathway in Astrocytes and Microglia. Biomedicines. 2021 Sep
17;9(9):1252. doi: 10.3390/biomedicines9091252. PMID: 34572437; PMCID:
PMC8467651.
11: Tseng YJ, Lee CH, Chen WY, Yang JL, Tzeng HT. Inhibition of PAI-1 Blocks
PD-L1 Endocytosis and Improves the Response of Melanoma Cells to Immune
Checkpoint Blockade. J Invest Dermatol. 2021 Nov;141(11):2690-2698.e6. doi:
10.1016/j.jid.2021.03.030. Epub 2021 May 14. PMID: 34000287.
12: Tzeng HT, Yang JL, Tseng YJ, Lee CH, Chen WJ, Chyuan IT. Plasminogen
Activator Inhibitor-1 Secretion by Autophagy Contributes to Melanoma Resistance
to Chemotherapy through Tumor Microenvironment Modulation. Cancers (Basel). 2021
Mar 12;13(6):1253. doi: 10.3390/cancers13061253. PMID: 33809137; PMCID:
PMC7999393.
13: Tsai YH, Su CH, Lee IN, Yang JT, Lin LC, Huang YC, Yang JL. Effects of Early
Rehydration on Brain Perfusion and Infarct Core after Middle Cerebral Artery
Occlusion in Rats. Brain Sci. 2021 Mar 29;11(4):439. doi:
10.3390/brainsci11040439. PMID: 33805440; PMCID: PMC8066368.
14: Chen WY, Wu YH, Tsai TH, Li RF, Lai AC, Li LC, Yang JL, Chang YJ. Group 2
innate lymphoid cells contribute to IL-33-mediated alleviation of cardiac
fibrosis. Theranostics. 2021 Jan 1;11(6):2594-2611. doi: 10.7150/thno.51648.
PMID: 33456562; PMCID: PMC7806479.
15: Veschsanit N, Yang JL, Ngampramuan S, Viwatpinyo K, Pinyomahakul J, Lwin T,
Chancharoen P, Rungruang S, Govitrapong P, Mukda S. Melatonin reverts
methamphetamine-induced learning and memory impairments and hippocampal
alterations in mice. Life Sci. 2021 Jan 15;265:118844. doi:
10.1016/j.lfs.2020.118844. Epub 2020 Dec 2. PMID: 33278389.
16: Yang JL, Lin YT, Chen WY, Yang YR, Sun SF, Chen SD. The Neurotrophic
Function of Glucagon-Like Peptide-1 Promotes Human Neuroblastoma Differentiation
via the PI3K-AKT Axis. Biology (Basel). 2020 Oct 22;9(11):348. doi:
10.3390/biology9110348. PMID: 33105690; PMCID: PMC7690389.
17: Chen CY, Chao YM, Lin HF, Chen CJ, Chen CS, Yang JL, Chan JYH, Juo SH.
miR-195 reduces age-related blood-brain barrier leakage caused by
thrombospondin-1-mediated selective autophagy. Aging Cell. 2020
Nov;19(11):e13236. doi: 10.1111/acel.13236. Epub 2020 Oct 7. PMID: 33029941;
PMCID: PMC7681043.
18: Lwin T, Yang JL, Ngampramuan S, Viwatpinyo K, Chancharoen P, Veschsanit N,
Pinyomahakul J, Govitrapong P, Mukda S. Melatonin ameliorates methamphetamine-
induced cognitive impairments by inhibiting neuroinflammation via suppression of
the TLR4/MyD88/NFκB signaling pathway in the mouse hippocampus. Prog
Neuropsychopharmacol Biol Psychiatry. 2021 Dec 20;111:110109. doi:
10.1016/j.pnpbp.2020.110109. Epub 2020 Sep 15. PMID: 32941923.
19: Chen SD, Pan HY, Huang JB, Liu XP, Li JH, Ho CJ, Tsai MH, Yang JL, Chen SF,
Chen NC, Chuang YC. Circulating MicroRNAs from Serum Exosomes May Serve as a
Putative Biomarker in the Diagnosis and Treatment of Patients with Focal
Cortical Dysplasia. Cells. 2020 Aug 10;9(8):1867. doi: 10.3390/cells9081867.
PMID: 32785072; PMCID: PMC7465068.
20: Chen SD, Yang JL, Lin YC, Chao AC, Yang DI. Emerging Roles of Inhibitor of
Differentiation-1 in Alzheimer’s Disease: Cell Cycle Reentry and Beyond. Cells.
2020 Jul 21;9(7):1746. doi: 10.3390/cells9071746. PMID: 32708313; PMCID:
PMC7409121.
21: Chen WY, Li LC, Wu YH, Yang JL, Tzeng HT. Emerging Roles of
Interleukin-33-responsive Kidney Group 2 Innate Lymphoid Cells in Acute Kidney
Injury. Int J Mol Sci. 2020 Feb 24;21(4):1544. doi: 10.3390/ijms21041544. PMID:
32102434; PMCID: PMC7073188.
22: Yang JL, Yang YR, Chen SD. The potential of drug repurposing combined with
reperfusion therapy in cerebral ischemic stroke: A supplementary strategy to
endovascular thrombectomy. Life Sci. 2019 Nov 1;236:116889. doi:
10.1016/j.lfs.2019.116889. Epub 2019 Oct 11. PMID: 31610199.
23: Chen SD, Yang JL, Lin TK, Yang DI. Emerging Roles of Sestrins in
Neurodegenerative Diseases: Counteracting Oxidative Stress and Beyond. J Clin
Med. 2019 Jul 9;8(7):1001. doi: 10.3390/jcm8071001. PMID: 31324048; PMCID:
PMC6678886.
24: Mukda S, Tsai CY, Leu S, Yang JL, Chan SHH. Pinin protects astrocytes from
cell death after acute ischemic stroke via maintenance of mitochondrial anti-
apoptotic and bioenergetics functions. J Biomed Sci. 2019 Jun 5;26(1):43. doi:
10.1186/s12929-019-0538-5. PMID: 31167655; PMCID: PMC6549339.
25: Tsai YH, Yang JL, Lee IN, Yang JT, Lin LC, Huang YC, Yeh MY, Weng HH, Su CH.
Effects of Dehydration on Brain Perfusion and Infarct Core After Acute Middle
Cerebral Artery Occlusion in Rats: Evidence From High-Field Magnetic Resonance
Imaging. Front Neurol. 2018 Sep 20;9:786. doi: 10.3389/fneur.2018.00786. PMID:
30294297; PMCID: PMC6158308.
26: Li LC, Yang JL, Lee WC, Chen JB, Lee CT, Wang PW, Vaghese Z, Chen WY.
Palmitate aggravates proteinuria-induced cell death and inflammation via
CD36-inflammasome axis in the proximal tubular cells of obese mice. Am J Physiol
Renal Physiol. 2018 Dec 1;315(6):F1720-F1731. doi: 10.1152/ajprenal.00536.2017.
Epub 2018 Sep 19. PMID: 30230367.
27: Chen WY, Tsai TH, Yang JL, Li LC. Therapeutic Strategies for Targeting
IL-33/ST2 Signalling for the Treatment of Inflammatory Diseases. Cell Physiol
Biochem. 2018;49(1):349-358. doi: 10.1159/000492885. Epub 2018 Aug 23. PMID:
30138941.
28: Chen SD, Yang JL, Hwang WC, Yang DI. Emerging Roles of Sonic Hedgehog in
Adult Neurological Diseases: Neurogenesis and Beyond. Int J Mol Sci. 2018 Aug
16;19(8):2423. doi: 10.3390/ijms19082423. PMID: 30115884; PMCID: PMC6121355.
29: Chen WY, Yang JL, Wu YH, Li LC, Li RF, Chang YT, Dai LH, Wang WC, Chang YJ.
IL-33/ST2 axis mediates hyperplasia of intrarenal urothelium in obstructive
renal injury. Exp Mol Med. 2018 Apr 20;50(4):1-11. doi:
10.1038/s12276-018-0047-8. PMID: 29674622; PMCID: PMC5938009.
30: Yang JL, Mukda S, Chen SD. Diverse roles of mitochondria in ischemic stroke.
Redox Biol. 2018 Jun;16:263-275. doi: 10.1016/j.redox.2018.03.002. Epub 2018 Mar
9. PMID: 29549824; PMCID: PMC5854930.
31: Yang JL, Chen WY, Chen SD. The Emerging Role of GLP-1 Receptors in DNA
Repair: Implications in Neurological Disorders. Int J Mol Sci. 2017 Aug
26;18(9):1861. doi: 10.3390/ijms18091861. PMID: 28846606; PMCID: PMC5618510.
32: Chen WY, Li LC, Yang JL. Emerging Roles of IL-33/ST2 Axis in Renal Diseases.
Int J Mol Sci. 2017 Apr 7;18(4):783. doi: 10.3390/ijms18040783. PMID: 28387719;
PMCID: PMC5412367.
33: Yang JL, Chen WY, Chen YP, Kuo CY, Chen SD. Activation of GLP-1 Receptor
Enhances Neuronal Base Excision Repair via PI3K-AKT-Induced Expression of
Apurinic/Apyrimidinic Endonuclease 1. Theranostics. 2016 Sep 2;6(12):2015-2027.
doi: 10.7150/thno.15993. PMID: 27698937; PMCID: PMC5039677.
34: Chuang YC, Lin TK, Yang DI, Yang JL, Liou CW, Chen SD. Peroxisome
proliferator-activated receptor-gamma dependent pathway reduces the
phosphorylation of dynamin-related protein 1 and ameliorates hippocampal injury
induced by global ischemia in rats. J Biomed Sci. 2016 May 12;23(1):44. doi:
10.1186/s12929-016-0262-3. PMID: 27175924; PMCID: PMC4865999.
35: Chen WY, Chang YJ, Su CH, Tsai TH, Chen SD, Hsing CH, Yang JL. Upregulation
of Interleukin-33 in obstructive renal injury. Biochem Biophys Res Commun. 2016
May 13;473(4):1026-1032. doi: 10.1016/j.bbrc.2016.04.010. Epub 2016 Apr 8. PMID:
27067050.
36: Hsieh MC, Tsai CY, Liao MC, Yang JL, Su CH, Chen JH. Quantitative
Susceptibility Mapping-Based Microscopy of Magnetic Resonance Venography (QSM-
mMRV) for In Vivo Morphologically and Functionally Assessing
Cerebromicrovasculature in Rat Stroke Model. PLoS One. 2016 Mar
14;11(3):e0149602. doi: 10.1371/journal.pone.0149602. PMID: 26974842; PMCID:
PMC4790912.
37: Chuang YC, Yang JL, Yang DI, Lin TK, Liou CW, Chen SD. Roles of Sestrin2 and
Ribosomal Protein S6 in Transient Global Ischemia-Induced Hippocampal Neuronal
Injury. Int J Mol Sci. 2015 Nov 4;16(11):26406-16. doi: 10.3390/ijms161125963.
PMID: 26556340; PMCID: PMC4661822.
38: Tsai TH, Sun CK, Su CH, Sung PH, Chua S, Zhen YY, Leu S, Chang HW, Yang JL,
Yip HK. Sitagliptin attenuated brain damage and cognitive impairment in mice
with chronic cerebral hypo-perfusion through suppressing oxidative stress and
inflammatory reaction. J Hypertens. 2015 May;33(5):1001-13. doi:
10.1097/HJH.0000000000000529. PMID: 25689400.
39: Fan CQ, Leu S, Sheu JJ, Zhen YY, Tsai TH, Chen YL, Chung SY, Chai HT, Sun
CK, Yang JL, Chang HW, Ko SF, Yip HK. Prompt bone marrow-derived mesenchymal
stem cell therapy enables early porcine heart function recovery from acute
myocardial infarction. Int Heart J. 2014;55(4):362-71. doi: 10.1536/ihj.14-007.
Epub 2014 Jun 25. PMID: 24965596.
40: Yang JL, Lin YT, Chuang PC, Bohr VA, Mattson MP. BDNF and exercise enhance
neuronal DNA repair by stimulating CREB-mediated production of
apurinic/apyrimidinic endonuclease 1. Neuromolecular Med. 2014
Mar;16(1):161-174. doi: 10.1007/s12017-013-8270-x. Epub 2013 Oct 10. PMID:
24114393; PMCID: PMC3948322.
41: Chen YT, Yang CC, Zhen YY, Wallace CG, Yang JL, Sun CK, Tsai TH, Sheu JJ,
Chua S, Chang CL, Cho CL, Leu S, Yip HK. Cyclosporine-assisted adipose-derived
mesenchymal stem cell therapy to mitigate acute kidney ischemia-reperfusion
injury. Stem Cell Res Ther. 2013 May 31;4(3):62. doi: 10.1186/scrt212. PMID:
23726287; PMCID: PMC3706768.
42: Sykora P, Yang JL, Ferrarelli LK, Tian J, Tadokoro T, Kulkarni A, Weissman
L, Keijzers G, Wilson DM 3rd, Mattson MP, Bohr VA. Modulation of DNA base
excision repair during neuronal differentiation. Neurobiol Aging. 2013
Jul;34(7):1717-27. doi: 10.1016/j.neurobiolaging.2012.12.016. Epub 2013 Feb 1.
PMID: 23375654; PMCID: PMC5576894.
43: Cheng A, Wan R, Yang JL, Kamimura N, Son TG, Ouyang X, Luo Y, Okun E,
Mattson MP. Involvement of PGC-1α in the formation and maintenance of neuronal
dendritic spines. Nat Commun. 2012;3:1250. doi: 10.1038/ncomms2238. PMID:
23212379; PMCID: PMC4091730.
44: Sheu JJ, Lin KC, Tsai CY, Tsai TH, Leu S, Yen CH, Chen YL, Chang HW, Sun CK,
Chua S, Yang JL, Yip HK. Combination of cilostazol and clopidogrel attenuates
rat critical limb ischemia. J Transl Med. 2012 Aug 16;10:164. doi:
10.1186/1479-5876-10-164. PMID: 22897925; PMCID: PMC3479044.
45: Yang JL, Sykora P, Wilson DM 3rd, Mattson MP, Bohr VA. The excitatory
neurotransmitter glutamate stimulates DNA repair to increase neuronal
resiliency. Mech Ageing Dev. 2011 Aug;132(8-9):405-11. doi:
10.1016/j.mad.2011.06.005. Epub 2011 Jun 25. PMID: 21729715; PMCID: PMC3367503.
46: Gredilla R, Weissman L, Yang JL, Bohr VA, Stevnsner T. Mitochondrial base
excision repair in mouse synaptosomes during normal aging and in a model of
Alzheimer’s disease. Neurobiol Aging. 2012 Apr;33(4):694-707. doi:
10.1016/j.neurobiolaging.2010.06.019. Epub 2010 Aug 14. PMID: 20708822; PMCID:
PMC3041866.
47: Yang JL, Tadokoro T, Keijzers G, Mattson MP, Bohr VA. Neurons efficiently
repair glutamate-induced oxidative DNA damage by a process involving CREB-
mediated up-regulation of apurinic endonuclease 1. J Biol Chem. 2010 Sep
3;285(36):28191-9. doi: 10.1074/jbc.M109.082883. Epub 2010 Jun 23. PMID:
20573957; PMCID: PMC2934684.
48: Yang JL, Weissman L, Bohr VA, Mattson MP. Mitochondrial DNA damage and
repair in neurodegenerative disorders. DNA Repair (Amst). 2008 Jul
1;7(7):1110-20. doi: 10.1016/j.dnarep.2008.03.012. Epub 2008 May 7. PMID:
18463003; PMCID: PMC2442166.
研究團隊
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李姝瑩研究助理
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盧宣聿研究助理
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學術履歷
EDUCATION:
1999 – 2006 Ph.D.
Department of Biology, Neuroscience Program,
University of Texas at San Antonio, San Antonio, Texas USA
PROFESSIONAL EXPERIENCE:
2021/8 ~ present Professor
2018/8 ~ 2021/7 Associate Professor
2011/8 ~ 2018/7 Assistant Professor
Institute for Translational Research in Biomedicine,
Kaohsiung Chang Gung Memorial Hospital,
Kaohsiung, Taiwan
2007/1 ~ 2011/7 Postdoctoral Research Fellow
Laboratory of Molecular Gerontology and Laboratory of Neurosciences,
National Institute on Aging, National Institute of Health, Baltimore, Maryland USA
2006/1 ~ 2006/11 Research Scientist Associate
Department of Biology
University of Texas at San Antonio, San Antonio, Texas USA
2002/9 ~ 2005/12 Instructor of Cellular Biology Laboratory
Department of Biology
University of Texas at San Antonio, San Antonio, Texas USA
2001/9 ~ 2001/12 Instructor of Molecular Biology Laboratory
Department of Biology
University of Texas at San Antonio, San Antonio, Texas USA
2000/9 ~ 2002/5 Instructor of Laboratory Investigations in Biology
Department of Biology
University of Texas at San Antonio, San Antonio, Texas USA
1997/1 ~ 1999/8 Graduate Research Assistant
Department of Biology
University of Texas at San Antonio, San Antonio, Texas USA
AWARDS AND RESEARCH SUPPORT:
2009 Fellow Achievement Research Excellence Award, National Institute of Health
2001 Graduate Travel Award
1998 University Graduate Small Grant
1997 University Graduate Small Grant
RESEARCH INTERESTS:
1. DNA Damage and Repair in Neurons and Astrocytes
2. Roles of GLP-1 in Neurons and Glial Cells
3. Diagnosis and Therapy on Alzheimer’s Disease and Ischemic Stroke