
呂史提
教授
心血管疾病
神經退化性疾病
幹細胞治療
基因轉殖動物模式
- 聯絡電話
- 電子郵件信箱
leu@cgmh.org.tw
leu@mail.cgu.edu.tw
Steve Leu obtained his Bachelor of Science degree from Department of Biology, National Sun Yat-Sen University, Taiwan in 1996. He went on to further his studies, working on characterization of mRNA splicing factors and generation of transgenic and knock-out mouse models, and received his PhD degree from Graduated Institute of Biomedical Sciences, Chang Gung University, Taiwan in 2005. He also received the PhD student thesis award of the Association of Anatomists of the Republic of China, scoring first place. During the postdoctoral training, he participated in generating conditional knockout mouse models to investigate the temporal and spatial-specific function of mRNA splicing factors in vivo, as well as in determining the relationship between mRNA splicing factors and apoptotic events. Besides, he also joined the cardiovascular research team in Kaohsiung Chang Gung Memorial Hospital, Taiwan, working on utilization of mesenchymal stem cell-based therapy in cardiovascular disease animal models. His research interests include disease animal models of cardiovascular disease, stem cell therapy, developmental programing of metabolic syndromes, and translational research in cardiovascular diseases.
Selected recent publications (Pubmed Search)
(† Contributed equally to the article; * Correspondence author of the article)
Chiang HJ, Hsu SY, Leu S*. Comparable Protective Effects of Low- and High-Dose MK-7 on Bone Structure and Remodeling in a Rat Model of Osteoporosis Induced by Estrogen Deficiency and Glucocorticoid Exposure. Nutrients, 18(10):1605 (2026)
Chiang HJ, Hsiao CC, Leu S*. Estrogen Enhances Endothelial Differentiation and Angiogenic Function of Adipose-Derived Stromal Cells to Improve Therapeutic Outcomes in Critical Limb Ischemia. Cells, 15(10):885 (2026)
Chang CC, Chen CH, Hsu SY, Leu S*. Cardiomyocyte-specific overexpression of GPR22 ameliorates cardiac injury in mice with acute myocardial infarction. BMC Cardiovascular Disorders, 24(1):287 (2024)
Hsu SY, Chen CH, Mukda S, Leu S*. Neuronal Pnn Deficiency Increases Oxidative Stress and Exacerbates Cerebral Ischemia/Reperfusion Injury in Mice. Antioxidants, 11(3):466 (2022)
Leu S*. The role and regulation of Pnn in proliferative and non-dividing cells: From embryogenesis to pathogenesis. Biochemical Pharmacology, 192:114672 (2021)
Leu S*, Wu KLH, Lee WC, Tain YL, Chan JYH. Maternal Fructose Intake Exacerbates Cardiac Remodeling in Offspring with Ventricular Pressure Overload. Nutrients, 13(9):3267 (2021)
Hsu SY, Mukda S, Leu S*. Expression and Distribution Pattern of Pnn in Ischemic Cerebral Cortex and Cultured Neural Cells Exposed to Oxygen-Glucose Deprivation. Brain Sciences, 10(10):708 (2020)
Chen CH, Hsu SY, Chiu CC, Leu S*. MicroRNA-21 Mediates the Protective Effect of Cardiomyocyte-Derived Conditioned Medium on Ameliorating Myocardial Infarction in Rats. Cells, 8(8):935 (2019)
Leu S*, Wu KLH, Lee WC, Tain YL, Chan JYH. The Impact of Maternal Fructose Exposure on Angiogenic Activity of Endothelial Progenitor Cells and Blood Flow Recovery After Critical Limb Ischemia in Rat Offspring. International Journal of Molecular Sciences, 20(10):2429 (2019)
Leu S, Day YJ, Sun CK, Yip HK. tPA-MMP-9 Axis Plays a Pivotal Role in Mobilization of Endothelial Progenitor Cells from Bone Marrow to Circulation and Ischemic Region for Angiogenesis. Stem Cells International, 2016:5417565 (2016)
Chai HT, Yip HK, Sun CK, Hsu SY, Leu S*. AG490 suppresses EPO-mediated activation of JAK2-STAT but enhances blood flow recovery in rats with critical limb ischemia. Journal of Inflammation, 13:18 (2016)
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陳俐璇研究助理
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邱于均研究助理
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林佑宏研究助理
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林宥禎工讀生
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蔡秀玟工讀生
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Education
1998-2005 Ph.D. Graduate Institute of Basic Medical Science,
Chang Gung University, Taoyuan, Taiwan
1996-1998 M.S. Graduate Institute of Basic Medical Science,
Chang Gung University, Taoyuan, Taiwan
1992-1996 B.S. Department of Biology, National Sun-Yet-Sen University,
Kaohsiung, Taiwan
Experience
2011- Assistant Professor, Kaohsiung Chang Gung Memorial Hospital
2009-2011 Adjunct Assistant Professor, Meiho University
2005-2011 Postdoctal fellow, Chang Gung University
Research Interests and experiments
Cardiovascular disease
Animal model of disease
Cytotherapy
Transgenic animal model
Transcriptional regulation and mRNA splicing
Cell differentiation and Apoptosis
Awards
The AAROC 9th Ph.D. student thesis award, excellent work, 1st place





