Members

Selected recent publications (Pubmed Search)
(† Contributed equally to the article; * Correspondence author of the article)

1. Tseng YJ, Lee CH, Chen WY, Yang JL, Tzeng HT*. Inhibition of PAI-1 Blocks PD-L1 Endocytosis and Improves the Response of Melanoma Cells to Immune Checkpoint Blockade. J Invest Dermatol. S0022-202X(21)01230-6 (2021).
2. Tzeng HT*, Yang JL, Tseng YJ, Lee CH, Chen WJ, Chyuan IT*. Plasminogen Activator Inhibitor-1 Secretion by Autophagy Contributes to Melanoma Resistance to Chemotherapy through Tumor Microenvironment Modulation. Cancers (Basel). 13(6):1253 (2021).
3. Tzeng HT, Chyuan IT*. Immunometabolism in systemic lupus erythematosus: Relevant pathogenetic mechanisms and potential clinical applications. J Formos Med Assoc. S0929-6646(21)00124-8 (2021).
4. Chen WY, Li LC, Wu YH, Yang JL, Tzeng HT*. Emerging Roles of Interleukin-33-responsive Kidney Group 2 Innate Lymphoid Cells in Acute Kidney Injury. Int J Mol Sci. 21(4):1544 (2020).
5. Tzeng HT, Chyuan IT, Chen WY*. Shaping of Innate Immune Response by Fatty Acid Metabolite Palmitate. Cells. 8(12):1633 (2019).
6. Wang YS^†, Tzeng HT^†, Tsai CH, Cheng HC, Lai WW, Liu HS, Wang YC*. VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function. Cancer Lett. 28: 437:79-88 (2018).
7. Tzeng HT, Su CC, Chang CP, Lai WW, Su WC, Wang YC*. Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages toward tumor-suppressing phenotype. Int J Cancer. 143: 1753-63 (2018).
8. Tzeng HT, Li TH, Tang YA, Tsai CH, Lu PJ, Lai WW, Chiang CW, Wang YC*. Phosphorylation of Rab37 by protein kinase C alpha inhibits the exocytosis function and metastasis suppression activity of Rab37. Oncotarget, 8(65):108556-70 (2017).
9. Tzeng HT^†, Tsai CH^†, Yen YT^†, Cheng HC, Chen YC, Pu SW, Wang YS, Shan YS, Tseng YL, Su WC, Lai WW, Wu LW, Wang YC*. Dysregulation of Rab37-mediated cross-talk between cancer cells and endothelial cells via thrombospondin-1 promotes tumor neovasculature and metastasis. Clin Cancer Res, 23(9):2335-2345 (2017).
10. Tzeng HT, Wang YC*. Rab-mediated vesicle trafficking in cancer. J Biomed Sci, 23(1):70 (2016).

EDUCATION:

2007 – 2014 Ph.D.
Graduate Institute of Immunology, College of Medicine,
National Taiwan University, Taipei, Taiwan

PROFESSIONAL EXPERIENCE:

2018/8 ~ present Assistant Professor
Institute for Translational Research in Biomedicine,
Kaohsiung Chang Gung Memorial Hospital,
Kaohsiung, Taiwan

2014/8 ~ 2018/7 Postdoctoral Research Fellow
Department of Pharmacology, College of Medicine,
National Cheng Kung University, Tainan, Taiwan

AWARDS AND RESEARCH SUPPORT:

2017 The third Prize (oral presentation in English), Autumn Camp 2017, The Taiwan Society for
Biochemistry and Molecular Biology
2017 The Second Prize (Thematic oral presentation), 32th Joint Annual Conference of Biomedical
Science (JACBS)
2016 The First Prize (oral presentation), 31th Annual Meeting of Toxicology Society of Taiwan
2016 Travel Grant, International Academic Conference, Ministry of Science and Technology
2012 Travel Grant, Oversea International Academic Conference, Ministry of Education
2012 Travel Grant, aim for the top University Project to the National Taiwan University
2012 Excellent paper Award (oral presentation), The Chinese Society of Immunology
2011 Excellent paper Award (oral presentation), The Chinese Society of Immunology
2010 Excellent paper Award (oral presentation), The Chinese Society of Immunology

RESEARCH INTERESTS:

1. Viral immunology of infectious disease
2. Regulation of T cell activation in cancer
3. Development of immunotherapy for cancer treatment