{"id":2065,"date":"2019-06-27T16:11:23","date_gmt":"2019-06-27T08:11:23","guid":{"rendered":"https:\/\/itrbm.org\/tw\/?page_id=2065"},"modified":"2026-08-28T09:41:24","modified_gmt":"2026-08-28T01:41:24","slug":"peng-jm","status":"publish","type":"page","link":"https:\/\/itrbm.org\/tw\/members\/peng-jm\/","title":{"rendered":"\u5f6d\u745e\u9298 \u526f\u6559\u6388"},"content":{"rendered":"<div id='av_section_1' class='avia-section main_color avia-section-large avia-no-border-styling avia-full-stretch av-section-color-overlay-active avia-bg-style-scroll  avia-builder-el-0  el_before_av_one_fourth  avia-builder-el-first   container_wrap sidebar_left' style='background-repeat: no-repeat; background-image: url(https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/03\/dna-1.jpg);background-attachment: scroll; background-position: center center;  '  data-section-bg-repeat='stretch'><div class='av-section-color-overlay-wrap'><div class='av-section-color-overlay' style='opacity: 0.2; background-color: #000000; '><\/div><div class='container' ><main  role=\"main\" itemprop=\"mainContentOfPage\"  class='template-page content  av-content-small units'><div class='post-entry post-entry-type-page post-entry-2065'><div class='entry-content-wrapper clearfix'>\n<div style='padding-bottom:10px; color:#ffffff;font-size:44px;' class='av-special-heading av-special-heading-h1 custom-color-heading blockquote modern-quote modern-centered  avia-builder-el-1  avia-builder-el-no-sibling  av-inherit-size '><h1 class='av-special-heading-tag '  itemprop=\"headline\"  >\u6210\u54e1\u4ecb\u7d39<\/h1><div class='special-heading-border'><div class='special-heading-inner-border' style='border-color:#ffffff'><\/div><\/div><\/div>\n<\/div><\/div><\/main><!-- close content main element --><\/div><\/div><\/div><div id='after_section_1' class='main_color av_default_container_wrap container_wrap sidebar_left' style=' '  ><div class='container' ><div class='template-page content  av-content-small units'><div class='post-entry post-entry-type-page post-entry-2065'><div class='entry-content-wrapper clearfix'>\n<div class=\"flex_column av_one_fourth  flex_column_div av-zero-column-padding first  avia-builder-el-2  el_after_av_section  el_before_av_one_fourth  avia-builder-el-first  \" style='border-radius:0px; '><div class='avia-image-container  av-styling-    avia-builder-el-3  avia-builder-el-no-sibling  avia-align-left '  itemprop=\"ImageObject\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><img class='avia_image' src='https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2025\/05\/9B2A2567-PengJM_240.jpg' alt='' title='9B2A2567 PengJM 240' height=\"240\" width=\"180\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div><\/div>\n<div class=\"flex_column av_one_fourth  flex_column_div av-zero-column-padding   avia-builder-el-4  el_after_av_one_fourth  el_before_av_one_half  \" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3><strong><span style=\"font-size: 20px; color: #109bc5;\">\u5f6d\u745e\u9298<\/span><\/strong><br \/>\n<span style=\"font-size: 16px; color: #333333;\">\u526f\u6559\u6388<\/span><\/h3>\n<h5><span style=\"color: #333333;\">\u7d30\u80de\u529b\u5b78\u8207\u8a0a\u606f\u50b3\u905e<\/span><br \/>\n<span style=\"color: #333333;\">\u816b\u7624\u751f\u7269\u5b78\u8207\u5fae\u74b0\u5883<\/span><br \/>\n<span style=\"color: #333333;\">\u764c\u75c7\u751f\u7269\u6a19\u8a18\u8207\u6cbb\u7642<\/span><\/h5>\n<\/div><\/section><\/div>\n<div class=\"flex_column av_one_half  flex_column_div av-zero-column-padding   avia-builder-el-6  el_after_av_one_fourth  el_before_av_hr  \" style='border-radius:0px; '><div class='avia-icon-list-container   avia-builder-el-7  avia-builder-el-no-sibling '><ul class='avia-icon-list avia-icon-list-left av-iconlist-small avia_animate_when_almost_visible avia-iconlist-animate'>\n<li><div  style='font-size:14px; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue854' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><div class='av_iconlist_title iconlist_title_small  '  itemprop=\"headline\"   style='font-size:14px; '>\u806f\u7d61\u96fb\u8a71<\/div><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><h5>(07) 731-7123 ext 8597<\/h5>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<li><div  style='font-size:14px; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue805' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><div class='av_iconlist_title iconlist_title_small  '  itemprop=\"headline\"   style='font-size:14px; '>\u96fb\u5b50\u90f5\u4ef6\u4fe1\u7bb1<\/div><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><h5>r.jmpeng@gmail.com<\/h5>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<\/ul><\/div><\/div>\n<div style='height:20px' class='hr hr-invisible   avia-builder-el-8  el_after_av_one_half  el_before_av_tab_container '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div>\n<div class=\"tabcontainer   top_tab   avia-builder-el-9  el_after_av_hr  avia-builder-el-last \">\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-1\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-1\" class=\"tab active_tab\"  itemprop=\"headline\" ><span class='tab_icon' aria-hidden='true' data-av_icon='\ue864' data-av_iconfont='entypo-fontello'><\/span>\u7814\u7a76\u7c21\u4ecb<\/div>\n    <div id=\"tab-id-1-container\" class=\"tab_content active_tab_content\" aria-hidden=\"false\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<h4><strong>VIM <\/strong><strong>\u4fc3\u9032\u816b\u7624\u7684<\/strong><strong> EMT-MET <\/strong><strong>\u8f49\u5316\u548c\u7d30\u80de\u8f49\u79fb<\/strong><\/h4>\n<p>\u4e0a\u76ae\u9593\u8cea\u8f49\u5316 (EMT) \u904e\u7a0b\u662f\u60e1\u6027\u816b\u7624\u767c\u751f\u7684\u91cd\u8981\u539f\u56e0\uff0c\u816b\u7624\u5fae\u74b0\u5883\u5728\u8a98\u5c0e EMT \u904e\u7a0b\u4e2d\u5177\u6709\u91cd\u8981\u7684\u4f5c\u7528\u3002\u5728\u5f62\u614b\u767c\u80b2\u7684\u904e\u7a0b\u4e2d\uff0cEMT \u6700\u521d\u662f\u6307\u4e0a\u76ae\u7ec6\u80de\u8f49\u5316\u70ba\u5177\u8f49\u79fb\u80fd\u529b\u7684\u7ec6\u80de\u3002\u5f8c\u4f86\u7528\u4f86\u63cf\u8ff0\u764c\u7d30\u80de\u5728\u764c\u75c7\u9032\u5c55\u548c\u8f49\u79fb\u904e\u7a0b\u4e2d\u7684\u8f49\u5316\u73fe\u8c61\u3002\u5176\u4e3b\u8981\u7684\u8a0a\u606f\u50b3\u905e\u8def\u5f91\u5305\u62ec TGF-\u03b2\u3001Wnt\u3001Notch\u3001\u751f\u9577\u56e0\u5b50\u63a5\u53d7\u9ad4\u3001\u767c\u708e\u56e0\u5b50\u548c\u7f3a\u6c27\u7b49\uff0c\u5176\u4e2d TGF-\u03b2 \u8abf\u63a7\u8def\u5f91\u88ab\u8a8d\u70ba\u662f EMT \u767c\u751f\u7684\u4e3b\u8981\u539f\u56e0\u3002\u764c\u7d30\u80de\u901a\u5e38\u5728\u767c\u751f EMT \u904e\u7a0b\u5f8c\u8f49\u79fb\uff0c\u5728\u65b0\u7684\u74b0\u5883\u4e2d\u5f62\u6210\u7b2c\u4e8c\u500b\u805a\u843d\u3002\u56e0\u6b64\uff0cEMT \u904e\u7a0b\u5728\u816b\u7624\u8f49\u79fb\u4e2d\u6709\u8457\u4fc3\u9032\u7684\u4f5c\u7528\u3002\u76ee\u524d\u5df2\u77e5\uff0c\u816b\u7624\u5728\u5176\u4fb5\u8972\u6027\u7d30\u80de\u7684\u524d\u7aef\u5c07\u901a\u904e EMT \u8f49\u5316\u70ba\u9593\u8cea\u578b\u7d30\u80de\uff0c\u4f7f\u5176\u8f49\u79fb\u5230\u5468\u570d\u7d44\u7e54\u6216\u8840\u7ba1\u5167\u3002\u7136\u800c\uff0c\u9019\u4e9b\u5728\u524d\u7aef\u5177\u4fb5\u8972\u6027\u7684\u7d30\u80de\u900f\u904e EMT \u8a0a\u606f\u50b3\u905e\u8def\u5f91\u4f86\u5f71\u97ff\u7d30\u80de\u9aa8\u67b6\u91cd\u7d44\u7684\u6a5f\u5236\u5c1a\u672a\u6e05\u695a\u3002\u56e0\u6b64\uff0c\u4e86\u89e3 EMT \u904e\u7a0b\u5728\u9019\u4e9b\u4fb5\u8972\u6027\u7d30\u80de\u4e2d\u7684\u4f5c\u7528\u6a5f\u5236\u5c07\u6709\u5229\u65bc\u85e5\u7269\u958b\u767c\u3002<\/p>\n<p>Vimentin (VIM) \u7570\u5e38\u589e\u52a0\u662f\u764c\u75c7\u60e1\u5316\u7684\u91cd\u8981\u6307\u6a19\u4e4b\u4e00\u3002VIM \u662f\u4e00\u7a2e\u4e2d\u9593\u7d72\u86cb\u767d\uff0c\u662f\u7d30\u80de\u9aa8\u67b6\u86cb\u767d\u7684\u6210\u54e1\u4e4b\u4e00\uff0c\u5728 EMT \u904e\u7a0b\u4e2d\uff0cVIM \u5728\u7d30\u80de\u5f9e\u8cbc\u9644\u8f49\u8b8a\u6210\u79fb\u52d5\u7684\u904e\u7a0b\u4e2d\u626e\u6f14\u8457\u95dc\u9375\u4f5c\u7528\u3002\u76ee\u524d\uff0cVIM \u7684\u8868\u9054\u91cf\u53ef\u80fd\u662f\u80c3\u764c\u60a3\u8005\u9810\u5f8c\u4e0d\u826f\u7684\u6307\u6a19\u4e4b\u4e00\uff0c\u4f46\u5728\u5176\u4ed6\u816b\u7624\u7684\u81e8\u5e8a\u75c5\u7406\u7279\u5fb5\u53ca\u9810\u5f8c\u4ecd\u7136\u5b58\u5728\u722d\u8b70\u3002\u56e0\u6b64\uff0c\u63a2\u8a0e VIM \u5728 EMT \u9032\u5c55\u4e2d\u7684\u529f\u80fd\u53ca\u5176\u6a5f\u5236\uff0c\u53ef\u4ee5\u70ba\u81e8\u5e8a\u764c\u75c7\u8a3a\u65b7\u63d0\u4f9b\u66f4\u6e05\u695a\u7684\u5b9a\u7fa9\u3002<\/p>\n<p><a href=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/EMT.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2068\" src=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/EMT-495x400.jpg\" alt=\"\" width=\"400\" height=\"221\" srcset=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/EMT-300x166.jpg 300w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/EMT-768x425.jpg 768w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/EMT-705x390.jpg 705w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/EMT-450x249.jpg 450w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/EMT.jpg 1024w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/a><\/p>\n<h4><strong>VIM <\/strong><strong>\u8abf\u63a7\u808c\u52d5\u86cb\u767d\u61c9\u529b\u7e96\u7dad\u7684\u5f62\u6210\u548c\u4fb5\u8972\u6027\u524d\u5c0e\u7d30\u80de\u7684\u7d30\u80de\u8cbc\u9644<\/strong><\/h4>\n<p>\u808c\u52d5\u86cb\u767d\u7684\u7d50\u69cb\u548c\u9ecf\u9644\u86cb\u767d (focal adhesion proteins) \u7684\u6392\u5217\u8207\u7d30\u80de\u8f49\u79fb\u6709\u95dc\uff0c\u5229\u7528\u5275\u50b7\u7652\u5408\u5be6\u9a57\uff0c\u6211\u5011\u767c\u73fe\u5c0d\u7167\u7d44\u7d30\u80de\u5b58\u5728\u5927\u91cf\u7684\u808c\u52d5\u86cb\u767d\u61c9\u529b\u7e96\u7dad\u53ca\u9ecf\u9644\u86cb\u767d (Vinculin) \u5728\u7d30\u80de\u5167\u90e8\uff0c\u4f7f\u524d\u5c0e\u7d30\u80de\u904b\u52d5\u9010\u6f38\u8b8a\u6162\u3002\u800c VIM \u7684\u7f3a\u5931\u6703\u5927\u5e45\u6e1b\u5c11\u808c\u52d5\u86cb\u767d\u7684\u61c9\u529b\u7e96\u7dad\u5f62\u6210\uff0c\u4e26\u5c0e\u81f4 Vinculin \u79fb\u4f4d\u5230\u7d30\u80de\u819c\u9031\u908a\uff0c\u9019\u6709\u52a9\u65bc\u7d30\u80de\u5feb\u901f\u524d\u9032\u3002\u5728\u524d\u5c0e\u7d30\u80de\u7f3a\u4e4f VIM \u7684\u60c5\u6cc1\u4e0b\uff0c\u7d30\u80de\u5167\u542b\u8f03\u5c11\u7684\u808c\u52d5\u86cb\u767d\u61c9\u529b\u7e96\u7dad\u548c\u8f03\u591a\u7684 vinculin \u5728\u7d30\u80de\u819c\u9644\u8fd1\uff0c\u9032\u800c\u5927\u5e45\u4fc3\u9032\u7d30\u80de\u7684\u79fb\u52d5\u3002<\/p>\n<p>\u5728\u5275\u50b7\u7652\u5408\u5be6\u9a57\u904e\u7a0b\u4e2d\uff0c\u524d\u5c0e\u7d30\u80de\u6703\u7522\u751f\u9010\u6f38\u7522\u751f\u5927\u91cf\u7684\u7d30\u80de\u5167\u808c\u52d5\u86cb\u767d\u61c9\u529b\u7e96\u7dad\uff0c\u800c VIM \u7684\u7f3a\u5931\u4f7f\u808c\u52d5\u86cb\u767d\u61c9\u529b\u7e96\u7dad\u660e\u986f\u6e1b\u5c11\u3002\u5728\u7d30\u80de\u79fb\u52d5\u904e\u7a0b\u4e2d\u96a8\u8457\u808c\u52d5\u86cb\u767d\u5f62\u6210\u7d30\u7d72\uff0cVIM \u7684\u8868\u73fe\u4e5f\u6703\u9010\u6f38\u589e\u52a0\uff0c\u4e26\u4fc3\u9032\u808c\u52d5\u86cb\u767d\u7d72\u7d50\u5408\u5f62\u6210\u7e96\u7dad\u675f\u800c\u7522\u751f\u5f37\u6709\u529b\u7684\u7d50\u69cb\u3002TGF-\u03b2\u00a0\u7684\u523a\u6fc0\u6703\u4fc3\u9032 VIM \u7684\u8868\u73fe\uff0c\u800c\u6291\u5236 TGF-B \u53ef\u4ee5\u6e1b\u5c11 VIM \u7684\u7522\u751f\u3002\u5728\u514d\u75ab\u7d30\u80de\u8fa8\u8b58\u548c\u653b\u64ca\u764c\u7d30\u80de\u7684\u904e\u7a0b\u4e2d\uff0c\u963b\u65b7 TGF-\u03b2 \u7684\u4f5c\u7528\u6703\u5354\u540c\u589e\u5f3a\u6297 PD-L1 \u6297\u9ad4\u4fc3\u9032\u514d\u75ab\u7d30\u80de\u6d78\u6f64\u7684\u6cbb\u7642\u6548\u679c\uff0c\u56e0\u800c EMT-MET \u8f49\u5316\u904e\u7a0b\u5728\u514d\u75ab\u7d30\u80de\u904b\u4f5c\u6642\u4ea6\u626e\u6f14\u91cd\u8981\u7684\u5f71\u97ff\uff0c\u63a2\u8a0e\u5176\u4f5c\u7528\u6a5f\u5236\u5c07\u6709\u52a9\u65bc\u816b\u7624\u514d\u75ab\u6cbb\u7642\u7684\u61c9\u7528\u3002<\/p>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-2\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-2\" class=\"tab \"  itemprop=\"headline\" ><span class='tab_icon' aria-hidden='true' data-av_icon='\ue836' data-av_iconfont='entypo-fontello'><\/span>\u5b78\u8853\u8457\u4f5c<\/div>\n    <div id=\"tab-id-2-container\" class=\"tab_content \" aria-hidden=\"true\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<p><strong>Selected recent publications (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Peng%2C+Jei-Ming\" target=\"_blank\" rel=\"noopener\">Pubmed Search<\/a>)<br \/>\n<\/strong> (\u2020 Contributed equally to the article; * Correspondence author of the article)<\/p>\n<p>Chang YL, Luo HL, <strong>Peng JM*<\/strong>, Hsiao CC*. <em>Pre-Treatment BOC Expression as an Indicator of Lymphovascular Invasion and Chemotherapeutic Response in Upper Tract Urothelial Carcinoma.<\/em> Oncology Research, 34(4):19 (2026)<\/p>\n<p><strong>Peng JM<\/strong>, Liu HY. <em>CD300a: An Innate Immune Checkpoint Shaping Tumor Immunity and Therapeutic Opportunity.<\/em> Cancers, 17(11):1786 (2025)<\/p>\n<p><strong>Peng JM*<\/strong>, Su YL*. <em>Lymph node metastasis and tumor-educated immune tolerance: Potential therapeutic targets against distant metastasis.<\/em> Biochemical Pharmacology, 215:115731 (2023)<\/p>\n<p><strong>Peng JM<\/strong>, Chiu CF, Cheng JH, Liu HY, Chang YL, Luo JW, Weng YT, Luo HL. <em>Evasion of NK cell immune surveillance via the vimentin-mediated cytoskeleton remodeling.<\/em> Frontiers in Immunology, 13:883178 (2022)<\/p>\n<p><strong>Peng JM<\/strong>, Chen WY, Cheng JH, Luo JW, Tzeng HT. <em>Dysregulation of Cytoskeleton Remodeling Drives Invasive Leading Cells Detachment.<\/em> Cancers, 13(22):5648 (2021)<\/p>\n<p><strong>Peng JM<\/strong>, Hsieh SY, Cheng JH, Luo JW, Su YL, Luo HL. <em>Confirming whether KLHL23 deficiency potentiates migration in urothelial carcinoma.<\/em> Chinese Journal of Physiology, 64(3):142-149 (2021)<\/p>\n<p><strong>Peng JM<\/strong>, Lin SH, Yu MC, Hsieh SY. <em>CLIC1 recruits PIP5K1A\/C to induce cell-matrix adhesions for tumor metastasis.<\/em> Journal of Clinical Investigation, 131(1):e133525 (2021)<\/p>\n<p><strong>Peng JM<\/strong>, Tseng RH, Shih TC, Hsieh SY*. <em>CAMK2N1 suppresses hepatoma growth through inhibiting E2F1-mediated cell-cycle signaling.<\/em> Cancer Letters, 497:66-76 (2020)<\/p>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-3\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-3\" class=\"tab \"  itemprop=\"headline\" ><span class='tab_icon' aria-hidden='true' data-av_icon='\ue80b' data-av_iconfont='entypo-fontello'><\/span>\u7814\u7a76\u5718\u968a<\/div>\n    <div id=\"tab-id-3-container\" class=\"tab_content \" aria-hidden=\"true\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<h4 style=\"text-align: left;\"><strong>\u00a0<\/strong><\/h4>\n<table width=\"240\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td bgcolor=\"#FFFFFF\">\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2069 size-full\" src=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/LoCW240.jpg\" alt=\"\" width=\"180\" height=\"240\" \/><\/p>\n<h4 style=\"text-align: center;\"><strong>\u7f85\u4f73\u7d0b<\/strong><\/h4>\n<h5 style=\"text-align: center;\">\u7814\u7a76\u52a9\u7406<br \/>\nResearch Assistant<\/h5>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-4\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-4\" class=\"tab \"  itemprop=\"headline\" ><span class='tab_icon' aria-hidden='true' data-av_icon='\ue840' data-av_iconfont='entypo-fontello'><\/span>\u5b78\u8853\u5c65\u6b77<\/div>\n    <div id=\"tab-id-4-container\" class=\"tab_content \" aria-hidden=\"true\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<p><strong>EDUCATION:<\/strong><\/p>\n<p>2004 &#8211; 2011 Ph.D.<br \/>\nInstitute of Biochemical Sciences,<br \/>\nNational Taiwan University, Taiwan<\/p>\n<p>1998 &#8211; 2000 M.S.<br \/>\nInstitute of Microbiology,<br \/>\nNational Taiwan University, Taiwan<\/p>\n<p><strong>PROFESSIONAL EXPERIENCE:<\/strong><\/p>\n<p>2018\/8 ~ present\u00a0 <strong>Assistant Professor<\/strong><br \/>\nInstitute for Translational Research in Biomedicine,<br \/>\nKaohsiung Chang Gung Memorial Hospital,<br \/>\nKaohsiung, Taiwan<\/p>\n<p>2012\/5 ~ 2018\/7\u00a0 <strong>Postdoctoral Research Fellow<\/strong><br \/>\nLiver Research Unit,<br \/>\nChang Gung Memorial Hospital, Linko, Taiwan<\/p>\n<p><strong>AWARDS:<\/strong><\/p>\n<p>2009\u00a0 The award of excellent poster, the 24th Joint Annual Conference of Biomedical Sciences, The Taiwan Society of Biochemistry and Molecular Biology.<br \/>\n2006\u00a0 Best student in the Ph.D. poster competition, Institute of Biochemical Sciences, National Taiwan University, Taiwan.<br \/>\n2005\u00a0 The award of outstanding research, Institute of Biochemical Sciences, National Taiwan University, Taiwan.<br \/>\n2004\u00a0 The award of outstanding research, Jung-Yaw Lin Foundation, Taiwan.<\/p>\n<p><strong>RESEARCH INTERESTS:<\/strong><\/p>\n<p>\u2022 Molecular mechanisms of cell cytoskeleton<br \/>\n\u2022 Discovery of cancer biomarkers<br \/>\n\u2022 Tumor microenvironment<br \/>\n\u2022 Prevention and therapy of cancer: preclinical study<\/p>\n<p><strong>PUBLICATION LIST:<\/strong><\/p>\n<p>1. Peng JM, Bera R, Chiou CY, Yu MC, Chen TC, Chen CW, Wang TR, Chiang WL, Chai SP, Wei Y, Wang H, Hung MC, Hsieh SY. Actin cytoskeleton remodeling drives epithelial-mesenchymal transition for hepatoma invasion and metastasis in mice. Hepatology, 67(6): 2226-2243 (2018)<\/p>\n<p>2. Bera R, Chiou CY, Yu MC, Peng JM, He CR, Hsu CY, Huang HL, Ho UY, Lin SM, Lin YJ, Hsieh SY. Functional genomics identified a novel protein tyrosine phosphatase receptor type F-mediated growth inhibition in hepatocarcinogenesis. Hepatology, 59(6): 2238-2250 (2014)<\/p>\n<p>3. Chiu CF, Ho MY, Peng JM, Hung SW, Lee WH, Liang CM, Liang SM. Raf activation by Ras and promotion of cellular metastasis require phosphorylation of prohibitin in the raft domain of the plasma membrane. Oncogene, 32(6): 777-787 (2013)<\/p>\n<p>4. Peng JM, Chen YH, Hung SW, Chiu CF, Ho MY, Lee YJ, Lai TC, Hsiao M, Liang CM, Liang SM. Recombinant viral protein promotes apoptosis and suppresses invasion of ovarian adenocarcinoma cells by targeting alpha5beta1 integrin to down-regulate Akt and MMP-2. British Journal of Pharmacology, 165(2): 479-493 (2012)<\/p>\n<p>5. Chiu CF, Peng JM, Hung SW, Liang CM, Liang SM. Recombinant viral capsid protein VP1 suppresses migration and invasion of human cervical cancer by modulating phosphorylated prohibitin in lipid rafts. Cancer letters, 320(2): 205-214 (2012)<\/p>\n<p>6. Huang CY, Liang CM, Chu CL, Peng JM, Liang SM. A fibrillar form of fibronectin induces apoptosis by activating SHP-2 and stress fiber formation. Apoptosis, 15(8): 915-926 (2010)<\/p>\n<p>7. Peng JM, Liang SM, Liang CM. VP1 of foot-and-mouth disease virus induces apoptosis via the Akt signaling pathway. Journal of Biological Chemistry, 279(50): 52168-52174 (2004)<\/p>\n<p>8. Wang JH, Liang CM, Peng JM, Shieh JJ, Jong MH, Lin YL, Sieber M, Liang SM. Induction of immunity in swine by purified recombinant VP1 of foot-and-mouth disease virus. Vaccine, 21(25-26): 3721-3729 (2003)<\/p>\n<p>9. Lin YC, Peng JM, Wang WB. The N-terminal common domain of simian virus 40 large T and small t antigens acts as a transformation suppressor of the HER-2\/neu oncogene. Oncogene, 19(22): 2704-2713 (2000)<\/p>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":443,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/itrbm.org\/tw\/wp-json\/wp\/v2\/pages\/2065"}],"collection":[{"href":"https:\/\/itrbm.org\/tw\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/itrbm.org\/tw\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/itrbm.org\/tw\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/itrbm.org\/tw\/wp-json\/wp\/v2\/comments?post=2065"}],"version-history":[{"count":13,"href":"https:\/\/itrbm.org\/tw\/wp-json\/wp\/v2\/pages\/2065\/revisions"}],"predecessor-version":[{"id":4891,"href":"https:\/\/itrbm.org\/tw\/wp-json\/wp\/v2\/pages\/2065\/revisions\/4891"}],"up":[{"embeddable":true,"href":"https:\/\/itrbm.org\/tw\/wp-json\/wp\/v2\/pages\/443"}],"wp:attachment":[{"href":"https:\/\/itrbm.org\/tw\/wp-json\/wp\/v2\/media?parent=2065"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}