{"id":1940,"date":"2019-06-20T22:19:58","date_gmt":"2019-06-20T14:19:58","guid":{"rendered":"https:\/\/itrbm.org\/tw\/?page_id=1940"},"modified":"2025-06-30T16:46:23","modified_gmt":"2025-06-30T08:46:23","slug":"tsai-cy","status":"publish","type":"page","link":"https:\/\/itrbm.org\/tw\/members\/tsai-cy\/","title":{"rendered":"\u8521\u975c\u5b9c \u526f\u6559\u6388"},"content":{"rendered":"<div id='av_section_1' class='avia-section main_color avia-section-large avia-no-border-styling avia-full-stretch av-section-color-overlay-active avia-bg-style-scroll  avia-builder-el-0  el_before_av_one_fourth  avia-builder-el-first   container_wrap sidebar_left' style='background-repeat: no-repeat; background-image: url(https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/03\/dna-1.jpg);background-attachment: scroll; background-position: center center;  '  data-section-bg-repeat='stretch'><div class='av-section-color-overlay-wrap'><div class='av-section-color-overlay' style='opacity: 0.2; background-color: #000000; '><\/div><div class='container' ><main  role=\"main\" itemprop=\"mainContentOfPage\"  class='template-page content  av-content-small units'><div class='post-entry post-entry-type-page post-entry-1940'><div class='entry-content-wrapper clearfix'>\n<div style='padding-bottom:10px; color:#ffffff;font-size:44px;' class='av-special-heading av-special-heading-h1 custom-color-heading blockquote modern-quote modern-centered  avia-builder-el-1  avia-builder-el-no-sibling  av-inherit-size '><h1 class='av-special-heading-tag '  itemprop=\"headline\"  >\u6210\u54e1\u4ecb\u7d39<\/h1><div class='special-heading-border'><div class='special-heading-inner-border' style='border-color:#ffffff'><\/div><\/div><\/div>\n<\/div><\/div><\/main><!-- close content main element --><\/div><\/div><\/div><div id='after_section_1' class='main_color av_default_container_wrap container_wrap sidebar_left' style=' '  ><div class='container' ><div class='template-page content  av-content-small units'><div class='post-entry post-entry-type-page post-entry-1940'><div class='entry-content-wrapper clearfix'>\n<div class=\"flex_column av_one_fourth  flex_column_div av-zero-column-padding first  avia-builder-el-2  el_after_av_section  el_before_av_one_fourth  avia-builder-el-first  \" style='border-radius:0px; '><div class='avia-image-container  av-styling-    avia-builder-el-3  avia-builder-el-no-sibling  avia-align-left '  itemprop=\"ImageObject\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><img class='avia_image' src='https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2025\/05\/9B2A2561-TsaiCY_240.jpg' alt='' title='9B2A2561 TsaiCY 240' height=\"240\" width=\"180\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div><\/div>\n<div class=\"flex_column av_one_fourth  flex_column_div av-zero-column-padding   avia-builder-el-4  el_after_av_one_fourth  el_before_av_one_half  \" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3><strong><span style=\"font-size: 20px; color: #109bc5;\">\u8521\u975c\u5b9c<\/span><\/strong><br \/>\n<span style=\"font-size: 16px; color: #333333;\">\u526f\u6559\u6388<\/span><\/h3>\n<h5><span style=\"color: #333333;\">\u4e2d\u6a1e\u5fc3\u8840\u7ba1\u8abf\u63a7<\/span><br \/>\n<span style=\"color: #333333;\">\u8a0a\u606f\u50b3\u905e<\/span><br \/>\n<span style=\"color: #333333;\">\u5206\u5b50\u5f71\u50cf<\/span><br \/>\n<span style=\"color: #333333;\">\u6bba\u87f2\u5291\u3001\u9ebb\u9189\u5291\u4e4b\u85e5\u7406\u5b78<\/span><br \/>\n<span style=\"color: #333333;\">\u6c27\u5316\u9084\u539f\u8a0a\u606f\u8207\u6c27\u5316\u58d3\u529b<\/span><\/h5>\n<\/div><\/section><\/div>\n<div class=\"flex_column av_one_half  flex_column_div av-zero-column-padding   avia-builder-el-6  el_after_av_one_fourth  el_before_av_hr  \" style='border-radius:0px; '><div class='avia-icon-list-container   avia-builder-el-7  avia-builder-el-no-sibling '><ul class='avia-icon-list avia-icon-list-left av-iconlist-small avia_animate_when_almost_visible avia-iconlist-animate'>\n<li><div  style='font-size:14px; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue854' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><div class='av_iconlist_title iconlist_title_small  '  itemprop=\"headline\"   style='font-size:14px; '>\u806f\u7d61\u96fb\u8a71<\/div><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><h5>(07) 731-7123 ext 8598<\/h5>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<li><div  style='font-size:14px; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue805' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><div class='av_iconlist_title iconlist_title_small  '  itemprop=\"headline\"   style='font-size:14px; '>\u96fb\u5b50\u90f5\u4ef6\u4fe1\u7bb1<\/div><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><h5>cytsai@cgmh.org.tw<\/h5>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<\/ul><\/div><\/div>\n<div style='height:20px' class='hr hr-invisible   avia-builder-el-8  el_after_av_one_half  el_before_av_tab_container '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div>\n<div class=\"tabcontainer   top_tab   avia-builder-el-9  el_after_av_hr  avia-builder-el-last \">\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-1\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-1\" class=\"tab active_tab\"  itemprop=\"headline\" ><span class='tab_icon' aria-hidden='true' data-av_icon='\ue864' data-av_iconfont='entypo-fontello'><\/span>\u7814\u7a76\u7c21\u4ecb<\/div>\n    <div id=\"tab-id-1-container\" class=\"tab_content active_tab_content\" aria-hidden=\"false\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<h4><strong>\u7814\u7a76\u4e3b\u8ef8: \u89e3\u958b\u8166\u5e79\u8abf\u7bc0\u5fc3\u8840\u7ba1\u529f\u80fd\u5728\u5065\u5eb7\u548c\u75be\u75c5\u6a21\u578b\u4e2d\u7684\u7d30\u80de\u548c\u5206\u5b50\u6a5f\u5236<\/strong><\/h4>\n<p>\u672c\u5be6\u9a57\u5ba4\u7684\u7814\u7a76\u805a\u7126\u65bc\u8166\u5e79\u6b7b\u4ea1 (brainstem death)\uff0c\u795e\u7d93\u6e90\u6027\u9ad8\u8840\u58d3 (neurogenic hypertension) \u548c\u809d\u6027\u8166\u75c5\u8b8a (hepatic encephalopathy) \u7b49\u75be\u75c5\u6a21\u5f0f\u8166\u5e79\u5fc3\u8840\u7ba1\u8abf\u63a7\u4e2d\u6240\u6d89\u53ca\u7684\u8a0a\u606f\u50b3\u905e\u8def\u5f91\u548c\u795e\u7d93\u8ff4\u8def\u63a2\u8a0e\u3002\u6211\u5011\u7684\u7814\u7a76\u662f\u4f7f\u7528\u81e8\u5e8a\u76f8\u95dc\u7684\u52d5\u7269\u6a21\u578b\uff0c\u4e26\u5c07\u7d30\u80de\u548c\u5206\u5b50\u751f\u7269\u5b78\u6574\u5408\u5230\u7cfb\u7d71\u751f\u7406\u5b78\u4e2d\u4f86\u9032\u884c\u3002\u8fd1\u5e74\u4f86\uff0c\u6211\u5011\u4ea6\u5c07\u8166\u5e79\u5fc3\u8840\u7ba1\u8abf\u7bc0\u7684\u7814\u7a76\u8996\u91ce\u64f4\u5c55\u5230\u611f\u58d3\u53cd\u5c04\u795e\u7d93\u8ff4\u8def\u4e2d\u6240\u6d89\u53ca\u5230\u7684\u8166\u5e79\u6838\u5340\u4e4b\u9593\u529f\u80fd\u6027\u9023\u7d50\u7684\u5716\u50cf\u8b8a\u5316\uff0c\u4e26\u8868\u660e\u9019\u4e9b\u8b8a\u5316\u5177\u6709\u751f\u7406\u5b78\u548c\u75c5\u7406\u5b78\u4e0a\u7684\u610f\u7fa9\u3002<\/p>\n<h5><strong>1. \u63d0\u51fa\u5ef6\u8166\u8179\u5916\u5074\u6838 (RVLM) \u5728\u6709\u6a5f\u78f7\u7f8e\u6587\u677e\u4e2d\u6bd2\u5f15\u8d77\u7684\u8166\u5e79\u6b7b\u4ea1\u6a21\u578b\u4e2d\u7684\u7d30\u80de\u5206\u5b50\u6a5f\u5236\u3002<\/strong><\/h5>\n<p>\u6211\u5011\u7684\u7814\u7a76\u767c\u73feRVLM\u5167PI3K\/Akt\u8a0a\u606f\u8def\u5f91\u6d3b\u5316\u6703\u5c0e\u81f4NF-\u03baB\/NOS II\/peroxynitrite\u8def\u5f91\u9032\u4e00\u6b65\u6d3b\u5316\u4e26\u9020\u6210\u8166\u5e79\u5fc3\u8840\u7ba1\u8abf\u63a7\u5931\u80fd\u3002FLJ10540\u70baPI3K\u7d50\u5408\u86cb\u767d\uff0c\u53ef\u4ee5\u4fc3\u9032PI3K\/Akt\u8a0a\u606f\u50b3\u905e\u8def\u5f91\u5f15\u8d77\u5fc3\u8840\u7ba1\u8abf\u63a7\u5931\u80fd\u3002\u53e6\u4e00\u65b9\u9762\uff0cPTEN\u53ef\u4ee5\u900f\u904e\u6e1b\u5c11\u672c\u8eab\u7684\u6c27\u5316\u614b\u4f86\u589e\u9032\u6d3b\u6027\uff0c\u4e26\u626e\u6f14PI3K\/Akt\u8a0a\u606f\u8def\u5f91\u7684\u8ca0\u8abf\u63a7\u8005\u4f86\u6291\u5236\u4e0b\u6e38\u7684NOS II\/peroxynitrite\u8def\u5f91\uff0c\u9032\u800c\u6e1b\u7de9\u5fc3\u8840\u7ba1\u8abf\u63a7\u5931\u80fd\u3002(<em>Biochem Pharmacol.<\/em> 2018 Sep; 155:207-212.)<\/p>\n<p><a href=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/FLJ10540.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1950\" src=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/FLJ10540.jpg\" alt=\"\" width=\"500\" height=\"144\" srcset=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/FLJ10540.jpg 2213w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/FLJ10540-300x86.jpg 300w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/FLJ10540-768x221.jpg 768w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/FLJ10540-1030x296.jpg 1030w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/FLJ10540-1500x431.jpg 1500w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/FLJ10540-705x203.jpg 705w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/FLJ10540-450x129.jpg 450w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/a><\/p>\n<h5><strong>2. \u6211\u5011\u9084\u5c07\u5206\u5b50\u5f71\u50cf\u8207\u8166\u5e79\u5fc3\u8840\u7ba1\u8abf\u7bc0\u7684\u751f\u7406\u8a55\u4f30\u76f8\u7d50\u5408\uff0c\u4f7f\u7528\u78c1\u632f\u64f4\u6563\u5f35\u91cf\u5f71\u50cf (DTI) \u4f86\u6aa2\u6e2c\u611f\u58d3\u53cd\u5c04\u795e\u7d93\u8ff4\u8def\u4e2d\u6d89\u53ca\u7684\u8166\u5e79\u6838\u5340\u4e4b\u9593\u7684\u529f\u80fd\u6027\u9023\u7d50\u8b8a\u5316\u3002 <\/strong><\/h5>\n<p>\u5728\u75c5\u7406\u751f\u7406\u689d\u4ef6\u4e0b (\u4f8b\u5982\u795e\u7d93\u6e90\u6027\u9ad8\u8840\u58d3)\uff0c\u6b64\u795e\u7d93\u8ff4\u8def\u9023\u7d50\u4e2d\u65b7\uff0c\u7522\u751f\u9ad8\u8840\u58d3\u3002\u7576\u795e\u7d93\u9023\u7d50\u4e2d\u65b7\u53ef\u9006\u8f49\uff0c\u8840\u58d3\u56de\u5fa9\u6b63\u5e38\u503c\uff0c\u4ee3\u8868\u6b64\u75be\u75c5\u6a21\u5f0f\u53ef\u4ee5\u88ab\u6cbb\u7642\u3002\u7136\u800c\uff0c\u7576\u75c5\u7406\u751f\u7406\u72c0\u6cc1\u6f14\u8b8a\u70ba\u75c5\u7406\u72c0\u614b\u6642 (\u4f8b\u5982\u809d\u6027\u8166\u75c5\u8b8a)\uff0c\u6b64\u795e\u7d93\u9023\u7d50\u4e2d\u65b7\u4e0d\u53ef\u9006\u8f49\uff0c\u6700\u5f8c\u52d5\u7269\u6b7b\u4ea1\uff0c\u4ee3\u8868\u6b64\u75be\u75c5\u6a21\u5f0f\u4e0d\u53ef\u4ee5\u88ab\u6cbb\u7642\u3002(<em>J Physiol.<\/em> 2019 Jan; 597(1):41-55.)<\/p>\n<p><a href=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/DTI.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1949\" src=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/DTI.jpg\" alt=\"\" width=\"450\" height=\"296\" srcset=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/DTI.jpg 922w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/DTI-300x197.jpg 300w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/DTI-768x505.jpg 768w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/DTI-705x463.jpg 705w, https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/DTI-450x296.jpg 450w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><\/a><\/p>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-2\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-2\" class=\"tab \"  itemprop=\"headline\" ><span class='tab_icon' aria-hidden='true' data-av_icon='\ue836' data-av_iconfont='entypo-fontello'><\/span>\u5b78\u8853\u8457\u4f5c<\/div>\n    <div id=\"tab-id-2-container\" class=\"tab_content \" aria-hidden=\"true\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<p><strong>Recent publications (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Ching-Yi+Tsai&#091;author&#093;\" target=\"_blank\" rel=\"noopener\">Pubmed Search<\/a>)<\/strong><\/p>\n<p>1: Hung YY, Tsai CY, Lee CT, Fu HC, Chou CK, Yang YC, Chen JF, Kang HY. Targeting TNIP1 as a new therapeutic avenue for major depressive disorder. Brain Behav Immun. 2025 May;126:214-224. doi: 10.1016\/j.bbi.2025.02.015. Epub 2025 Feb 18. PMID: 39978697.<\/p>\n<p>2: Yu HR, Tsai CY, Chen WL, Liu PY, Tain YL, Sheen JM, Huang YS, Tiao MM, Chiu CY. Exploring Oxidative Stress and Metabolic Dysregulation in Lung Tissues of Offspring Rats Exposed to Prenatal Polystyrene Microplastics: Effects of Melatonin Treatment. Antioxidants (Basel). 2024 Nov 28;13(12):1459. doi: 10.3390\/antiox13121459. PMID: 39765788; PMCID: PMC11672973.<\/p>\n<p>3: Tsai CY, Lee CL, Wu JCC. Astrocyte-secreted lipocalin-2 elicits bioenergetic failure-induced neuronal death that is causally related to high fatality in a mouse model of hepatic encephalopathy. Neurochem Int. 2024 Sep;178:105800. doi: 10.1016\/j.neuint.2024.105800. Epub 2024 Jul 2. PMID: 38964718.<\/p>\n<p>4: Thangudu S, Tsai CY, Lin WC, Su CH. Modified gefitinib conjugated Fe<sub>3<\/sub>O<sub>4<\/sub> NPs for improved delivery of chemo drugs following an image-guided mechanistic study of inner vs. outer tumor uptake for the treatment of non-small cell lung cancer. Front Bioeng Biotechnol. 2023 Oct 9;11:1272492. doi: 10.3389\/fbioe.2023.1272492. PMID: 37877039; PMCID: PMC10591449.<\/p>\n<p>5: Tsai CY, Wu JCC, Wu CJ, Chan SHH. Protective role of VEGF\/VEGFR2 signaling against high fatality associated with hepatic encephalopathy via sustaining mitochondrial bioenergetics functions. J Biomed Sci. 2022 Jul 3;29(1):47. doi: 10.1186\/s12929-022-00831-0. PMID: 35786324; PMCID: PMC9251935.<\/p>\n<p>6: Tsai CY, Fang C, Wu JCC, Wu CJ, Dai KY, Chen SM. Neuroinflammation and Microglial Activation at Rostral Ventrolateral Medulla Underpin Cadmium-Induced Cardiovascular Dysregulation in Rats. J Inflamm Res. 2021 Aug 11;14:3863-3877. doi: 10.2147\/JIR.S325528. PMID: 34408468; PMCID: PMC8364915.<\/p>\n<p>7: Poon YY, Liu YW, Huang YH, Chan SHH, Tsai CY. Postoperative Stroke after Spinal Anesthesia and Responses of Carotid or Cerebral Blood Flow and Baroreflex Functionality to Spinal Bupivacaine in Rats. Biology (Basel). 2021 Jul 2;10(7):617. doi: 10.3390\/biology10070617. PMID: 34356472; PMCID: PMC8301092.<\/p>\n<p>8: Poon YY, Tsai CY, Huang YH, Wu JCC, Chan SHH, Chan JYH. Disproportional cardiovascular depressive effects of isoflurane: Serendipitous findings from a comprehensive re-visit in mice. Lab Anim (NY). 2021 Jan;50(1):26-31. doi: 10.1038\/s41684-020-00684-w. Epub 2020 Nov 30. PMID: 33257894.<\/p>\n<p>9: Tsai CY, Wu CJ, Wu JCC, Fang C, Huang YH, Dai KY. Redox-active DJ-1 sustains brainstem cardiovascular regulation via maintenance of mitochondrial function during mevinphos intoxication. Neurochem Int. 2020 Oct;139:104791. doi: 10.1016\/j.neuint.2020.104791. Epub 2020 Jul 8. PMID: 32650030.<\/p>\n<p>10: Tsai CY, Wu JCC, Chen SM, Lin HH, Chan JYH, Chan SHH. Physiological and pathophysiological evaluation of baroreflex functionality with concurrent diffusion tensor imaging of its neural circuit in the rat. Biomed J. 2019 Dec;42(6):381-393. doi: 10.1016\/j.bj.2019.10.006. Epub 2019 Dec 24. PMID: 31948602; PMCID: PMC6962742.<\/p>\n<p>11: Chen SM, Phuagkhaopong S, Fang C, Wu JCC, Huang YH, Vivithanaporn P, Lin HH, Tsai CY. Dose-Dependent Acute Circulatory Fates Elicited by Cadmium Are Mediated by Differential Engagements of Cardiovascular Regulatory Mechanisms in Brain. Front Physiol. 2019 Jun 18;10:772. doi: 10.3389\/fphys.2019.00772. PMID: 31275174; PMCID: PMC6591476.<\/p>\n<p>12: Mukda S, Tsai CY, Leu S, Yang JL, Chan SHH. Pinin protects astrocytes from cell death after acute ischemic stroke via maintenance of mitochondrial anti-apoptotic and bioenergetics functions. J Biomed Sci. 2019 Jun 5;26(1):43. doi: 10.1186\/s12929-019-0538-5. PMID: 31167655; PMCID: PMC6549339.<\/p>\n<p>13: Tsai CY, Poon YY, Huang YH, Chan SH. Activation of spinal nociceptin receptors induces cardiovascular depression and antinociception in an independent manner in mice. J Pain Res. 2018 Nov 1;11:2699-2708. doi: 10.2147\/JPR.S175259. PMID: 30464587; PMCID: PMC6219425.<\/p>\n<p>14: Tsai CY, Poon YY, Chan JYH, Chan SHH. Baroreflex functionality in the eye of diffusion tensor imaging. J Physiol. 2019 Jan;597(1):41-55. doi: 10.1113\/JP277008. Epub 2018 Nov 2. PMID: 30325020; PMCID: PMC6312450.<\/p>\n<p>15: Tsai CY, Dai KY, Fang C, Wu JCC, Chan SHH. PTEN\/FLJ10540\/PI3K\/Akt cascade in experimental brain stem death: A newfound role for a classical tumorigenic signaling pathway. Biochem Pharmacol. 2018 Sep;155:207-212. doi: 10.1016\/j.bcp.2018.07.002. Epub 2018 Jul 3. PMID: 30008438.<\/p>\n<p>16: Tsai CY, Poon YY, Chen CH, Chan SHH. Anomalous baroreflex functionality inherent in floxed and Cre-Lox mice: an overlooked physiological phenotype. Am J Physiol Heart Circ Physiol. 2017 Oct 1;313(4):H700-H707. doi: 10.1152\/ajpheart.00346.2017. Epub 2017 Aug 4. PMID: 28778914.<\/p>\n<p>17: Tsai CY, Wu JCC, Fang C, Chang AYW. PTEN, a negative regulator of PI3K\/Akt signaling, sustains brain stem\u00a0cardiovascular regulation during mevinphos intoxication. Neuropharmacology. 2017 Sep 1;123:175-185. doi: 10.1016\/j.neuropharm.2017.06.007. Epub 2017 Jun 7. PMID: 28601397.<\/p>\n<p>18: Tsai CY, Su CH, Chan JY, Chan SH. Nitrosative Stress-Induced Disruption of Baroreflex Neural Circuits in a Rat Model of Hepatic Encephalopathy: A DTI Study. Sci Rep. 2017 Jan 12;7:40111. doi: 10.1038\/srep40111. PMID: 28079146; PMCID: PMC5228038.<\/p>\n<p>19: Tsai CY, Li FC, Wu CH, Chang AY, Chan SH. Sumoylation of IkB attenuates NF-kB-induced nitrosative stress at rostral entrolateral medulla and cardiovascular depression in experimental brain death. J Biomed Sci. 2016 Sep 22;23(1):65. doi: 10.1186\/s12929-016-0283-y. PMID: 27658615; PMCID: PMC5034413.<\/p>\n<p>20: Poon YY, Tsai CY, Cheng CD, Chang AY, Chan SH. Endogenous nitric oxide derived from NOS I or II in thoracic spinal cord exerts opposing tonic modulation on sympathetic vasomotor tone via disparate mechanisms in anesthetized rats. Am J Physiol Heart Circ Physiol. 2016 Sep 1;311(3):H555-62. doi: 10.1152\/ajpheart.00246.2016. Epub 2016 Jul 1. PMID: 27371683.<\/p>\n<p>21: Su CH, Tsai CY, Chang AY, Chan JY, Chan SH. MRI\/DTI of the Brain Stem Reveals Reversible and Irreversible Disruption of the Baroreflex Neural Circuits: Clinical Implications. Theranostics. 2016 Apr 11;6(6):837-48. doi: 10.7150\/thno.14837. PMID: 27162554; PMCID: PMC4860892.<\/p>\n<p>22: Su CH, Tsai CY, Tomanek B, Chen WY, Cheng FY. Evaluation of blood-brain barrier-stealth nanocomposites for in situ glioblastoma theranostics applications. Nanoscale. 2016 Apr 21;8(15):7866-70. doi: 10.1039\/c6nr00280c. PMID: 27035391.<\/p>\n<p>23: Hsieh MC, Tsai CY, Liao MC, Yang JL, Su CH, Chen JH. Quantitative Susceptibility Mapping-Based Microscopy of Magnetic Resonance Venography (QSM-mMRV) for In Vivo Morphologically and Functionally Assessing Cerebromicrovasculature in Rat Stroke Model. PLoS One. 2016 Mar 14;11(3):e0149602. doi: 10.1371\/journal.pone.0149602. PMID: 26974842; PMCID:<br \/>\nPMC4790912.<\/p>\n<p>24: Tsai CY, Su CH, Leu S, Chang AY, Chan JY, Chan SH. Endogenous vascular endothelial growth factor produces tonic facilitation of cardiac vagal baroreflex via fetal liver kinase-1 in medulla oblongata. Int J Cardiol. 2015;187:421-5. doi: 10.1016\/j.ijcard.2015.03.375. Epub 2015 Mar 27. PMID: 25841140.<\/p>\n<p>25: Tsai CY, Chen CH, Chang AY, Chan JY, Chan SH. Upregulation of FLJ10540, a PI3K-association protein, in rostral ventrolateral medulla impairs brain stem cardiovascular regulation during mevinphos intoxication. Biochem Pharmacol. 2015 Jan 1;93(1):34-41. doi: 10.1016\/j.bcp.2014.10.018. Epub 2014 Nov 7. PMID: 25449601.<\/p>\n<p>26: Tsai CY, Chua S, Leu S, Chang AY, Chan JY, Chan SH. VEGF tonically sustains myocardial performance via fetal liver kinase-1 in the heart. Int J Cardiol. 2014 Dec 15;177(2):727-30. doi: 10.1016\/j.ijcard.2014.10.019. PMID: 25456694.<\/p>\n<p>27: Tsai CY, Chang AY, Chan JY, Chan SH. Activation of PI3K\/Akt signaling in rostral ventrolateral medulla impairs brain stem cardiovascular regulation that underpins circulatory depression during mevinphos intoxication. Biochem Pharmacol. 2014 Mar 1;88(1):75-85. doi: 10.1016\/j.bcp.2014.01.014. Epub 2014 Jan 22. PMID: 24462917.<\/p>\n<p>28: Tsai CY, Su CH, Baudrie V, Laude D, Weng JC, Chang AY, Chan JY, Elghozi JL, Chan SH. Visualizing oxidative stress-induced depression of cardiac vagal baroreflex by MRI\/DTI in a mouse neurogenic hypertension model. Neuroimage. 2013 Nov 15;82:190-9. doi: 10.1016\/j.neuroimage.2013.05.124. Epub 2013 Jun 6. PMID: 23747290.<\/p>\n<p>29: Tsai CY, Chan JY, Hsu KS, Chang AY, Chan SH. Brain-derived neurotrophic factor ameliorates brain stem cardiovascular dysregulation during experimental temporal lobe status epilepticus. PLoS One. 2012;7(3):e33527. doi: 10.1371\/journal.pone.0033527. Epub 2012 Mar 19. PMID: 22442695; PMCID: PMC3307740.<\/p>\n<p>30: Chan JY, Tsai CY, Wu CH, Li FC, Dai KY, Sun EY, Chan SH, Chang AY. Sumoylation of hypoxia-inducible factor-1\u03b1 ameliorates failure of brain stem cardiovascular regulation in experimental brain death. PLoS One. 2011 Mar 3;6(3):e17375. doi: 10.1371\/journal.pone.0017375. PMID: 21390240; PMCID: PMC3048406.<\/p>\n<p>31: Chou JL, Wu CH, Tsai CY, Chang AY, Chan SH. Proteomic investigation of a neural substrate intimately related to brain death. Proteomics. 2011 Jan;11(2):239-48. doi: 10.1002\/pmic.201000438. Epub 2010 Dec 17. PMID: 21204251.<\/p>\n<p>32: Chang AY, Chan JY, Cheng HL, Tsai CY, Chan SH. Hypoxia-inducible factor 1\/heme oxygenase 1 cascade as upstream signals in the prolife role of heat shock protein 70 at rostral ventrolateral medulla during experimental brain stem death. Shock. 2009 Dec;32(6):651-8. doi: 10.1097\/SHK.0b013e3181a71027. PMID: 19333137.<\/p>\n<p>33: Chan JY, Wu CH, Tsai CY, Cheng HL, Dai KY, Chan SH, Chang AY. Transcriptional up-regulation of nitric oxide synthase II by nuclear factor-kappaB at rostral ventrolateral medulla in a rat mevinphos intoxication model of brain stem death. J Physiol. 2007 Jun 15;581(Pt 3):1293-307. doi: 10.1113\/jphysiol.2007.130872. Epub 2007 Mar 29. PMID: 17395621; PMCID: PMC2170851.<\/p>\n<p>34: Tsai CY, Wu CH, Chan SH, Chang AY. Muscarinic receptor-independent activation of cyclic adenosine monophosphate-dependent protein kinase in rostral ventrolateral medulla underlies the sympathoexcitatory phase of cardiovascular responses during mevinphos intoxication in the rat. Shock. 2007 May;27(5):559-64. doi: 10.1097\/01.shk.0000246904.47766.39. PMID: 17438462.<\/p>\n<p>35: Chan JY, Chan SH, Li FC, Tsai CY, Cheng HL, Chang AY. Phasic cardiovascular responses to mevinphos are mediated through differential activation of cGMP\/PKG cascade and peroxynitrite via nitric oxide generated in the rat rostral ventrolateral medulla by NOS I and II isoforms. Neuropharmacology. 2005 Jan;48(1):161-72. doi: 10.1016\/j.neuropharm.2004.08.012. PMID: 15617736.<\/p>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-3\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-3\" class=\"tab \"  itemprop=\"headline\" ><span class='tab_icon' aria-hidden='true' data-av_icon='\ue80b' data-av_iconfont='entypo-fontello'><\/span>\u7814\u7a76\u5718\u968a<\/div>\n    <div id=\"tab-id-3-container\" class=\"tab_content \" aria-hidden=\"true\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<h4 style=\"text-align: left;\"><strong>\u00a0<\/strong><\/h4>\n<table width=\"480\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td bgcolor=\"#FFFFFF\">\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1975 size-full\" src=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/WuCC270.jpg\" alt=\"\" width=\"180\" height=\"270\" \/><\/p>\n<h3 style=\"font-size: 18px; text-align: center;\"><strong>\u5433\u5609\u7426<\/strong><\/h3>\n<h3 style=\"font-size: 16px; text-align: center;\"><strong>Wu, Jacqueline C.C.<\/strong><\/h3>\n<h5><\/h5>\n<h5 style=\"text-align: center;\">\u7814\u7a76\u52a9\u7406<br \/>\nResearch Assistant<\/h5>\n<\/td>\n<td bgcolor=\"#FFFFFF\">\n<p style=\"text-align: center;\"><a href=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2020\/02\/photo270.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-3093 size-full\" src=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2020\/02\/photo270.jpg\" alt=\"\" width=\"180\" height=\"270\" \/><\/a><\/p>\n<h3 style=\"font-size: 18px; text-align: center;\"><strong>\u674e\u771f\u4f86<\/strong><\/h3>\n<h3 style=\"font-size: 16px; text-align: center;\"><strong>Lee, Chin-Lai<\/strong><\/h3>\n<h5><\/h5>\n<h5 style=\"text-align: center;\">\u7814\u7a76\u52a9\u7406<br \/>\nResearch Assistant<\/h5>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-4\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-4\" class=\"tab \"  itemprop=\"headline\" ><span class='tab_icon' aria-hidden='true' data-av_icon='\ue840' data-av_iconfont='entypo-fontello'><\/span>\u5b78\u8853\u5c65\u6b77<\/div>\n    <div id=\"tab-id-4-container\" class=\"tab_content \" aria-hidden=\"true\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<p><strong>Education:<\/strong><\/p>\n<p>2009\u00a0 Ph.D.\u00a0 Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan<br \/>\n2004\u00a0 B.S.\u00a0 \u00a0Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan<\/p>\n<p><strong>Professional Experience:<\/strong><\/p>\n<p>2019\/8 ~ present <strong>Associate Professor<\/strong>, Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan<br \/>\n2015\/9 ~ 2019\/7\u00a0 \u00a0<strong>Assistant Professor<\/strong>, Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan<br \/>\n2009\/9 ~ 2015\/8\u00a0 \u00a0<strong>Postdoctoral Research Fellow<\/strong>, Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan<\/p>\n<p><strong>Awards and Honors: <\/strong><\/p>\n<p>2019 \u00a0\u00a0\u00a0<strong>Editorial Board Fellow<\/strong>, <em>The Journal of Physiology<\/em><br \/>\n2018\u00a0\u00a0\u00a0 <strong>Awardee<\/strong>, Chang Gung Outstanding Young Medical Researcher Award, Chang Gung Medical<br \/>\nFoundation, Kaohsiung, Taiwan (\u9577\u5e9a\u91ab\u5b78\u7814\u7a76\u734e-\u9752\u5e74\u734e)<br \/>\n2016\u00a0\u00a0\u00a0 <strong>Awardee<\/strong>, Young Investigator Award, Federation of Asian Societies for Molecular Imaging (FASMI) Annual Meeting, Kobe, Japan<br \/>\n2016\u00a0\u00a0\u00a0 <strong>Travel Grants and Oral Speaker<\/strong>, the 13th Asia Pacific Federation of Pharmacologists (APFP) Meeting, Bangkok, Thailand<br \/>\n2013\u00a0\u00a0\u00a0 <strong>Awardee<\/strong>, Outstanding Young Scientist Oral Presentation Award, the 12th meeting of the Asia Pacific Federation of Pharmacologists (APFP), Shanghai, China<br \/>\n2008\u00a0\u00a0\u00a0 <strong>Awardee<\/strong>, Distinguished Postgraduate Student Research Award, the Pharmacological Society in Taiwan, Taiwan<br \/>\n2007\u00a0\u00a0\u00a0 <strong>1st prize<\/strong>, SEAWP Poster Prize, the 10th Southeast Asian Western Pacific regional meeting of Pharmacologists (SEAWP), Adelaide, Australia<br \/>\n2006\u00a0\u00a0\u00a0 <strong>Participant<\/strong>, the 9th International Brain Research Organization-Asia Pacific Regional Committee (IBRO-APRC) School of Neuroscience, Hong Kong, China<\/p>\n<p><strong>Professional Activities:<\/strong><\/p>\n<p>2021~\u00a0 <strong>Associate Editor<\/strong>, <em>Natural Sciences<\/em><br \/>\n2019\u00a0\u00a0 \u00a0<strong>Symposium<\/strong> <strong>Organizer and Chair<\/strong>, the 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019), Kobe, Japan<br \/>\n2018~\u00a0 <strong>Editorial Board<\/strong>, <em>FASEB BioAdvances<\/em><br \/>\n2017\u00a0\u00a0\u00a0 <strong>Invited Speaker<\/strong>, Young Investigator Colloquium, the International Society for Neurochemistry (ISN) 2017 Biennial Meeting, Paris, France<br \/>\n2014\u00a0\u00a0\u00a0 <strong>Invited Speaker<\/strong>, Young Investigator Colloquium, the 12th meeting of the Asian Pacific Society for Neurochemistry (APSN), Kaohsiung, Taiwan<br \/>\n2012\u00a0\u00a0 <strong>\u00a0Invited Speaker<\/strong>, Young Investigator Colloquium, the 11th meeting of the Asian Pacific Society for Neurochemistry (APSN), Kobe, Japan<\/p>\n<p><strong>Professional Societies:<\/strong><\/p>\n<p>American Physiological Society (APS)<br \/>\nInternational Society for Neurochemistry (ISN)<br \/>\nThe Chinese Physiological Society<br \/>\nThe Pharmacological Society in Taiwan<\/p>\n<p><strong>Research Interests: <\/strong><\/p>\n<ol>\n<li>Central Cardiovascular Regulation<\/li>\n<li>Signal Transduction<\/li>\n<li>Molecular Image<\/li>\n<li>Pharmacology of pesticides and anesthetics<\/li>\n<li>Redox signaling and oxidative stress<\/li>\n<\/ol>\n\n        <\/div>\n    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