{"id":2107,"date":"2019-06-27T23:39:09","date_gmt":"2019-06-27T15:39:09","guid":{"rendered":"https:\/\/itrbm.org\/tw\/?page_id=2107"},"modified":"2026-08-28T09:45:20","modified_gmt":"2026-08-28T01:45:20","slug":"chen-dw","status":"publish","type":"page","link":"https:\/\/itrbm.org\/tw\/members\/chen-dw\/","title":{"rendered":"\u9673\u5b9a\u6ff0 \u526f\u6559\u6388"},"content":{"rendered":"<div id='av_section_1' class='avia-section main_color avia-section-large avia-no-border-styling avia-full-stretch av-section-color-overlay-active avia-bg-style-scroll  avia-builder-el-0  el_before_av_one_fourth  avia-builder-el-first   container_wrap sidebar_left' style='background-repeat: no-repeat; background-image: url(https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/03\/dna-1.jpg);background-attachment: scroll; background-position: center center;  '  data-section-bg-repeat='stretch'><div class='av-section-color-overlay-wrap'><div class='av-section-color-overlay' style='opacity: 0.2; background-color: #000000; '><\/div><div class='container' ><main  role=\"main\" itemprop=\"mainContentOfPage\"  class='template-page content  av-content-small units'><div class='post-entry post-entry-type-page post-entry-2107'><div class='entry-content-wrapper clearfix'>\n<div style='padding-bottom:10px; color:#ffffff;font-size:44px;' class='av-special-heading av-special-heading-h1 custom-color-heading blockquote modern-quote modern-centered  avia-builder-el-1  avia-builder-el-no-sibling  av-inherit-size '><h1 class='av-special-heading-tag '  itemprop=\"headline\"  >\u6210\u54e1\u4ecb\u7d39<\/h1><div class='special-heading-border'><div class='special-heading-inner-border' style='border-color:#ffffff'><\/div><\/div><\/div>\n<\/div><\/div><\/main><!-- close content main element --><\/div><\/div><\/div><div id='after_section_1' class='main_color av_default_container_wrap container_wrap sidebar_left' style=' '  ><div class='container' ><div class='template-page content  av-content-small units'><div class='post-entry post-entry-type-page post-entry-2107'><div class='entry-content-wrapper clearfix'>\n<div class=\"flex_column av_one_fourth  flex_column_div av-zero-column-padding first  avia-builder-el-2  el_after_av_section  el_before_av_one_fourth  avia-builder-el-first  \" style='border-radius:0px; '><div class='avia-image-container  av-styling-    avia-builder-el-3  avia-builder-el-no-sibling  avia-align-left '  itemprop=\"ImageObject\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><img class='avia_image' src='https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2025\/05\/9B2A2525-ChenKD_240.jpg' alt='' title='9B2A2525 ChenKD 240' height=\"240\" width=\"180\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div><\/div>\n<div class=\"flex_column av_one_fourth  flex_column_div av-zero-column-padding   avia-builder-el-4  el_after_av_one_fourth  el_before_av_one_half  \" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3><strong><span style=\"font-size: 20px; color: #109bc5;\">\u9673\u5b9a\u6ff0<\/span><\/strong><br \/>\n<span style=\"font-size: 16px; color: #333333;\">\u526f\u6559\u6388<\/span><\/h3>\n<h5><span style=\"color: #333333;\">\u9ad8\u901a\u91cf\u7cfb\u7d71\u57fa\u56e0\u9ad4\u5b78<\/span><br \/>\n<span style=\"color: #333333;\">\u809d\u764c\u8207\u5206\u5b50\u91ab\u5b78<\/span><br \/>\n<span style=\"color: #333333;\">\u809d\u814e\u4ee3\u8b1d\u75be\u75c5\u7684\u52d5\u7269\u6a21\u5f0f<\/span><\/h5>\n<\/div><\/section><\/div>\n<div class=\"flex_column av_one_half  flex_column_div av-zero-column-padding   avia-builder-el-6  el_after_av_one_fourth  el_before_av_hr  \" style='border-radius:0px; '><div class='avia-icon-list-container   avia-builder-el-7  avia-builder-el-no-sibling '><ul class='avia-icon-list avia-icon-list-left av-iconlist-small avia_animate_when_almost_visible avia-iconlist-animate'>\n<li><div  style='font-size:14px; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue854' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><div class='av_iconlist_title iconlist_title_small  '  itemprop=\"headline\"   style='font-size:14px; '>\u806f\u7d61\u96fb\u8a71<\/div><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><h5>(07) 731-7123 ext 8880<\/h5>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<li><div  style='font-size:14px; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue805' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><div class='av_iconlist_title iconlist_title_small  '  itemprop=\"headline\"   style='font-size:14px; '>\u96fb\u5b50\u90f5\u4ef6\u4fe1\u7bb1<\/div><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><h5>dennis8857@gmail.com<\/h5>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<\/ul><\/div><\/div>\n<div style='height:20px' class='hr hr-invisible   avia-builder-el-8  el_after_av_one_half  el_before_av_tab_container '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div>\n<div class=\"tabcontainer   top_tab   avia-builder-el-9  el_after_av_hr  avia-builder-el-last \">\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-1\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-1\" class=\"tab active_tab\"  itemprop=\"headline\" ><span class='tab_icon' aria-hidden='true' data-av_icon='\ue864' data-av_iconfont='entypo-fontello'><\/span>\u7814\u7a76\u7c21\u4ecb<\/div>\n    <div id=\"tab-id-1-container\" class=\"tab_content active_tab_content\" aria-hidden=\"false\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<p>\u60e1\u6027\u809d\u816b\u7624\uff0c\u5c24\u5176\u662f\u809d\u7d30\u80de\u764c (hepatocellular carcinoma)\uff0c\u662f\u5168\u7403\u75be\u75c5\u6b7b\u4ea1\u7684\u4e3b\u8981\u56e0\u7d20\u4e4b\u4e00\u3002 \u816b\u7624\u7d30\u80de\u8207\u5176\u5468\u570d\u7d30\u80de\u4e4b\u9593\u7684\u76f8\u4e92\u4f5c\u7528\u548c\u6e9d\u901a\u5f62\u6210\u816b\u7624\u5fae\u74b0\u5883 (Tumor microenvironments)\uff0c\u5c0d\u65bc\u9020\u6210\u5c40\u90e8\u4fb5\u8972\u548c\u9060\u8655\u8f49\u79fb\u81f3\u95dc\u91cd\u8981\u3002 \u5728\u816b\u7624\u767c\u5c55\u904e\u7a0b\u4e2d\uff0c\u514d\u75ab\u6291\u5236\u56e0\u5b50\u5f9e\u764c\u7d30\u80de\u4e2d\u91cb\u653e\uff0c\u4f34\u96a8\u8457\u809d\u816b\u7624\u7684\u5f37\u70c8\u514d\u75ab\u81f4\u767c\u751f\u7279\u5fb5\uff0c\u662f\u9003\u907f\u816b\u7624\u514d\u75ab\u76e3\u8996\u7684\u95dc\u9375\uff0c\u4e26\u9650\u5236\u4e86\u514d\u75ab\u7642\u6cd5\u7684\u6cbb\u7642\u6548\u76ca\u3002\u5177\u9ad4\u800c\u8a00\uff0c\u76ee\u524d\u5df2\u77e5\u81ea\u566c\u4f5c\u7528 (Autophagy) \u5728\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u626e\u6f14\u4e3b\u8981\u89d2\u8272\uff0c\u5176\u5728\u514d\u75ab\u6291\u5236\u548c\u4fc3\u9032\u816b\u7624\u60e1\u6027\u5316\u7684\u6a5f\u5236\u4e0a\u5e38\u6709\u76f8\u4e92\u77db\u76fe\u7684\u7d50\u679c\u3002\u809d\u7d30\u80de\u764c\u9032\u5c55\u548c\u8f49\u79fb\u8207\u81ea\u566c\u4f5c\u7528\u7684\u95dc\u4fc2\uff0c\u4ecd\u662f\u65e5\u76ca\u53d7\u5230\u95dc\u6ce8\u7684\u7814\u7a76\u9818\u57df\u3002<\/p>\n<p>\u6211\u5011\u8fd1\u671f\u7684\u81e8\u5e8a\u548c\u5be6\u9a57\u8b49\u64da\u986f\u793a\uff0c\u809d\u764c\u7d30\u80de\u7684\u81ea\u566c\u6291\u5236\u53ef\u80fd\u6709\u52a9\u65bc\u52a0\u901f\u816b\u7624\u7684\u751f\u9577\u548c\u8f49\u79fb\u7684\u9032\u884c\uff0c\u5176\u5fae\u74b0\u5883\u7684\u63a2\u8a0e\u5c0d\u65bc\u9032\u4e00\u6b65\u7684\u9810\u9632\u548c\u6cbb\u7642\u975e\u5e38\u91cd\u8981\u3002\u56e0\u6b64\uff0c\u6211\u5011\u5f9e\u57fa\u790e\u7406\u8ad6\u4e0a\u5c07\u8108\u7ba1\u7cfb\u7d71\uff0c\u708e\u75c7\u63a7\u5236\uff0c\u51dd\u8840\u548c\u514d\u75ab\u529b\u7684\u89d2\u8272\uff0c\u4f5c\u70ba\u6539\u5584\u809d\u81df\u5fae\u74b0\u5883\u4ee5\u9810\u9632\u53ca\u6cbb\u7642\u809d\u764c\u7684\u7814\u7a76\u76ee\u6a19\uff0c\u4e26\u8457\u91cd\u65bc\u8207\u81ea\u566c\u4f5c\u7528\u76f8\u95dc\u7684\u5206\u5b50\u4e8b\u4ef6\uff08\u9776\u6a19\u8207\u8abf\u7bc0\u56e0\u5b50\uff09\u3002\u5728\u904e\u53bb\u5169\u5e74\u4e2d\uff0c\u6211\u5011\u7279\u5225\u7814\u7a76\u4e86\u9ad8\u8868\u9054\u51dd\u8840\u56e0\u5b50 Factor VII \u7684\u809d\u816b\u7624\u7d44\u7e54\u4e2d\uff0c\u5fae\u5c0f\u6838\u91a3\u6838\u9178 miR-135a \u4fc3\u9032\u809d\u7d30\u80de\u764c\u9032\u5c55\u7684\u5206\u5b50\u6a5f\u5236\u3002<\/p>\n<p>\u6211\u5011\u4e5f\u9032\u4e00\u6b65\u5206\u6790 Factor VII \u4fc3\u9032\u5fa9\u767c\u548c\u8f49\u79fb\u7684\u6a5f\u5236\uff0c\u5176\u53ef\u80fd\u53c3\u8207\u4e00\u7cfb\u5217\u4fc3\u767c\u751f\u9577\u3001\u4fb5\u8972\u548c\u8abf\u7bc0\u4e0a\u76ae\u2212\u9593\u8cea\u8f49\u5316\u53ef\u5851\u6027 (Epithelial-to-Mesenchymal Transition, EMT Plasticity) \u529f\u80fd\u7684\u8a0a\u865f\u50b3\u905e\u8def\u5f91\u3002<\/p>\n<p><strong>\u51dd\u8840\u56e0\u5b50 Factor VII <\/strong><strong>\u8a0a\u865f\u50b3\u905e\u5f15\u767c\u7684\u81ea\u566c\u6291\u5236\u5c0e\u56e0\u65bc miR-135a <\/strong><strong>\u7684\u904e\u5ea6\u8868\u9054\uff0c\u8207\u809d\u816b\u7624\u60e1\u6027\u5316\u9ad8\u5ea6\u76f8\u95dc\u3002<\/strong><\/p>\n<p>\u7814\u7a76\u8b49\u5be6\u809d\u816b\u7624\u4e2d Factor VII \u548c miR-135a \u7684\u8868\u9054\u5b58\u5728\u986f\u8457\u7684\u6b63\u76f8\u95dc\uff0c\u4e14 miR-135a \u548c\u81ea\u566c\u86cb\u767d ATG14 \u8868\u9054\u91cf\u6709\u986f\u8457\u8ca0\u76f8\u95dc\u3002\u8207\u9130\u8fd1\u6b63\u5e38\u809d\u7d44\u7e54\u5340\u57df\u76f8\u6bd4\uff0c\u816b\u7624\u5177\u6709\u9ad8\u8868\u9054 miR-135a \u7684\u809d\u764c\u60a3\u8005\uff0c\u5176\u7121\u75be\u75c5\u5b58\u6d3b\u7387 (disease-free survival) \u9060\u4f4e\u65bc\u816b\u7624\u4e2d\u4f4e miR-135a \u8868\u9054\u7684\u60a3\u8005\u3002<\/p>\n<p><a href=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/miR-135a-Atg14-01.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2116\" src=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/miR-135a-Atg14-01-495x400.png\" alt=\"\" width=\"400\" height=\"205\" srcset=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/miR-135a-Atg14-01-300x154.png 300w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/miR-135a-Atg14-01-768x395.png 768w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/miR-135a-Atg14-01-705x362.png 705w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/miR-135a-Atg14-01-450x231.png 450w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/miR-135a-Atg14-01.png 1024w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/a><a href=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/miR-135a-survival.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2117\" src=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/miR-135a-survival-495x400.png\" alt=\"\" width=\"240\" height=\"205\" srcset=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/miR-135a-survival-300x256.png 300w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/miR-135a-survival-768x656.png 768w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/miR-135a-survival-705x602.png 705w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/miR-135a-survival-450x384.png 450w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/miR-135a-survival.png 1024w\" sizes=\"(max-width: 240px) 100vw, 240px\" \/><\/a><\/p>\n<p>\u809d\u764c\u7d30\u80de\u5be6\u9a57\u9032\u4e00\u6b65\u8b49\u5be6\uff0c\u81ea\u566c\u86cb\u767dATG14\u662fmiR-135a\u7684\u76f4\u63a5\u6291\u5236\u6a19\u7684\uff0c\u4e26\u9032\u4e00\u6b65\u4fc3\u9032\u809d\u764c\u7d30\u80de\u7684\u751f\u9577\u8207\u4fb5\u8972\u80fd\u529b\u3002<\/p>\n<p><a href=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/miR-135a-Atg14-02.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2115\" src=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/miR-135a-Atg14-02-495x400.png\" alt=\"\" width=\"400\" height=\"236\" srcset=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/miR-135a-Atg14-02-300x177.png 300w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/miR-135a-Atg14-02-768x453.png 768w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/miR-135a-Atg14-02-705x416.png 705w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/miR-135a-Atg14-02-450x265.png 450w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/miR-135a-Atg14-02.png 777w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/FVII-Autophagy.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2114\" src=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/FVII-Autophagy-495x400.png\" alt=\"\" width=\"400\" height=\"226\" srcset=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/FVII-Autophagy-300x170.png 300w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/FVII-Autophagy-768x434.png 768w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/FVII-Autophagy-705x399.png 705w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/FVII-Autophagy-450x254.png 450w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/FVII-Autophagy.png 1024w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/a><\/p>\n<p><strong>\u51dd\u8840\u56e0\u5b50Factor VII<\/strong><strong>\u5f15\u767c\u4e00\u7cfb\u5217miRNA<\/strong><strong>\u548cmRNA<\/strong><strong>\u57fa\u56e0\u7684\u5dee\u7570\u8868\u9054\uff0c\u5728\u809d\u764c\u7684\u816b\u7624\u7d44\u7e54\u4e2d\u4e3b\u5c0e\u8abf\u7bc0\u764c\u7d30\u80de\u4e0a\u76ae<\/strong><strong>\u2212<\/strong><strong>\u9593\u8cea\u8f49\u5316\u7684\u529f\u80fd\u3002<\/strong><\/p>\n<p>\u6211\u5011\u9032\u4e00\u6b65\u767c\u73fe\u809d\u816b\u7d44\u7e54\u4e2d\uff0c80%\u8207Factor VII\u8868\u9054\u91cf\u76f8\u95dc\u7684miRNAs\u8207\u4e0a\u76ae\u2212\u9593\u8cea\u8f49\u5316\u7684\u529f\u80fd\u6709\u95dc\uff0c\u5176\u4e2d\u768477%(75\/93, \u5305\u62ecmiR-135a)\u8207Factor VII\u8868\u9054\u91cf\u986f\u8457\u6b63\u76f8\u95dc\u3002\u9019\u4e9b\u53ef\u80fd\u53c3\u8207\u4e0a\u76ae\u2212\u9593\u8cea\u8f49\u5316\u904e\u7a0b\u7684\u57fa\u56e0\uff0c\u8207\u7d30\u80de\u7c98\u9644(cell adhesion)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u514d\u75ab\u53cd\u61c9(immune responses)\u7684\u8ca0\u5411\u8abf\u7bc0\u6709\u95dc\u3002<\/p>\n<p><a href=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/DEMs.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2113\" src=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/DEMs-495x400.jpg\" alt=\"\" width=\"450\" height=\"631\" srcset=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/DEMs-214x300.jpg 214w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/DEMs-768x1076.jpg 768w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/DEMs-735x1030.jpg 735w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/DEMs-503x705.jpg 503w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/DEMs-450x631.jpg 450w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/DEMs.jpg 1024w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><\/a><\/p>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-2\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-2\" class=\"tab \"  itemprop=\"headline\" ><span class='tab_icon' aria-hidden='true' data-av_icon='\ue836' data-av_iconfont='entypo-fontello'><\/span>\u5b78\u8853\u8457\u4f5c<\/div>\n    <div id=\"tab-id-2-container\" class=\"tab_content \" aria-hidden=\"true\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<p><strong>Selected recent publications (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Chen%2C+Kuang-Den\" target=\"_blank\" rel=\"noopener\">Pubmed Search<\/a>)<br \/>\n<\/strong> (\u2020 Contributed equally to the article; * Correspondence author of the article)<\/p>\n<p><strong>Chen KD<\/strong>, Huang YH, Wu WS, Chang LS, Chu CL, Kuo HC. <em>Comparable bidirectional neutrophil immune dysregulation between Kawasaki disease and severe COVID-19.<\/em> Frontiers in Immunology, 13:995886 (2022)<\/p>\n<p><strong>Chen KD<\/strong>, Huang YH, Guo MM, Chang LS, Chu CH, Bu LF, Chu CL, Lee CH, Liu SF, Kuo HC*. <em>DNA Methylation Array Identifies Golli-MBP as a Biomarker for Disease Severity in Childhood Atopic Dermatitis.<\/em> Journal of Investigative Dermatology, 142(1):104-113 (2022)<\/p>\n<p><strong>Chen KD<\/strong>, Lin WC, Kuo HC. <em>Chemical and Biochemical Aspects of Molecular Hydrogen in Treating Kawasaki Disease and COVID-19.<\/em> Chemical Research in Toxicology, 34(4):952-958 (2021)<\/p>\n<p><strong>Chen KD<\/strong>, Hsu CN, Wu YJ, Chu CH, Huang KT, Tsai MC, Chiu KW, Cheng BC, Chiu CH, Chen CL, Lin CC. <em>The Perioperatively Altered Neutrophil-to-Lymphocyte Ratio Associates with Impaired DNA Damage Response in Liver Transplantation Recipients with Hepatocellular Carcinoma.<\/em> Diagnostics, 11(2):209 (2021)<\/p>\n<p><strong>Chen KD<\/strong>, Huang YH, Guo MM, Lin TY, Weng WT, Yang HJ, Yang KD, Kuo HC. <em>The human blood DNA methylome identifies crucial role of \u03b2-catenin in the pathogenesis of Kawasaki disease.<\/em> Oncotarget, 9(47):28337-28350 (2018)<\/p>\n<p><strong>Chen KD*<\/strong>, Lin CC, Tsai MC, Huang KT, Chiu KW. <em>Tumor microenvironment mediated by suppression of autophagic flux drives liver malignancy.<\/em> Biomedical Journal, 41(3):163-168 (2018)<\/p>\n<p>Huang KT, Kuo IY, Tsai MC, Wu CH, Hsu LW, Chen LY, Kung CP, Cheng YF, Goto S, Chou YW, Chen CL, Lin CC*, <strong>Chen KD*<\/strong>. <em>Factor VII-Induced MicroRNA-135a Inhibits Autophagy and Is Associated with Poor Prognosis in Hepatocellular Carcinoma.<\/em> Molecular Therapy Nucleic Acids, 9:274-283 (2017)<\/p>\n<p><strong>Chen KD<\/strong>, Huang KT, Tsai MC, Wu CH, Kuo IY, Chen LY, Hu TH, Chen CL, Lin CC. <em>Coagulation factor VII and malignant progression of hepatocellular carcinoma.<\/em> Cell Death &amp; Disease, 7(2):e2110 (2016)<\/p>\n<p><strong>Chen KD<\/strong>, Huang KT, Lin CC, Weng WT, Hsu LW, Goto S, Nakano T, Lai CY, Kung CP, Chiu KW, Wang CC, Cheng YF, Ma YY, Chen CL. <em>MicroRNA-27b Enhances the Hepatic Regenerative Properties of Adipose-Derived Mesenchymal Stem Cells.<\/em> Molecular Therapy Nucleic Acids, 5(2):e285 (2016)<\/p>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-3\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-3\" class=\"tab \"  itemprop=\"headline\" ><span class='tab_icon' aria-hidden='true' data-av_icon='\ue80b' data-av_iconfont='entypo-fontello'><\/span>\u7814\u7a76\u5718\u968a<\/div>\n    <div id=\"tab-id-3-container\" class=\"tab_content \" aria-hidden=\"true\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<h4 style=\"text-align: left;\"><strong>\u00a0<\/strong><\/h4>\n<table width=\"480\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td bgcolor=\"#FFFFFF\">\n<h4 style=\"text-align: center;\"><strong>\u535c\u8389\u9cf3<\/strong><\/h4>\n<h5 style=\"text-align: center;\">\u7814\u7a76\u52a9\u7406<br \/>\nResearch Assistant<\/h5>\n<\/td>\n<td bgcolor=\"#FFFFFF\">\n<h4 style=\"text-align: center;\"><strong>\u51c3\u6021\u5a77<\/strong><\/h4>\n<h5 style=\"text-align: center;\">\u7814\u7a76\u52a9\u7406<br \/>\nResearch Assistant<\/h5>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-4\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-4\" class=\"tab \"  itemprop=\"headline\" ><span class='tab_icon' aria-hidden='true' data-av_icon='\ue840' data-av_iconfont='entypo-fontello'><\/span>\u5b78\u8853\u5c65\u6b77<\/div>\n    <div id=\"tab-id-4-container\" class=\"tab_content \" aria-hidden=\"true\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<p>EDUCATION<\/p>\n<p><strong>Doctor of Philosophy, Life Sciences<\/strong>\u00a0 1991-1997<br \/>\n<em>Institute of Life Science<\/em><br \/>\n<em>National Tsing Hua University, Hsinchu, Taiwan <\/em><\/p>\n<p><strong>Bachelor of Science, Microbiology\u00a0 <\/strong> 1987-1991<br \/>\n<em>Department of Microbiology<\/em><br \/>\n<em>Soochow University, Taipei, Taiwan <\/em><\/p>\n<p>RESEARCH EXPERIENCE<\/p>\n<p><strong>Assistant Research Fellow<\/strong>\u00a0 2009-present<br \/>\n<em>Institute for Translational Research in Biomedicine<\/em><br \/>\n<em>Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan<\/em><\/p>\n<p><strong>Assistant Professor<\/strong>\u00a0 2005-2007<br \/>\n<em>Department of Life Science<\/em><br \/>\n<em>Chang Gung University, Tao-Yuan, Taiwan<\/em><\/p>\n<p><strong>Associate Director<\/strong>\u00a0 2004-2005<br \/>\n<em>Bioinformatics and Information Technology<\/em><br \/>\n<em>Vita Genomics, Inc., Taipei, Taiwan<\/em><\/p>\n<p><strong>Research Fellow\u00a0 <\/strong>2002-2005<br \/>\n<em>Bioinformatics and Information Technology<\/em><br \/>\n<em>Vita Genomics, Inc., Taipei, Taiwan<\/em><\/p>\n<p><strong>Adjunct Assistant Professor<\/strong>\u00a0 2002-2005<br \/>\n<em>Department of Microbiology<\/em><br \/>\n<em>Soochow University, Taipei, Taiwan<\/em><\/p>\n<p><strong>Postdoctoral Fellow<\/strong>\u00a0 2000-2001<br \/>\n<em>Bioengineering Department<\/em><br \/>\n<em>University of California, San Diego, San Diego, USA<\/em><\/p>\n\n        <\/div>\n    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