{"id":2741,"date":"2019-09-11T00:06:05","date_gmt":"2019-09-10T16:06:05","guid":{"rendered":"https:\/\/itrbm.org\/tw\/?page_id=2741"},"modified":"2026-08-28T09:40:21","modified_gmt":"2026-08-28T01:40:21","slug":"leu-s","status":"publish","type":"page","link":"https:\/\/itrbm.org\/tw\/members\/leu-s\/","title":{"rendered":"\u5442\u53f2\u63d0 \u6559\u6388"},"content":{"rendered":"<div id='av_section_1' class='avia-section main_color avia-section-large avia-no-border-styling avia-full-stretch av-section-color-overlay-active avia-bg-style-scroll  avia-builder-el-0  el_before_av_one_fourth  avia-builder-el-first   container_wrap sidebar_left' style='background-repeat: no-repeat; background-image: url(https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/03\/dna-1.jpg);background-attachment: scroll; background-position: center center;  '  data-section-bg-repeat='stretch'><div class='av-section-color-overlay-wrap'><div class='av-section-color-overlay' style='opacity: 0.2; background-color: #000000; '><\/div><div class='container' ><main  role=\"main\" itemprop=\"mainContentOfPage\"  class='template-page content  av-content-small units'><div class='post-entry post-entry-type-page post-entry-2741'><div class='entry-content-wrapper clearfix'>\n<div style='padding-bottom:10px; color:#ffffff;font-size:44px;' class='av-special-heading av-special-heading-h1 custom-color-heading blockquote modern-quote modern-centered  avia-builder-el-1  avia-builder-el-no-sibling  av-inherit-size '><h1 class='av-special-heading-tag '  itemprop=\"headline\"  >\u6210\u54e1\u4ecb\u7d39<\/h1><div class='special-heading-border'><div class='special-heading-inner-border' style='border-color:#ffffff'><\/div><\/div><\/div>\n<\/div><\/div><\/main><!-- close content main element --><\/div><\/div><\/div><div id='after_section_1' class='main_color av_default_container_wrap container_wrap sidebar_left' style=' '  ><div class='container' ><div class='template-page content  av-content-small units'><div class='post-entry post-entry-type-page post-entry-2741'><div class='entry-content-wrapper clearfix'>\n<div class=\"flex_column av_one_fourth  flex_column_div av-zero-column-padding first  avia-builder-el-2  el_after_av_section  el_before_av_one_fourth  avia-builder-el-first  \" style='border-radius:0px; '><div class='avia-image-container  av-styling-    avia-builder-el-3  avia-builder-el-no-sibling  avia-align-left '  itemprop=\"ImageObject\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><img class='avia_image' src='https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2025\/05\/9B2A2900-LeuS_240.jpg' alt='' title='9B2A2900 LeuS 240' height=\"240\" width=\"180\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div><\/div>\n<div class=\"flex_column av_one_fourth  flex_column_div av-zero-column-padding   avia-builder-el-4  el_after_av_one_fourth  el_before_av_one_half  \" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3><strong><span style=\"font-size: 20px; color: #109bc5;\">\u5442\u53f2\u63d0<\/span><\/strong><br \/>\n<span style=\"font-size: 16px; color: #333333;\">\u6559\u6388<\/span><\/h3>\n<h5><span style=\"color: #333333;\">\u5fc3\u8840\u7ba1\u75be\u75c5<\/span><br \/>\n<span style=\"color: #333333;\">\u795e\u7d93\u9000\u5316\u6027\u75be\u75c5<\/span><br \/>\n<span style=\"color: #333333;\">\u5e79\u7d30\u80de\u6cbb\u7642<\/span><br \/>\n<span style=\"color: #333333;\">\u57fa\u56e0\u8f49\u6b96\u52d5\u7269\u6a21\u5f0f<\/span><\/h5>\n<\/div><\/section><\/div>\n<div class=\"flex_column av_one_half  flex_column_div av-zero-column-padding   avia-builder-el-6  el_after_av_one_fourth  el_before_av_hr  \" style='border-radius:0px; '><div class='avia-icon-list-container   avia-builder-el-7  avia-builder-el-no-sibling '><ul class='avia-icon-list avia-icon-list-left av-iconlist-small avia_animate_when_almost_visible avia-iconlist-animate'>\n<li><div  style='font-size:14px; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue854' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><div class='av_iconlist_title iconlist_title_small  '  itemprop=\"headline\"   style='font-size:14px; '>\u806f\u7d61\u96fb\u8a71<\/div><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><h5>(07) 731-7123 ext 8591<\/h5>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<li><div  style='font-size:14px; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue805' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><div class='av_iconlist_title iconlist_title_small  '  itemprop=\"headline\"   style='font-size:14px; '>\u96fb\u5b50\u90f5\u4ef6\u4fe1\u7bb1<\/div><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><h5>leu@cgmh.org.tw<\/h5>\n<h5>leu@mail.cgu.edu.tw<\/h5>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<\/ul><\/div><\/div>\n<div style='height:20px' class='hr hr-invisible   avia-builder-el-8  el_after_av_one_half  el_before_av_tab_container '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div>\n<div class=\"tabcontainer   top_tab   avia-builder-el-9  el_after_av_hr  avia-builder-el-last \">\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-1\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-1\" class=\"tab active_tab\"  itemprop=\"headline\" ><span class='tab_icon' aria-hidden='true' data-av_icon='\ue864' data-av_iconfont='entypo-fontello'><\/span>\u500b\u4eba\u7c21\u4ecb<\/div>\n    <div id=\"tab-id-1-container\" class=\"tab_content active_tab_content\" aria-hidden=\"false\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<p>Steve Leu obtained his Bachelor of Science degree from Department of Biology, National Sun Yat-Sen University, Taiwan in 1996. He went on to further his studies, working on characterization of mRNA splicing factors and generation of transgenic and knock-out mouse models, and received his PhD degree from Graduated Institute of Biomedical Sciences, Chang Gung University, Taiwan in 2005. He also received the PhD student thesis award of the Association of Anatomists of the Republic of China, scoring first place. During the postdoctoral training, he participated in generating conditional knockout mouse models to investigate the temporal and spatial-specific function of mRNA splicing factors in vivo, as well as in determining the relationship between mRNA splicing factors and apoptotic events. Besides, he also joined the cardiovascular research team in Kaohsiung Chang Gung Memorial Hospital, Taiwan, working on utilization of mesenchymal stem cell-based therapy in cardiovascular disease animal models. His research interests include disease animal models of cardiovascular disease, stem cell therapy, developmental programing of metabolic syndromes, and translational research in cardiovascular diseases.<\/p>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-2\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-2\" class=\"tab \"  itemprop=\"headline\" ><span class='tab_icon' aria-hidden='true' data-av_icon='\ue836' data-av_iconfont='entypo-fontello'><\/span>\u5b78\u8853\u8457\u4f5c<\/div>\n    <div id=\"tab-id-2-container\" class=\"tab_content \" aria-hidden=\"true\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<p><strong>Selected recent publications (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Leu%2C+Steve\" target=\"_blank\" rel=\"noopener\">Pubmed Search<\/a>)<br \/>\n<\/strong> (\u2020 Contributed equally to the article; * Correspondence author of the article)<\/p>\n<p>Chiang HJ, Hsu SY, <strong>Leu S*<\/strong>. <em>Comparable Protective Effects of Low- and High-Dose MK-7 on Bone Structure and Remodeling in a Rat Model of Osteoporosis Induced by Estrogen Deficiency and Glucocorticoid Exposure.<\/em> Nutrients, 18(10):1605 (2026)<\/p>\n<p>Chiang HJ, Hsiao CC, <strong>Leu S*<\/strong>. <em>Estrogen Enhances Endothelial Differentiation and Angiogenic Function of Adipose-Derived Stromal Cells to Improve Therapeutic Outcomes in Critical Limb Ischemia.<\/em> Cells, 15(10):885 (2026)<\/p>\n<p>Chang CC, Chen CH, Hsu SY, <strong>Leu S*<\/strong>. <em>Cardiomyocyte-specific overexpression of GPR22 ameliorates cardiac injury in mice with acute myocardial infarction.<\/em> BMC Cardiovascular Disorders, 24(1):287 (2024)<\/p>\n<p>Hsu SY, Chen CH, Mukda S, <strong>Leu S*<\/strong>. <em>Neuronal Pnn Deficiency Increases Oxidative Stress and Exacerbates Cerebral Ischemia\/Reperfusion Injury in Mice.<\/em> Antioxidants, 11(3):466 (2022)<\/p>\n<p><strong>Leu S*<\/strong>. <em>The role and regulation of Pnn in proliferative and non-dividing cells: From embryogenesis to pathogenesis.<\/em> Biochemical Pharmacology, 192:114672 (2021)<\/p>\n<p><strong>Leu S*<\/strong>, Wu KLH, Lee WC, Tain YL, Chan JYH. <em>Maternal Fructose Intake Exacerbates Cardiac Remodeling in Offspring with Ventricular Pressure Overload.<\/em> Nutrients, 13(9):3267 (2021)<\/p>\n<p>Hsu SY, Mukda S, <strong>Leu S*<\/strong>. <em>Expression and Distribution Pattern of Pnn in Ischemic Cerebral Cortex and Cultured Neural Cells Exposed to Oxygen-Glucose Deprivation.<\/em> Brain Sciences, 10(10):708 (2020)<\/p>\n<p>Chen CH, Hsu SY, Chiu CC, <strong>Leu S*<\/strong>. <em>MicroRNA-21 Mediates the Protective Effect of Cardiomyocyte-Derived Conditioned Medium on Ameliorating Myocardial Infarction in Rats.<\/em> Cells, 8(8):935 (2019)<\/p>\n<p><strong>Leu S*<\/strong>, Wu KLH, Lee WC, Tain YL, Chan JYH. <em>The Impact of Maternal Fructose Exposure on Angiogenic Activity of Endothelial Progenitor Cells and Blood Flow Recovery After Critical Limb Ischemia in Rat Offspring.<\/em> International Journal of Molecular Sciences, 20(10):2429 (2019)<\/p>\n<p><strong>Leu S<\/strong>, Day YJ, Sun CK, Yip HK. <em>tPA-MMP-9 Axis Plays a Pivotal Role in Mobilization of Endothelial Progenitor Cells from Bone Marrow to Circulation and Ischemic Region for Angiogenesis.<\/em> Stem Cells International, 2016:5417565 (2016)<\/p>\n<p>Chai HT, Yip HK, Sun CK, Hsu SY, <strong>Leu S*<\/strong>. <em>AG490 suppresses EPO-mediated activation of JAK2-STAT but enhances blood flow recovery in rats with critical limb ischemia.<\/em> Journal of Inflammation, 13:18 (2016)<\/p>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-3\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-3\" class=\"tab \"  itemprop=\"headline\" ><span class='tab_icon' aria-hidden='true' data-av_icon='\ue80b' data-av_iconfont='entypo-fontello'><\/span>\u7814\u7a76\u5718\u968a<\/div>\n    <div id=\"tab-id-3-container\" class=\"tab_content \" aria-hidden=\"true\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<h4><\/h4>\n<table style=\"table-layout: fixed;\" width=\"720\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td bgcolor=\"#FFFFFF\">\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-3071 size-full\" src=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2020\/02\/ChenLH270.jpg\" alt=\"\" width=\"180\" height=\"270\" \/><\/p>\n<h4 style=\"text-align: center;\"><strong>\u9673\u4fd0\u7487<\/strong><\/h4>\n<h5 style=\"text-align: center;\">\u7814\u7a76\u52a9\u7406<br \/>\nResearch Assistant<\/h5>\n<\/td>\n<td bgcolor=\"#FFFFFF\">\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-3072 size-full\" src=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2020\/02\/ChiuYC270.jpg\" alt=\"\" width=\"180\" height=\"270\" \/><\/p>\n<h4 style=\"text-align: center;\"><strong>\u90b1\u4e8e\u5747<\/strong><\/h4>\n<h5 style=\"text-align: center;\">\u7814\u7a76\u52a9\u7406<br \/>\nSenior Secretory<\/h5>\n<\/td>\n<td bgcolor=\"#FFFFFF\">\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-3069 size-full\" src=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2020\/02\/LinYH270.jpg\" alt=\"\" width=\"180\" height=\"270\" \/><\/p>\n<h4 style=\"text-align: center;\"><strong>\u6797\u4f51\u5b8f<\/strong><\/h4>\n<h5 style=\"text-align: center;\">\u7814\u7a76\u52a9\u7406<br \/>\nResearch Assistant<\/h5>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table style=\"table-layout: fixed;\" width=\"480\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td bgcolor=\"#FFFFFF\">\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-3073 size-full\" src=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2020\/02\/LinYC270.jpg\" alt=\"\" width=\"180\" height=\"270\" \/><\/p>\n<h4 style=\"text-align: center;\"><strong>\u6797\u5ba5\u798e<\/strong><\/h4>\n<h5 style=\"text-align: center;\">\u5de5\u8b80\u751f<br \/>\nPart-time Intern<\/h5>\n<\/td>\n<td bgcolor=\"#FFFFFF\">\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-3070 size-full\" src=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2020\/02\/TsaiHW270.jpg\" alt=\"\" width=\"180\" height=\"270\" \/><\/p>\n<h4 style=\"text-align: center;\"><strong>\u8521\u79c0\u739f<\/strong><\/h4>\n<h5 style=\"text-align: center;\">\u5de5\u8b80\u751f<br \/>\nPart-time Intern<\/h5>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-4\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-4\" class=\"tab \"  itemprop=\"headline\" ><span class='tab_icon' aria-hidden='true' data-av_icon='\ue840' data-av_iconfont='entypo-fontello'><\/span>\u5b78\u8853\u5c65\u6b77<\/div>\n    <div id=\"tab-id-4-container\" class=\"tab_content \" aria-hidden=\"true\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<div>\n<p align=\"left\"><strong>Education<\/strong><\/p>\n<\/div>\n<div>\n<p>1998-2005 Ph.D. Graduate Institute of Basic Medical Science,<br \/>\nChang Gung University, Taoyuan, Taiwan<\/p>\n<p>1996-1998 M.S. Graduate Institute of Basic Medical Science,<br \/>\nChang Gung University, Taoyuan, Taiwan<\/p>\n<p>1992-1996 B.S. Department of Biology, National Sun-Yet-Sen University,<br \/>\nKaohsiung, Taiwan<\/p>\n<p><strong>Experience<\/strong><\/p>\n<p>2011- Assistant Professor, Kaohsiung Chang Gung Memorial Hospital<br \/>\n2009-2011 Adjunct Assistant Professor, Meiho University<br \/>\n2005-2011 Postdoctal fellow, Chang Gung University<\/p>\n<p><strong>Research Interests and experiments<\/strong><\/p>\n<p>Cardiovascular disease<br \/>\nAnimal model of disease<br \/>\nCytotherapy<br \/>\nTransgenic animal model<br \/>\nTranscriptional regulation and mRNA splicing<br \/>\nCell differentiation and Apoptosis<\/p>\n<p><strong>Awards<br \/>\n<\/strong><\/p>\n<p>The AAROC 9<sup>th<\/sup> Ph.D. student thesis award, excellent work, 1<sup>st<\/sup> place<\/p>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<\/div>\n\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":443,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/itrbm.org\/tw\/wp-json\/wp\/v2\/pages\/2741"}],"collection":[{"href":"https:\/\/itrbm.org\/tw\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/itrbm.org\/tw\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/itrbm.org\/tw\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/itrbm.org\/tw\/wp-json\/wp\/v2\/comments?post=2741"}],"version-history":[{"count":19,"href":"https:\/\/itrbm.org\/tw\/wp-json\/wp\/v2\/pages\/2741\/revisions"}],"predecessor-version":[{"id":4889,"href":"https:\/\/itrbm.org\/tw\/wp-json\/wp\/v2\/pages\/2741\/revisions\/4889"}],"up":[{"embeddable":true,"href":"https:\/\/itrbm.org\/tw\/wp-json\/wp\/v2\/pages\/443"}],"wp:attachment":[{"href":"https:\/\/itrbm.org\/tw\/wp-json\/wp\/v2\/media?parent=2741"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}