聯絡電話
呂史提
教授
心血管疾病動物模式
幹細胞治療
基因轉殖動物模式
- 電子郵件信箱
leu@adm.cgmh.org.tw
個人簡介
Steve Leu obtained his Bachelor of Science degree from Department of Biology, National Sun Yat-Sen University, Taiwan in 1996. He went on to further his studies, working on characterization of mRNA splicing factors and generation of transgenic and knock-out mouse models, and received his PhD degree from Graduated Institute of Biomedical Sciences, Chang Gung University, Taiwan in 2005. He also received the PhD student thesis award of the Association of Anatomists of the Republic of China, scoring first place. During the postdoctoral training, he participated in generating conditional knockout mouse models to investigate the temporal and spatial-specific function of mRNA splicing factors in vivo, as well as in determining the relationship between mRNA splicing factors and apoptotic events. Besides, he also joined the cardiovascular research team in Kaohsiung Chang Gung Memorial Hospital, Taiwan, working on utilization of mesenchymal stem cell-based therapy in cardiovascular disease animal models. His research interests include disease animal models of cardiovascular disease, stem cell therapy, developmental programing of metabolic syndromes, and translational research in cardiovascular diseases.
學術著作
Recent Publications (Pubmed Search)
1: Shih WL, Yeh TM, Chen KD, Leu S, Liu SF, Huang YH, Kuo HC. Hydrogen Gas
Inhalation Treatment for Coronary Artery Lesions in a Kawasaki Disease Mouse
Model. Life (Basel). 2024 Jun 24;14(7):796. doi: 10.3390/life14070796. PMID:
39063551; PMCID: PMC11277616.
2: Chang CC, Chen CH, Hsu SY, Leu S. Cardiomyocyte-specific overexpression of
GPR22 ameliorates cardiac injury in mice with acute myocardial infarction. BMC
Cardiovasc Disord. 2024 May 30;24(1):287. doi: 10.1186/s12872-024-03953-5. PMID:
38816768; PMCID: PMC11138089.
3: Shih WL, Yeh TM, Chen KD, Leu S, Kuo HC. Positive Echocardiographic
Association between Carotid Artery and Coronary Artery Diameter and Z-Score in a
Mouse Model of Kawasaki Disease. Diagnostics (Basel). 2024 Jan 8;14(2):145. doi:
10.3390/diagnostics14020145. PMID: 38248023; PMCID: PMC10814724.
4: Lee WC, Wu KLH, Tain YL, Leu S, Cheng YT, Chan JYH. Impaired insulin
signaling at the bladder mucosa facilitates metabolic syndrome-associated
bladder overactivity in rats with maternal and post-weaning fructose exposure. J
Formos Med Assoc. 2023 Mar;122(3):258-266. doi: 10.1016/j.jfma.2022.09.013. Epub
2022 Oct 4. PMID: 36207218.
5: Hsu SY, Chen CH, Mukda S, Leu S. Neuronal Pnn Deficiency Increases Oxidative
Stress and Exacerbates Cerebral Ischemia/Reperfusion Injury in Mice.
Antioxidants (Basel). 2022 Feb 26;11(3):466. doi: 10.3390/antiox11030466. PMID:
35326115; PMCID: PMC8944488.
6: Leu S, Wu KLH, Lee WC, Tain YL, Chan JYH. Maternal Fructose Intake
Exacerbates Cardiac Remodeling in Offspring with Ventricular Pressure Overload.
Nutrients. 2021 Sep 18;13(9):3267. doi: 10.3390/nu13093267. PMID: 34579143;
PMCID: PMC8467570.
7: Leu S. The role and regulation of Pnn in proliferative and non-dividing
cells: Form embryogenesis to pathogenesis. Biochem Pharmacol. 2021
Oct;192:114672. doi: 10.1016/j.bcp.2021.114672. Epub 2021 Jul 5. PMID: 34237338.
8: Lee WC, Leu S, Wu KLH, Tain YL, Chuang YC, Chan JYH. Tadalafil ameliorates
bladder overactivity by restoring insulin-activated detrusor relaxation via the
bladder mucosal IRS/PI3K/AKT/eNOS pathway in fructose-fed rats. Sci Rep. 2021
Apr 15;11(1):8202. doi: 10.1038/s41598-021-87505-3. PMID: 33859259; PMCID:
PMC8050041.
9: Hsu SY, Mukda S, Leu S. Expression and Distribution Pattern of Pnn in
Ischemic Cerebral Cortex and Cultured Neural Cells Exposed to Oxygen-Glucose
Deprivation. Brain Sci. 2020 Oct 5;10(10):708. doi: 10.3390/brainsci10100708.
PMID: 33027948; PMCID: PMC7599571.
10: Chao YM, Wu KLH, Tsai PC, Tain YL, Leu S, Lee WC, Chan JYH. Anomalous AMPK-
regulated angiotensin AT1R expression and SIRT1-mediated
mitochondrial biogenesis at RVLM in hypertension programming of offspring to
maternal high fructose exposure. J Biomed Sci. 2020 May 23;27(1):68. doi:
10.1186/s12929-020-00660-z. PMID: 32446297; PMCID: PMC7245869.
11: Liu W, Wu CY, Lu MJ, Chuang YJ, Tsai EM, Leu S, Lin IL, Ko CJ, Chiu CC,
Chang WT. The Phenoxyphenol Compound 4-HPPP Selectively Induces
Antiproliferation Effects and Apoptosis in Human Lung Cancer Cells through
Aneupolyploidization and ATR DNA Repair Signaling. Oxid Med Cell Longev. 2020
Jan 7;2020:5167292. doi: 10.1155/2020/5167292. PMID: 32089770; PMCID:
PMC7024103.
12: Huang HL, Chou CP, Leu S, You HL, Tiao MM, Chen CH. Effects of a quasi-
experimental study of using flipped classroom approach to teach evidence-based
medicine to medical technology students. BMC Med Educ. 2020 Jan 31;20(1):31.
doi: 10.1186/s12909-020-1946-7. PMID: 32005227; PMCID: PMC6995213.
13: Chen CH, Hsu SY, Chiu CC, Leu S. MicroRNA-21 Mediates the Protective Effect
of Cardiomyocyte-Derived Conditioned Medium on Ameliorating Myocardial
Infarction in Rats. Cells. 2019 Aug 19;8(8):935. doi: 10.3390/cells8080935.
PMID: 31430983; PMCID: PMC6721717.
14: Mukda S, Tsai CY, Leu S, Yang JL, Chan SHH. Pinin protects astrocytes from
cell death after acute ischemic stroke via maintenance of mitochondrial anti-
apoptotic and bioenergetics functions. J Biomed Sci. 2019 Jun 5;26(1):43. doi:
10.1186/s12929-019-0538-5. PMID: 31167655; PMCID: PMC6549339.
15: Leu S, Wu KLH, Lee WC, Tain YL, Chan JYH. The Impact of Maternal Fructose
Exposure on Angiogenic Activity of Endothelial Progenitor Cells and Blood Flow
Recovery After Critical Limb Ischemia in Rat Offspring. Int J Mol Sci. 2019 May
16;20(10):2429. doi: 10.3390/ijms20102429. PMID: 31100865; PMCID: PMC6566409.
16: Wu CW, Hung CY, Hirase H, Tain YL, Lee WC, Chan JYH, Fu MH, Chen LW, Liu WC,
Liang CK, Ho YH, Kung YC, Leu S, Wu KLH. Pioglitazone reversed the fructose-
programmed astrocytic glycolysis and oxidative phosphorylation of female rat
offspring. Am J Physiol Endocrinol Metab. 2019 Apr 1;316(4):E622-E634. doi:
10.1152/ajpendo.00408.2018. Epub 2019 Jan 22. PMID: 30668149.
17: Lee WC, Wu KLH, Leu S, Tain YL. Translational insights on developmental
origins of metabolic syndrome: Focus on fructose consumption. Biomed J. 2018
Apr;41(2):96-101. doi: 10.1016/j.bj.2018.02.006. PMID: 29866605; PMCID:
PMC6138777.
18: Tain YL, Lee WC, Wu KLH, Leu S, Chan JYH. Resveratrol Prevents the
Development of Hypertension Programmed by Maternal Plus Post-Weaning High-
Fructose Consumption through Modulation of Oxidative Stress, Nutrient-Sensing
Signals, and Gut Microbiota. Mol Nutr Food Res. 2018 Aug;62(15):e1800066. doi:
10.1002/mnfr.201800066. Epub 2018 Jul 12. PMID: 29710384.
19: Tain YL, Leu S, Lee WC, Wu KLH, Chan JYH. Maternal Melatonin Therapy
Attenuated Maternal High-Fructose Combined with Post-Weaning High-Salt Diets-
Induced Hypertension in Adult Male Rat Offspring. Molecules. 2018 Apr
11;23(4):886. doi: 10.3390/molecules23040886. PMID: 29641494; PMCID: PMC6017187.
20: Tain YL, Wu KLH, Lee WC, Leu S, Chan JYH. Prenatal Metformin Therapy
Attenuates Hypertension of Developmental Origin in Male Adult Offspring Exposed
to Maternal High-Fructose and Post-Weaning High-Fat Diets. Int J Mol Sci. 2018
Apr 3;19(4):1066. doi: 10.3390/ijms19041066. PMID: 29614026; PMCID: PMC5979307.
21: Tain YL, Lee WC, Wu KLH, Leu S, Chan JYH. Maternal High Fructose Intake
Increases the Vulnerability to Post-Weaning High-Fat Diet-Induced Programmed
Hypertension in Male Offspring. Nutrients. 2018 Jan 9;10(1):56. doi:
10.3390/nu10010056. PMID: 29315230; PMCID: PMC5793284.
22: Chou CK, Chang YT, Korinek M, Chen YT, Yang YT, Leu S, Lin IL, Tang CJ, Chiu
CC. Correction: Chon-Kit Chou, et al. The Regulations of Deubiquitinase USP15
and Its Pathophysiological Mechanisms in Diseases. Int. J. Mol. Sci. 2017, 18,
483. Int J Mol Sci. 2017 Apr 25;18(5):902. doi: 10.3390/ijms18050902. Erratum
for: Int J Mol Sci. 2017 Feb 24;18(3):E483. doi: 10.3390/ijms18030483. PMID:
28441349; PMCID: PMC5454815.
23: Chou CK, Chang YT, Korinek M, Chen YT, Yang YT, Leu S, Lin IL, Tang CJ, Chiu
CC. The Regulations of Deubiquitinase USP15 and Its Pathophysiological
Mechanisms in Diseases. Int J Mol Sci. 2017 Feb 24;18(3):483. doi:
10.3390/ijms18030483. Erratum in: Int J Mol Sci. 2017 Apr 25;18(5):E902. doi:
10.3390/ijms18050902. PMID: 28245560; PMCID: PMC5372499.
24: Tseng CC, Wang CC, Hsiao CC, Lu HI, Leu S, Chang HC, Huang KT, Fang WF, Chen
YM, Liu SF, Yang CT, Lin MC, Yip HK. Time courses and value of circulating
microparticles in patients with operable stage non-small cell lung cancer
undergoing surgical intervention. Tumour Biol. 2016 Sep;37(9):11873-11882. doi:
10.1007/s13277-016-5047-5. Epub 2016 Apr 8. PMID: 27059732.
25: Chao YM, Tain YL, Leu S, Wu KL, Lee WC, Chan JY. Developmental programming
of the metabolic syndrome: Next-generation sequencing analysis of transcriptome
expression in a rat model of maternal high fructose intake. Sheng Li Xue Bao.
2016 Oct 25;68(5):557-567. PMID: 27778020.
26: Tain YL, Lee WC, Wu KLH, Leu S, Chan JYH. Targeting arachidonic acid pathway
to prevent programmed hypertension in maternal fructose-fed male adult rat
offspring. J Nutr Biochem. 2016 Dec;38:86-92. doi:
10.1016/j.jnutbio.2016.08.006. Epub 2016 Sep 7. PMID: 27732913.
27: Lee WC, Tain YL, Wu KL, Leu S, Chan JY. Maternal Fructose Exposure Programs
Metabolic Syndrome-Associated Bladder Overactivity in Young Adult Offspring. Sci
Rep. 2016 Oct 5;6:34669. doi: 10.1038/srep34669. PMID: 27703194; PMCID:
PMC5050417.
28: Leu S, Day YJ, Sun CK, Yip HK. tPA-MMP-9 Axis Plays a Pivotal Role in
Mobilization of Endothelial Progenitor Cells from Bone Marrow to Circulation and
Ischemic Region for Angiogenesis. Stem Cells Int. 2016;2016:5417565. doi:
10.1155/2016/5417565. Epub 2016 Aug 16. PMID: 27610138; PMCID: PMC5004042.
29: Hsu CN, Wu KL, Lee WC, Leu S, Chan JY, Tain YL. Aliskiren Administration
during Early Postnatal Life Sex-Specifically Alleviates Hypertension Programmed
by Maternal High Fructose Consumption. Front Physiol. 2016 Jul 12;7:299. doi:
10.3389/fphys.2016.00299. PMID: 27462279; PMCID: PMC4941125.
30: Chai HT, Yip HK, Sun CK, Hsu SY, Leu S. AG490 suppresses EPO-mediated
activation of JAK2-STAT but enhances blood flow recovery in rats with critical
limb ischemia. J Inflamm (Lond). 2016 Jun 4;13:18. doi:
10.1186/s12950-016-0126-3. PMID: 27274711; PMCID: PMC4893245.
31: Shao PL, Liao JD, Wong TW, Wang YC, Leu S, Yip HK. Enhancement of Wound
Healing by Non-Thermal N2/Ar Micro-Plasma Exposure in Mice with Fractional-
CO2-Laser-Induced Wounds. PLoS One. 2016 Jun 1;11(6):e0156699. doi:
10.1371/journal.pone.0156699. PMID: 27248979; PMCID: PMC4889145.
32: Ko SF, Yip HK, Zhen YY, Lee CC, Li JH, Lee CC, Leu S, Huang CC, Ng SH, Lin
JW. Cancer Patient-Derived Circulating Microparticles Enhance Lung Metastasis in
a Rat Model: Dual-Source CT, Cellular, and Molecular Studies. Mol Imaging Biol.
2016 Aug;18(4):490-9. doi: 10.1007/s11307-015-0923-8. PMID: 26669780.
33: Chen YL, Sun CK, Tsai TH, Chang LT, Leu S, Zhen YY, Sheu JJ, Chua S, Yeh KH,
Lu HI, Chang HW, Lee FY, Yip HK. Adipose-derived mesenchymal stem cells embedded
in platelet-rich fibrin scaffolds promote angiogenesis, preserve heart function,
and reduce left ventricular remodeling in rat acute myocardial infarction. Am J
Transl Res. 2015 May 15;7(5):781-803. PMID: 26175843; PMCID: PMC4494133.
34: Lee FY, Chen YL, Sung PH, Ma MC, Pei SN, Wu CJ, Yang CH, Fu M, Ko SF, Leu S,
Yip HK. Intracoronary Transfusion of Circulation-Derived CD34+ Cells Improves
Left Ventricular Function in Patients With End-Stage Diffuse Coronary Artery
Disease Unsuitable for Coronary Intervention. Crit Care Med. 2015
Oct;43(10):2117-32. doi: 10.1097/CCM.0000000000001138. PMID: 26154930.
35: Sun CK, Leu S, Hsu SY, Zhen YY, Chang LT, Tsai CY, Chen YL, Chen YT, Tsai
TH, Lee FY, Sheu JJ, Chang HW, Yip HK. Mixed serum-deprived and normal adipose-
derived mesenchymal stem cells against acute lung ischemia-reperfusion injury in
rats. Am J Transl Res. 2015 Feb 15;7(2):209-31. PMID: 25901192; PMCID:
PMC4399087.
36: Sheu JJ, Lee FY, Wallace CG, Tsai TH, Leu S, Chen YL, Chai HT, Lu HI, Sun
CK, Yip HK. Administered circulating microparticles derived from lung cancer
patients markedly improved angiogenesis, blood flow and ischemic recovery in rat
critical limb ischemia. J Transl Med. 2015 Feb 15;13:59. doi:
10.1186/s12967-015-0381-8. PMID: 25889721; PMCID: PMC4369091.
37: Tsai CY, Su CH, Leu S, Chang AY, Chan JY, Chan SH. Endogenous vascular
endothelial growth factor produces tonic facilitation of cardiac vagal
baroreflex via fetal liver kinase-1 in medulla oblongata. Int J Cardiol.
2015;187:421-5. doi: 10.1016/j.ijcard.2015.03.375. Epub 2015 Mar 27. PMID:
25841140.
38: Tain YL, Wu KL, Lee WC, Leu S, Chan JY. Maternal fructose-intake-induced
renal programming in adult male offspring. J Nutr Biochem. 2015
Jun;26(6):642-50. doi: 10.1016/j.jnutbio.2014.12.017. Epub 2015 Feb 26. PMID:
25765514.
39: Tsai TH, Sun CK, Su CH, Sung PH, Chua S, Zhen YY, Leu S, Chang HW, Yang JL,
Yip HK. Sitagliptin attenuated brain damage and cognitive impairment in mice
with chronic cerebral hypo-perfusion through suppressing oxidative stress and
inflammatory reaction. J Hypertens. 2015 May;33(5):1001-13. doi:
10.1097/HJH.0000000000000529. PMID: 25689400.
40: Chang MW, Chen CH, Chen YC, Wu YC, Zhen YY, Leu S, Tsai TH, Ko SF, Sung PH,
Yang CC, Chiang HJ, Chang HW, Chen YT, Yip HK. Sitagliptin protects rat kidneys
from acute ischemia-reperfusion injury via upregulation of GLP-1 and GLP-1
receptors. Acta Pharmacol Sin. 2015 Jan;36(1):119-30. doi: 10.1038/aps.2014.98.
Epub 2014 Dec 15. PMID: 25500876; PMCID: PMC4571325.
41: Chua S, Lee FY, Tsai TH, Sheu JJ, Leu S, Sun CK, Chen YL, Chang HW, Chai HT,
Liu CF, Lu HI, Yip HK. Inhibition of dipeptidyl peptidase-IV enzyme activity
protects against myocardial ischemia-reperfusion injury in rats. J Transl Med.
2014 Dec 13;12:357. doi: 10.1186/s12967-014-0357-0. PMID: 25496837; PMCID:
PMC4301397.
42: Sun CK, Lee FY, Kao YH, Chiang HJ, Sung PH, Tsai TH, Lin YC, Leu S, Wu YC,
Lu HI, Chen YL, Chung SY, Su HL, Yip HK. Systemic combined melatonin-
mitochondria treatment improves acute respiratory distress syndrome in the rat.
J Pineal Res. 2015 Mar;58(2):137-50. doi: 10.1111/jpi.12199. Epub 2014 Dec 27.
PMID: 25491480.
43: Tsai CY, Chua S, Leu S, Chang AY, Chan JY, Chan SH. VEGF tonically sustains
myocardial performance via fetal liver kinase-1 in the heart. Int J Cardiol.
2014 Dec 15;177(2):727-30. doi: 10.1016/j.ijcard.2014.10.019. PMID: 25456694.
44: Chen HH, Chang CL, Lin KC, Sung PH, Chai HT, Zhen YY, Chen YC, Wu YC, Leu S,
Tsai TH, Chen CH, Chang HW, Yip HK. Melatonin augments apoptotic adipose-derived
mesenchymal stem cell treatment against sepsis-induced acute lung injury. Am J
Transl Res. 2014 Oct 11;6(5):439-58. PMID: 25360211; PMCID: PMC4212921.
45: Chen YT, Chiang HJ, Chen CH, Sung PH, Lee FY, Tsai TH, Chang CL, Chen HH,
Sun CK, Leu S, Chang HW, Yang CC, Yip HK. Melatonin treatment further improves
adipose-derived mesenchymal stem cell therapy for acute interstitial cystitis in
rat. J Pineal Res. 2014 Oct;57(3):248-61. doi: 10.1111/jpi.12164. Epub 2014 Aug
27. PMID: 25132326.
46: Ko SF, Yip HK, Leu S, Lee CC, Sheu JJ, Lee CC, Ng SH, Huang CC, Chen MC, Sun
CK. Therapeutic potential of tacrolimus on acute myocardial infarction in
minipigs: analysis with serial cardiac magnetic resonance and changes at
histological and protein levels. Biomed Res Int. 2014;2014:524078. doi:
10.1155/2014/524078. Epub 2014 Jul 9. PMID: 25114905; PMCID: PMC4119637.
47: Wang CC, Tseng CC, Hsiao CC, Chang HC, Chang LT, Fang WF, Leu S, Wang YH,
Tsai TH, Yang CT, Chen CH, Yip HK, Ho CK, Lin MC. Circulating endothelial-
derived activated microparticle: a useful biomarker for predicting one-year
mortality in patients with advanced non-small cell lung cancer. Biomed Res Int.
2014;2014:173401. doi: 10.1155/2014/173401. Epub 2014 Jun 29. PMID: 25061601;
PMCID: PMC4100353.
48: Fan CQ, Leu S, Sheu JJ, Zhen YY, Tsai TH, Chen YL, Chung SY, Chai HT, Sun
CK, Yang JL, Chang HW, Ko SF, Yip HK. Prompt bone marrow-derived mesenchymal
stem cell therapy enables early porcine heart function recovery from acute
myocardial infarction. Int Heart J. 2014;55(4):362-71. doi: 10.1536/ihj.14-007.
Epub 2014 Jun 25. PMID: 24965596.
49: Tain YL, Leu S, Wu KL, Lee WC, Chan JY. Melatonin prevents maternal fructose
intake-induced programmed hypertension in the offspring: roles of nitric oxide
and arachidonic acid metabolites. J Pineal Res. 2014 Aug;57(1):80-9. doi:
10.1111/jpi.12145. Epub 2014 Jun 16. PMID: 24867192.
50: Chen HH, Lin KC, Wallace CG, Chen YT, Yang CC, Leu S, Chen YC, Sun CK, Tsai
TH, Chen YL, Chung SY, Chang CL, Yip HK. Additional benefit of combined therapy
with melatonin and apoptotic adipose-derived mesenchymal stem cell against
sepsis-induced kidney injury. J Pineal Res. 2014 Aug;57(1):16-32. doi:
10.1111/jpi.12140. Epub 2014 May 15. PMID: 24761983.
51: Sheu JJ, Lin PY, Sung PH, Chen YC, Leu S, Chen YL, Tsai TH, Chai HT, Chua S,
Chang HW, Chung SY, Chen CH, Ko SF, Yip HK. Levels and values of lipoprotein-
associated phospholipase A2, galectin-3, RhoA/ROCK, and endothelial progenitor
cells in critical limb ischemia: pharmaco-therapeutic role of cilostazol and
clopidogrel combination therapy. J Transl Med. 2014 Apr 17;12:101. doi:
10.1186/1479-5876-12-101. PMID: 24742198; PMCID: PMC4234320.
52: Sun CK, Zhen YY, Leu S, Tsai TH, Chang LT, Sheu JJ, Chen YL, Chua S, Chai
HT, Lu HI, Chang HW, Lee FY, Yip HK. Direct implantation versus platelet-rich
fibrin-embedded adipose-derived mesenchymal stem cells in treating rat acute
myocardial infarction. Int J Cardiol. 2014 May 15;173(3):410-23. doi:
10.1016/j.ijcard.2014.03.015. Epub 2014 Mar 14. PMID: 24685001.
53: Sung PH, Chang CL, Tsai TH, Chang LT, Leu S, Chen YL, Yang CC, Chua S, Yeh
KH, Chai HT, Chang HW, Chen HH, Yip HK. Apoptotic adipose-derived mesenchymal
stem cell therapy protects against lung and kidney injury in sepsis syndrome
caused by cecal ligation puncture in rats. Stem Cell Res Ther. 2013;4(6):155.
doi: 10.1186/scrt385. PMID: 24451364; PMCID: PMC4054966.
54: Leu S, Lu HI, Sun CK, Sheu JJ, Chen YL, Tsai TH, Yeh KH, Chai HT, Chua S,
Tsai CY, Chang HW, Lee FY, Yip HK. Retention of endothelial progenitor cells in
bone marrow in a murine model of endogenous tissue plasminogen activator (tPA)
deficiency in response to critical limb ischemia. Int J Cardiol. 2014 Jan
1;170(3):394-405. doi: 10.1016/j.ijcard.2013.11.021. Epub 2013 Nov 12. PMID:
24290069.
55: Tseng CC, Wang CC, Chang HC, Tsai TH, Chang LT, Huang KT, Leu S, Yen CH, Liu
SF, Chen CH, Yang CT, Yip HK, Lin MC. Levels of circulating microparticles in
lung cancer patients and possible prognostic value. Dis Markers.
2013;35(5):301-10. doi: 10.1155/2013/715472. Epub 2013 Sep 15. PMID: 24167378;
PMCID: PMC3787568.
56: Sheu JJ, Sung PH, Leu S, Chai HT, Zhen YY, Chen YC, Chua S, Chen YL, Tsai
TH, Lee FY, Chang HW, Ko SF, Yip HK. Innate immune response after acute
myocardial infarction and pharmacomodulatory action of tacrolimus in reducing
infarct size and preserving myocardial integrity. J Biomed Sci. 2013 Oct
29;20(1):82. doi: 10.1186/1423-0127-20-82. PMID: 24165293; PMCID: PMC4174893.
57: Chen YT, Tsai TH, Yang CC, Sun CK, Chang LT, Chen HH, Chang CL, Sung PH,
Zhen YY, Leu S, Chang HW, Chen YL, Yip HK. Exendin-4 and sitagliptin protect
kidney from ischemia-reperfusion injury through suppressing oxidative stress and
inflammatory reaction. J Transl Med. 2013 Oct 25;11:270. doi:
10.1186/1479-5876-11-270. PMID: 24161164; PMCID: PMC4231365.
58: Lee FY, Lu HI, Zhen YY, Leu S, Chen YL, Tsai TH, Chung SY, Chua S, Sheu JJ,
Hsu SY, Chang HW, Sun CK, Yip HK. Benefit of combined therapy with nicorandil
and colchicine in preventing monocrotaline-induced rat pulmonary arterial
hypertension. Eur J Pharm Sci. 2013 Nov 20;50(3-4):372-84. doi:
10.1016/j.ejps.2013.08.004. Epub 2013 Aug 15. PMID: 23954457.
59: Chua S, Sheu JJ, Chen YL, Chang LT, Sun CK, Leu S, Sung HC, Tsai TH, Chung
SY, Yeh KH, Cho CL, Kao YH, Yip HK. Sitagliptin therapy enhances the number of
circulating angiogenic cells and angiogenesis-evaluations in vitro and in the
rat critical limb ischemia model. Cytotherapy. 2013 Sep;15(9):1148-63. doi:
10.1016/j.jcyt.2013.05.005. Epub 2013 Jul 10. PMID: 23849976.
60: Chen YT, Yang CC, Zhen YY, Wallace CG, Yang JL, Sun CK, Tsai TH, Sheu JJ,
Chua S, Chang CL, Cho CL, Leu S, Yip HK. Cyclosporine-assisted adipose-derived
mesenchymal stem cell therapy to mitigate acute kidney ischemia-reperfusion
injury. Stem Cell Res Ther. 2013 May 31;4(3):62. doi: 10.1186/scrt212. PMID:
23726287; PMCID: PMC3706768.
61: Lin YC, Chiang CH, Chang LT, Sun CK, Leu S, Shao PL, Hsieh MC, Tsai TH, Chua
S, Chung SY, Kao YH, Yip HK. Simvastatin attenuates the additive effects of
TNF-α and IL-18 on the connexin 43 up-regulation and over-proliferation of
cultured aortic smooth muscle cells. Cytokine. 2013 Jun;62(3):341-51. doi:
10.1016/j.cyto.2013.04.003. Epub 2013 Apr 22. PMID: 23618917.
62: Sun CK, Leu S, Sheu JJ, Tsai TH, Sung HC, Chen YL, Chung SY, Ko SF, Chang
HW, Yip HK. Paradoxical impairment of angiogenesis, endothelial function and
circulating number of endothelial progenitor cells in DPP4-deficient rat after
critical limb ischemia. Stem Cell Res Ther. 2013 Mar 21;4(2):31. doi:
10.1186/scrt181. PMID: 23517567; PMCID: PMC3706813.
63: Lin YJ, Chung SY, Liang CD, Kuo HC, Huang CF, Chien SJ, Lin IC, Leu S, Sun
CK, Ko SF, Sheu JJ, Yip HK. Impact of extracorporeal membrane oxygenation
support on clinical outcome of pediatric patients with acute cardiopulmonary
failure: a single-center experience. Biomed J. 2013 Jan-Feb;36(1):28-34. doi:
10.4103/2319-4170.107161. PMID: 23515152.
64: Yen CH, Tsai TH, Leu S, Chen YL, Chang LT, Chai HT, Chung SY, Chua S, Tsai
CY, Chang HW, Ko SF, Sun CK, Yip HK. Sildenafil improves long-term effect of
endothelial progenitor cell-based treatment for monocrotaline-induced rat
pulmonary arterial hypertension. Cytotherapy. 2013 Feb;15(2):209-23. doi:
10.1016/j.jcyt.2012.09.002. Epub 2012 Dec 11. PMID: 23321332.
65: Chen CH, Chuang HC, Huang CC, Fang FM, Huang HY, Tsai HT, Su LJ, Shiu LY,
Leu S, Chien CY. Overexpression of Rap-1A indicates a poor prognosis for oral
cavity squamous cell carcinoma and promotes tumor cell invasion via Aurora-A
modulation. Am J Pathol. 2013 Feb;182(2):516-28. doi:
10.1016/j.ajpath.2012.10.023. Epub 2012 Dec 3. PMID: 23219753.
66: Chang CL, Leu S, Sung HC, Zhen YY, Cho CL, Chen A, Tsai TH, Chung SY, Chai
HT, Sun CK, Yen CH, Yip HK. Impact of apoptotic adipose-derived mesenchymal stem
cells on attenuating organ damage and reducing mortality in rat sepsis syndrome
induced by cecal puncture and ligation. J Transl Med. 2012 Dec 7;10:244. doi:
10.1186/1479-5876-10-244. PMID: 23217183; PMCID: PMC3543276.
67: Yip HK, Chang YC, Wallace CG, Chang LT, Tsai TH, Chen YL, Chang HW, Leu S,
Zhen YY, Tsai CY, Yeh KH, Sun CK, Yen CH. Melatonin treatment improves adipose-
derived mesenchymal stem cell therapy for acute lung ischemia-reperfusion
injury. J Pineal Res. 2013 Mar;54(2):207-21. doi: 10.1111/jpi.12020. Epub 2012
Oct 30. PMID: 23110436.
68: Yip HK, Sun CK, Tsai TH, Sheu JJ, Kao YH, Lin YC, Shiue YL, Chen YL, Chai
HT, Chua S, Ko SF, Leu S. Tissue plasminogen activator enhances mobilization of
endothelial progenitor cells and angiogenesis in murine limb ischemia. Int J
Cardiol. 2013 Sep 20;168(1):226-36. doi: 10.1016/j.ijcard.2012.09.090. Epub 2012
Oct 9. PMID: 23063135.
69: Yang CH, Sheu JJ, Tsai TH, Chua S, Chang LT, Chang HW, Lee FY, Chen YL,
Chung SY, Sun CK, Leu S, Yen CH, Yip HK. Effect of tacrolimus on myocardial
infarction is associated with inflammation, ROS, MAP kinase and Akt pathways in
mini-pigs. J Atheroscler Thromb. 2013;20(1):9-22. doi: 10.5551/jat.14316. Epub
2012 Aug 16. PMID: 22972310.
70: Sheu JJ, Lin KC, Tsai CY, Tsai TH, Leu S, Yen CH, Chen YL, Chang HW, Sun CK,
Chua S, Yang JL, Yip HK. Combination of cilostazol and clopidogrel attenuates
rat critical limb ischemia. J Transl Med. 2012 Aug 16;10:164. doi:
10.1186/1479-5876-10-164. PMID: 22897925; PMCID: PMC3479044.
71: Chen YT, Cheng BC, Ko SF, Chen CH, Tsai TH, Leu S, Chang HW, Chung SY, Chua
S, Yeh KH, Chen YL, Yip HK. Value and level of circulating endothelial
progenitor cells, angiogenesis factors and mononuclear cell apoptosis in
patients with chronic kidney disease. Clin Exp Nephrol. 2013 Feb;17(1):83-91.
doi: 10.1007/s10157-012-0664-9. Epub 2012 Jul 20. PMID: 22814956.
72: Yen CH, Sun CK, Leu S, Wallace CG, Lin YC, Chang LT, Chen YL, Tsa TH, Kao
YH, Shao PL, Hsieh CY, Chen YT, Yip HK. Continuing exposure to low-dose
nonylphenol aggravates adenine-induced chronic renal dysfunction and role of
rosuvastatin therapy. J Transl Med. 2012 Jul 19;10:147. doi:
10.1186/1479-5876-10-147. PMID: 22812704; PMCID: PMC3543300.
73: Chen CH, Chang LT, Tung WC, Chen YL, Chang CL, Leu S, Sun CK, Tsai TH, Tsai
IT, Chang HW, Yip HK. Levels and values of circulating endothelial progenitor
cells, soluble angiogenic factors, and mononuclear cell apoptosis in liver
cirrhosis patients. J Biomed Sci. 2012 Jul 18;19(1):66. doi:
10.1186/1423-0127-19-66. PMID: 22809449; PMCID: PMC3414826.
74: Wang HT, Liu CF, Tsai TH, Chen YL, Chang HW, Tsai CY, Leu S, Zhen YY, Chai
HT, Chung SY, Chua S, Yen CH, Yip HK. Effect of obesity reduction on
preservation of heart function and attenuation of left ventricular remodeling,
oxidative stress and inflammation in obese mice. J Transl Med. 2012 Jul
11;10:145. doi: 10.1186/1479-5876-10-145. PMID: 22784636; PMCID: PMC3551744.
75: Tsai TH, Chai HT, Sun CK, Yen CH, Leu S, Chen YL, Chung SY, Ko SF, Chang HW,
Wu CJ, Yip HK. Obesity suppresses circulating level and function of endothelial
progenitor cells and heart function. J Transl Med. 2012 Jul 2;10:137. doi:
10.1186/1479-5876-10-137. PMID: 22747715; PMCID: PMC3543390.
76: Chua S, Leu S, Sheu JJ, Lin YC, Chang LT, Kao YH, Yen CH, Tsai TH, Chen YL,
Chang HW, Sun CK, Yip HK. Intra-coronary administration of tacrolimus markedly
attenuates infarct size and preserves heart function in porcine myocardial
infarction. J Inflamm (Lond). 2012 Jun 1;9(1):21. doi: 10.1186/1476-9255-9-21.
PMID: 22658082; PMCID: PMC3408362.
77: Chen YL, Chang CL, Sun CK, Wu CJ, Tsai TH, Chung SY, Chua S, Yeh KH, Leu S,
Sheu JJ, Lee FY, Yen CH, Yip HK. Impact of obesity control on circulating level
of endothelial progenitor cells and angiogenesis in response to ischemic
stimulation. J Transl Med. 2012 Jul 11;10:86. doi: 10.1186/1479-5876-10-86.
PMID: 22568992; PMCID: PMC3394222.
78: Yen CH, Lin KC, Leu S, Sun CK, Chang LT, Chai HT, Chung SY, Chang HW, Ko SF,
Chen YT, Yip HK. Chronic exposure to environmental contaminant nonylphenol
exacerbates adenine-induced chronic renal insufficiency: role of signaling
pathways and therapeutic impact of rosuvastatin. Eur J Pharm Sci. 2012 Aug
15;46(5):455-67. doi: 10.1016/j.ejps.2012.03.009. Epub 2012 Mar 29. PMID:
22484332.
79: Leu S, Lin YM, Wu CH, Ouyang P. Loss of Pnn expression results in mouse
early embryonic lethality and cellular apoptosis through SRSF1-mediated
alternative expression of Bcl-xS and ICAD. J Cell Sci. 2012 Jul 1;125(Pt
13):3164-72. doi: 10.1242/jcs.100859. Epub 2012 Mar 27. PMID: 22454513.
80: Tsai TH, Chen YL, Lin HS, Liu CF, Chang HW, Lu CH, Chang WN, Chen SF, Wu CJ,
Leu S, Ko SF, Yip HK. Link between lipoprotein-associated phospholipase A2 gene
expression of peripheral-blood mononuclear cells and prognostic outcome after
acute ischemic stroke. J Atheroscler Thromb. 2012;19(6):523-31. doi:
10.5551/jat.10751. Epub 2012 Mar 17. PMID: 22447189.
81: Chung SY, Sheu JJ, Lin YJ, Sun CK, Chang LT, Chen YL, Tsai TH, Chen CJ, Yang
CH, Hang CL, Leu S, Wu CJ, Lee FY, Yip HK. Outcome of patients with profound
cardiogenic shock after cardiopulmonary resuscitation and prompt extracorporeal
membrane oxygenation support. A single-center observational study. Circ J.
2012;76(6):1385-92. doi: 10.1253/circj.cj-11-1015. Epub 2012 Mar 13. PMID:
22447007.
82: Sun CK, Chang CL, Lin YC, Kao YH, Chang LT, Yen CH, Shao PL, Chen CH, Leu S,
Yip HK. Systemic administration of autologous adipose-derived mesenchymal stem
cells alleviates hepatic ischemia-reperfusion injury in rats. Crit Care Med.
2012 Apr;40(4):1279-90. doi: 10.1097/CCM.0b013e31823dae23. PMID: 22336724.
83: Yeh KH, Tsai TH, Chai HT, Leu S, Chung SY, Chua S, Chen YL, Lin HS, Yuen CM,
Yip HK. Comparison of acute versus convalescent stage high-sensitivity
C-Reactive protein level in predicting clinical outcome after acute ischemic
stroke and impact of erythropoietin. J Transl Med. 2012 Jan 5;10:6. doi:
10.1186/1479-5876-10-6. PMID: 22222005; PMCID: PMC3286363.
84: Yeh KH, Sheu JJ, Lin YC, Sun CK, Chang LT, Kao YH, Yen CH, Shao PL, Tsai TH,
Chen YL, Chua S, Leu S, Yip HK. Benefit of combined extracorporeal shock wave
and bone marrow-derived endothelial progenitor cells in protection against
critical limb ischemia in rats. Crit Care Med. 2012 Jan;40(1):169-77. doi:
10.1097/CCM.0b013e31822d74d0. PMID: 21926605.
85: Fu M, Sun CK, Lin YC, Wang CJ, Wu CJ, Ko SF, Chua S, Sheu JJ, Chiang CH,
Shao PL, Leu S, Yip HK. Extracorporeal shock wave therapy reverses ischemia-
related left ventricular dysfunction and remodeling: molecular-cellular and
functional assessment. PLoS One. 2011;6(9):e24342. doi:
10.1371/journal.pone.0024342. Epub 2011 Sep 6. PMID: 21915315; PMCID:
PMC3167851.
86: Yuen CM, Sun CK, Lin YC, Chang LT, Kao YH, Yen CH, Chen YL, Tsai TH, Chua S,
Shao PL, Leu S, Yip HK. Combination of cyclosporine and erythropoietin improves
brain infarct size and neurological function in rats after ischemic stroke. J
Transl Med. 2011 Aug 24;9:141. doi: 10.1186/1479-5876-9-141. PMID: 21864394;
PMCID: PMC3177906.
87: Sun CK, Yen CH, Lin YC, Tsai TH, Chang LT, Kao YH, Chua S, Fu M, Ko SF, Leu
S, Yip HK. Autologous transplantation of adipose-derived mesenchymal stem cells
markedly reduced acute ischemia-reperfusion lung injury in a rodent model. J
Transl Med. 2011 Jul 22;9:118. doi: 10.1186/1479-5876-9-118. PMID: 21781312;
PMCID: PMC3155151.
88: Lin CJ, Liu CF, Kung CT, Sun CK, Lin YC, Leu S, Chua S, Yeh KH, Wu CJ, Chen
YL, Yip HK. The prognostic value of atrial fibrillation on 30-day clinical
outcome in patients with ST-segment elevation myocardial infarction undergoing
primary percutaneous coronary intervention. Int Heart J. 2011;52(3):153-8. doi:
10.1536/ihj.52.153. PMID: 21646737.
89: Sun CK, Lin YC, Yuen CM, Chua S, Chang LT, Sheu JJ, Lee FY, Fu M, Leu S, Yip
HK. Enhanced protection against pulmonary hypertension with sildenafil and
endothelial progenitor cell in rats. Int J Cardiol. 2012 Dec 15;162(1):45-58.
doi: 10.1016/j.ijcard.2011.05.002. Epub 2011 May 28. PMID: 21620490.
90: Yuen CM, Sun CK, Leu S, Yip HK. Effect of erythropoietin therapy on clinical
outcome in patients after acute ischemic stroke: a debatable issue. Crit Care.
2011;15(3):425. doi: 10.1186/cc10145. Epub 2011 May 17. PMID: 21586100; PMCID:
PMC3218967.
91: Chen YT, Sun CK, Lin YC, Chang LT, Chen YL, Tsai TH, Chung SY, Chua S, Kao
YH, Yen CH, Shao PL, Chang KC, Leu S, Yip HK. Adipose-derived mesenchymal stem
cell protects kidneys against ischemia-reperfusion injury through suppressing
oxidative stress and inflammatory reaction. J Transl Med. 2011 May 5;9:51. doi:
10.1186/1479-5876-9-51. PMID: 21545725; PMCID: PMC3112438.
92: Yip HK, Tsai TH, Lin HS, Chen SF, Sun CK, Leu S, Yuen CM, Tan TY, Lan MY,
Liou CW, Lu CH, Chang WN. Effect of erythropoietin on level of circulating
endothelial progenitor cells and outcome in patients after acute ischemic
stroke. Crit Care. 2011;15(1):R40. doi: 10.1186/cc10002. Epub 2011 Jan 26. PMID:
21269484; PMCID: PMC3221969.
93: Leu S, Kao YH, Sun CK, Lin YC, Tsai TH, Chang LT, Chua S, Yeh KH, Wu CJ, Fu
M, Yip HK. Myocardium-derived conditioned medium improves left ventricular
function in rodent acute myocardial infarction. J Transl Med. 2011 Jan 18;9:11.
doi: 10.1186/1479-5876-9-11. PMID: 21244680; PMCID: PMC3033820.
94: Tsai TH, Chua S, Hussein H, Leu S, Wu CJ, Hang CL, Fang HY, Chung SY, Fu M,
Chen HC, Chang LT, Yeh KH, Yip HK. Outcomes of patients with Killip class III
acute myocardial infarction after primary percutaneous coronary intervention.
Crit Care Med. 2011 Mar;39(3):436-42. doi: 10.1097/CCM.0b013e318206ccc3. Erratum
in: Crit Care Med. 2011 May;39(5):1247. PMID: 21242801.
95: Chua S, Leu S, Lin YC, Sheu JJ, Sun CK, Chung SY, Chai HT, Lee FY, Kao YH,
Wu CJ, Chang LT, Ko SF, Yip HK. Early erythropoietin therapy attenuates
remodeling and preserves function of left ventricle in porcine myocardial
infarction. J Investig Med. 2011 Mar;59(3):574-86. doi:
10.2310/JIM.0b013e31820877dc. PMID: 21200333.
96: Tsai TH, Lin YC, Sun CK, Chung SY, Chai HT, Yang CH, Chen SM, Hang CL, Chen
CJ, Chua S, Wu CJ, Leu S, Yip HK. Prognostic value of circulating dead monocytes
in patients with acute st-elevation myocardial infarction undergoing primary
percutaneous coronary intervention. Cardiology. 2010;117(2):131-9. doi:
10.1159/000320208. Epub 2010 Oct 22. PMID: 20975265.
97: Tsai TH, Sun CK, Chung WJ, Lin YC, Leu S, Hussein H, Chen YL, Chung SY, Chai
HT, Chua S, Fu M, Yip HK. Prognostic value of R-wave voltage in patients with
anterior wall ST-segment elevation myocardial infarction undergoing primary
percutaneous coronary intervention. Int Heart J. 2010;51(5):325-30. doi:
10.1536/ihj.51.325. PMID: 20966604.
98: Chen HC, Tsai TH, Fang HY, Sun CK, Lin YC, Leu S, Chung SY, Chai HT, Yang
CH, Hsien YK, Wu CJ, Yip HK. Benefit of revascularization in non-infarct-related
artery in multivessel disease patients with ST-segment elevation myocardial
infarction undergoing primary percutaneous coronary intervention. Int Heart J.
2010;51(5):319-24. doi: 10.1536/ihj.51.319. PMID: 20966603.
99: Chang HW, Leu S, Sun CK, Hang CL, Youssef AA, Hsieh YK, Yang CH, Cheng CI,
Chen SM, Chen CJ, Chua S, Chang LT, Wu CJ, Yip HK. Level and value of
circulating endothelial progenitor cells in patients with acute myocardial
infarction undergoing primary coronary angioplasty: in vivo and in vitro
studies. Transl Res. 2010 Oct;156(4):251-63. doi: 10.1016/j.trsl.2010.07.010.
Epub 2010 Aug 25. PMID: 20875902.
100: Lin YC, Leu S, Sun CK, Yen CH, Kao YH, Chang LT, Tsai TH, Chua S, Fu M, Ko
SF, Wu CJ, Lee FY, Yip HK. Early combined treatment with sildenafil and adipose-
derived mesenchymal stem cells preserves heart function in rat dilated
cardiomyopathy. J Transl Med. 2010 Sep 26;8:88. doi: 10.1186/1479-5876-8-88.
PMID: 20868517; PMCID: PMC2956711.
101: Sheu JJ, Sun CK, Chang LT, Fang HY, Chung SY, Chua S, Fu M, Lee FY, Kao YH,
Ko SF, Wang CJ, Yen CH, Leu S, Yip HK. Shock wave-pretreated bone marrow cells
further improve left ventricular function after myocardial infarction in
rabbits. Ann Vasc Surg. 2010 Aug;24(6):809-21. doi: 10.1016/j.avsg.2010.03.027.
PMID: 20638620.
102: Tsai TH, Chai HT, Sun CK, Leu S, Fan CQ, Zhang ZH, Fang HY, Youssef AA,
Hussein H, Yang CH, Wu CJ, Yip HK. Comparison of 30-day mortality between
anterior-wall versus inferior-wall ST-segment elevation myocardial infarction
complicated by cardiogenic shock in patients undergoing primary coronary
angioplasty. Cardiology. 2010;116(2):144-50. doi: 10.1159/000317252. Epub 2010
Jul 3. PMID: 20606428.
103: Yuen CM, Leu S, Lee FY, Yen CH, Lin YC, Chua S, Chung SY, Chai HT, Sheu JJ,
Ko SF, Sun CK, Yip HK. Erythropoietin markedly attenuates brain infarct size and
improves neurological function in the rat. J Investig Med. 2010
Oct;58(7):893-904. doi: 10.231/JIM.0b013e3181e80c40. PMID: 20601898.
104: Leu S, Lin YC, Yuen CM, Yen CH, Kao YH, Sun CK, Yip HK. Adipose-derived
mesenchymal stem cells markedly attenuate brain infarct size and improve
neurological function in rats. J Transl Med. 2010 Jun 28;8:63. doi:
10.1186/1479-5876-8-63. PMID: 20584315; PMCID: PMC2913939.
105: Sheu JJ, Tsai TH, Lee FY, Fang HY, Sun CK, Leu S, Yang CH, Chen SM, Hang
CL, Hsieh YK, Chen CJ, Wu CJ, Yip HK. Early extracorporeal membrane oxygenator-
assisted primary percutaneous coronary intervention improved 30-day clinical
outcomes in patients with ST-segment elevation myocardial infarction complicated
with profound cardiogenic shock. Crit Care Med. 2010 Sep;38(9):1810-7. doi:
10.1097/CCM.0b013e3181e8acf7. PMID: 20543669.
106: Leu S, Sun CK, Sheu JJ, Chang LT, Yuen CM, Yen CH, Chiang CH, Ko SF, Pei
SN, Chua S, Youssef AA, Wu CJ, Yip HK. Autologous bone marrow cell implantation
attenuates left ventricular remodeling and improves heart function in porcine
myocardial infarction: an echocardiographic, six-month angiographic, and
molecular-cellular study. Int J Cardiol. 2011 Jul 15;150(2):156-68. doi:
10.1016/j.ijcard.2010.03.007. Epub 2010 May 13. PMID: 20466442.
107: Yen CH, Leu S, Lin YC, Kao YH, Chang LT, Chua S, Fu M, Wu CJ, Sun CK, Yip
HK. Sildenafil limits monocrotaline-induced pulmonary hypertension in rats
through suppression of pulmonary vascular remodeling. J Cardiovasc Pharmacol.
2010 Jun;55(6):574-84. doi: 10.1097/FJC.0b013e3181d9f5f4. PMID: 20224427.
108: Leu S, Ouyang P. Spatial and temporal expression profile of pinin during
mouse development. Gene Expr Patterns. 2006 Aug;6(6):620-31. doi:
10.1016/j.modgep.2005.11.009. Epub 2006 Jan 20. PMID: 16427813.
109: Lin CL, Leu S, Lu MC, Ouyang P. Over-expression of SR-cyclophilin, an
interaction partner of nuclear pinin, releases SR family splicing factors from
nuclear speckles. Biochem Biophys Res Commun. 2004 Aug 27;321(3):638-47. doi:
10.1016/j.bbrc.2004.07.013. PMID: 15358154.
110: Chang WL, Lee DC, Leu S, Huang YM, Lu MC, Ouyang P. Molecular
characterization of a novel nucleolar protein, pNO40. Biochem Biophys Res
Commun. 2003 Aug 1;307(3):569-77. doi: 10.1016/s0006-291x(03)01208-7. PMID:
12893261.
111: Wang P, Lou PJ, Leu S, Ouyang P. Modulation of alternative pre-mRNA
splicing in vivo by pinin. Biochem Biophys Res Commun. 2002 Jun 7;294(2):448-55.
doi: 10.1016/S0006-291X(02)00495-3. PMID: 12051732.
研究團隊
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陳俐璇研究助理
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邱于均研究助理
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林佑宏研究助理
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林宥禎工讀生
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蔡秀玟工讀生
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學術履歷
Education
1998-2005 Ph.D. Graduate Institute of Basic Medical Science,
Chang Gung University, Taoyuan, Taiwan
1996-1998 M.S. Graduate Institute of Basic Medical Science,
Chang Gung University, Taoyuan, Taiwan
1992-1996 B.S. Department of Biology, National Sun-Yet-Sen University,
Kaohsiung, Taiwan
Experience
2011- Assistant Professor, Kaohsiung Chang Gung Memorial Hospital
2009-2011 Adjunct Assistant Professor, Meiho University
2005-2011 Postdoctal fellow, Chang Gung University
Research Interests and experiments
Cardiovascular disease
Animal model of disease
Cytotherapy
Transgenic animal model
Transcriptional regulation and mRNA splicing
Cell differentiation and Apoptosis
Awards
The AAROC 9th Ph.D. student thesis award, excellent work, 1st place