{"id":2241,"date":"2020-02-12T14:25:15","date_gmt":"2020-02-12T06:25:15","guid":{"rendered":"https:\/\/itrbm.org\/en\/?page_id=2241"},"modified":"2025-05-26T09:31:21","modified_gmt":"2025-05-26T01:31:21","slug":"tzeng-ht","status":"publish","type":"page","link":"https:\/\/itrbm.org\/en\/members\/tzeng-ht\/","title":{"rendered":"Tzeng, Hong-Tai"},"content":{"rendered":"<div id='av_section_1' class='avia-section main_color avia-section-large avia-no-border-styling avia-full-stretch av-section-color-overlay-active avia-bg-style-scroll  avia-builder-el-0  el_before_av_one_fourth  avia-builder-el-first   container_wrap sidebar_left' style='background-repeat: no-repeat; background-image: url(https:\/\/itrbm.org\/en\/wp-content\/uploads\/2019\/03\/dna-1.jpg);background-attachment: scroll; background-position: center center;  '  data-section-bg-repeat='stretch'><div class='av-section-color-overlay-wrap'><div class='av-section-color-overlay' style='opacity: 0.2; background-color: #000000; '><\/div><div class='container' ><main  role=\"main\" itemprop=\"mainContentOfPage\"  class='template-page content  av-content-small units'><div class='post-entry post-entry-type-page post-entry-2241'><div class='entry-content-wrapper clearfix'>\n<div style='padding-bottom:10px; 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'><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3><strong><span style=\"font-size: 18px; color: #109bc5;\">Hong-Tai Tzeng<\/span><\/strong><br \/>\n<span style=\"font-size: 16px; color: #333333;\">Associate Professor<\/span><\/h3>\n<h5><span style=\"color: #333333;\">Immunology<\/span><br \/>\n<span style=\"color: #333333;\">Tumor immunology<\/span><br \/>\n<span style=\"color: #333333;\">Molecular biology<\/span><br \/>\n<span style=\"color: #333333;\">Tumor biology<\/span><\/h5>\n<\/div><\/section><\/div><\/p>\n<div class=\"flex_column av_one_third  flex_column_div av-zero-column-padding   avia-builder-el-6  el_after_av_two_fifth  el_before_av_hr  \" style='border-radius:0px; '><div class='avia-icon-list-container   avia-builder-el-7  avia-builder-el-no-sibling '><ul class='avia-icon-list avia-icon-list-left av-iconlist-small avia_animate_when_almost_visible avia-iconlist-animate'>\n<li><div  style='font-size:14px; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue854' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><div class='av_iconlist_title iconlist_title_small  '  itemprop=\"headline\"   style='font-size:14px; '>Phone<\/div><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><h5>+886-7-731-7123 ext 8592<\/h5>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<li><div  style='font-size:14px; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue805' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><div class='av_iconlist_title iconlist_title_small  '  itemprop=\"headline\"   style='font-size:14px; '>Email<\/div><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><h5>htay11@cgmh.org.tw<\/h5>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<\/ul><\/div><\/div>\n<div style='height:20px' class='hr hr-invisible   avia-builder-el-8  el_after_av_one_third  el_before_av_tab_container '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div>\n<div class=\"tabcontainer   top_tab   avia-builder-el-9  el_after_av_hr  avia-builder-el-last \">\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-1\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-1\" class=\"tab active_tab\"  itemprop=\"headline\" >Research Overview<\/div>\n    <div id=\"tab-id-1-container\" class=\"tab_content active_tab_content\" aria-hidden=\"false\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<p>Interplays between tumor and immune cells in tumor microenvironment predispose to promote tumor development owing to the enhanced pro-tumoral activities and reduced anti-tumor functions. Tumor-derived signalings apparently can modulate the function of surrounding immune cells in the tumor microenvironment. For therapeutic purpose, immune checkpoint inhibitors such as antibodies against PD-1\/PD-L1 and CTLA-4, restore anti-tumor immunity and show promising clinical outcomes in treating cancer patients. However, only a small portion of patients display therapeutic response to immune checkpoint inhibitor-based therapy. Plasminogen activator inhibitor 1 (PAI-1) plays a critical role in thrombosis and atherosclerosis, and also expresses high level in types of cancer. In our study, we demonstrate the regulation of PAI-1 on surface PD-L1 of tumor cells. Blocking of PAI-1 activity promotes surface exposure of PD-L1 and enhances the availability to antiPD-L1 antibody leading to improvement of anti-PD-L1-mediated therapy.<\/p>\n<p><a href=\"https:\/\/itrbm.org\/site\/tw\/wp-content\/uploads\/2021\/07\/2021-Tzeng-Research.png\"><img decoding=\"async\" class=\"aligncenter wp-image-3472 size-portfolio\" src=\"https:\/\/itrbm.org\/site\/tw\/wp-content\/uploads\/2021\/07\/2021-Tzeng-Research.png\" alt=\"\" width=\"495\" \/><\/a><\/p>\n<p>On the other hand, in contrast to immune checkpoint inhibitor therapy, chemotherapy remains the mainstream of therapeutic strategy for cancer treatment. We also demonstrate that tumor autophagy-mediated PAI-1 secretion modulates immune cell populations in tumor microenvironment and thereby induces the resistance to chemotherapy. We continue to explore the link between tumor-derived factors and immune cell activity, and to develop novel therapeutic strategy for cancer treatment.<\/p>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-2\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-2\" class=\"tab \"  itemprop=\"headline\" >Publications<\/div>\n    <div id=\"tab-id-2-container\" class=\"tab_content \" aria-hidden=\"true\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<p><strong>Selected recent publications (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Tzeng+HT%5Bauthor%5D\" target=\"_blank\" rel=\"noopener\">Pubmed Search<\/a>)<br \/>\n<\/strong> (\u2020 Contributed equally to the article; * Correspondence author of the article)<\/p>\n<ol>\n<li>Tseng YJ, Lee CH, Chen WY, Yang JL, <strong>Tzeng HT<\/strong>*. <em>Inhibition of PAI-1 Blocks PD-L1 Endocytosis and Improves the Response of Melanoma Cells to Immune Checkpoint Blockade.<\/em> J Invest Dermatol. S0022-202X(21)01230-6 (2021).<\/li>\n<li><strong>Tzeng HT<\/strong>*, Yang JL, Tseng YJ, Lee CH, Chen WJ, Chyuan IT*. <em>Plasminogen Activator Inhibitor-1 Secretion by Autophagy Contributes to Melanoma Resistance to Chemotherapy through Tumor Microenvironment Modulation.<\/em> Cancers (Basel). 13(6):1253 (2021).<\/li>\n<li><strong>Tzeng HT<\/strong>, Chyuan IT*. <em>Immunometabolism in systemic lupus erythematosus: Relevant pathogenetic mechanisms and potential clinical applications<\/em>. J Formos Med Assoc. S0929-6646(21)00124-8 (2021).<\/li>\n<li>Chen WY, Li LC, Wu YH, Yang JL, <strong>Tzeng HT<\/strong>*. <em>Emerging Roles of Interleukin-33-responsive Kidney Group 2 Innate Lymphoid Cells in Acute Kidney Injury<\/em>. Int J Mol Sci. 21(4):1544 (2020).<\/li>\n<li><strong>Tzeng HT<\/strong>, Chyuan IT, Chen WY*. <em>Shaping of Innate Immune Response by Fatty Acid Metabolite Palmitate<\/em>. Cells. 8(12):1633 (2019).<\/li>\n<li>Wang YS<sup>\u2020<\/sup>, <strong>Tzeng HT<\/strong><sup>\u2020<\/sup>, Tsai CH, Cheng HC, Lai WW, Liu HS, Wang YC*. <em>VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function.<\/em> Cancer Lett. 28: 437:79-88 (2018).<\/li>\n<li><strong>Tzeng HT<\/strong>, Su CC, Chang CP, Lai WW, Su WC, Wang YC*. <em>Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages toward tumor-suppressing phenotype. <\/em>Int J Cancer. 143: 1753-63 (2018).<\/li>\n<li><strong>Tzeng HT<\/strong>, Li TH, Tang YA, Tsai CH, Lu PJ, Lai WW, Chiang CW, Wang YC*. <em>Phosphorylation of Rab37 by protein kinase C alpha inhibits the exocytosis function and metastasis suppression activity of Rab37.<\/em> Oncotarget, 8(65):108556-70 (2017).<\/li>\n<li><strong>Tzeng HT<\/strong><sup>\u2020<\/sup>, Tsai CH<sup>\u2020<\/sup>, Yen YT<sup>\u2020<\/sup>, Cheng HC, Chen YC, Pu SW, Wang YS, Shan YS, Tseng YL, Su WC, Lai WW, Wu LW, Wang YC*. <em>Dysregulation of Rab37-mediated cross-talk between cancer cells and endothelial cells via thrombospondin-1 promotes tumor neovasculature and metastasis<\/em>. Clin Cancer Res, 23(9):2335-2345 (2017).<\/li>\n<li><strong>Tzeng HT<\/strong>, Wang YC*. <em>Rab-mediated vesicle trafficking in cancer<\/em>. J Biomed Sci, 23(1):70 (2016).<\/li>\n<\/ol>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-3\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-3\" class=\"tab \"  itemprop=\"headline\" >Research Team<\/div>\n    <div id=\"tab-id-3-container\" class=\"tab_content \" aria-hidden=\"true\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<h4 style=\"text-align: left;\"><\/h4>\n<table style=\"table-layout: fixed;\" width=\"720\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td bgcolor=\"#FFFFFF\">\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-3093 size-full\" src=\"https:\/\/itrbm.org\/site\/tw\/wp-content\/uploads\/2020\/02\/photo270.jpg\" alt=\"\" width=\"180\" height=\"270\" \/><\/p>\n<h4 style=\"text-align: center;\"><strong>\u9673\u97cb\u5982<\/strong><\/h4>\n<h5 style=\"text-align: center;\">\u7814\u7a76\u52a9\u7406<br \/>\nResearch Assistant<\/h5>\n<\/td>\n<td bgcolor=\"#FFFFFF\">\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2057 size-full\" src=\"https:\/\/itrbm.org\/site\/tw\/wp-content\/uploads\/2019\/06\/HuangTF270.jpg\" alt=\"\" width=\"180\" height=\"270\" \/><\/p>\n<h4 style=\"text-align: center;\"><strong>\u9ec3\u7471\u82b3<\/strong><\/h4>\n<h5 style=\"text-align: center;\">\u7814\u7a76\u52a9\u7406<br \/>\nResearch Assistant<\/h5>\n<\/td>\n<td bgcolor=\"#FFFFFF\">\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-3734 size-full\" src=\"https:\/\/itrbm.org\/site\/tw\/wp-content\/uploads\/2022\/03\/HongCT_270.jpg\" alt=\"\" width=\"180\" height=\"270\" \/><\/p>\n<h4 style=\"text-align: center;\"><strong>\u6d2a\u6625\u59ff<br \/>\n<\/strong><\/h4>\n<h5 style=\"text-align: center;\">\u7814\u7a76\u52a9\u7406<br \/>\nResearch Assistant<\/h5>\n<\/td>\n<\/tr>\n<tr>\n<td bgcolor=\"#FFFFFF\">\n<h4 style=\"text-align: center;\"><strong>\u9ec3\u5b9c\u5a77<\/strong><\/h4>\n<h5 style=\"text-align: center;\">\u5de5\u8b80\u751f<br \/>\nPart-time Intern<\/h5>\n<\/td>\n<td bgcolor=\"#FFFFFF\">\n<h4 style=\"text-align: center;\"><\/h4>\n<h5 style=\"text-align: center;\"><\/h5>\n<\/td>\n<td bgcolor=\"#FFFFFF\">\n<h4 style=\"text-align: center;\"><\/h4>\n<h5 style=\"text-align: center;\"><\/h5>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-4\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-4\" class=\"tab \"  itemprop=\"headline\" >Full CV<\/div>\n    <div id=\"tab-id-4-container\" class=\"tab_content \" aria-hidden=\"true\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<p><strong>EDUCATION:<\/strong><\/p>\n<p>2007 &#8211; 2014 Ph.D.<br \/>\nGraduate Institute of Immunology, College of Medicine,<br \/>\nNational Taiwan University, Taipei, Taiwan<\/p>\n<p><strong>PROFESSIONAL EXPERIENCE:<\/strong><\/p>\n<p>2018\/8 ~ present <strong>Assistant Professor<\/strong><br \/>\nInstitute for Translational Research in Biomedicine,<br \/>\nKaohsiung Chang Gung Memorial Hospital,<br \/>\nKaohsiung, Taiwan<\/p>\n<p>2014\/8 ~ 2018\/7 <strong>Postdoctoral Research Fellow<\/strong><br \/>\nDepartment of Pharmacology, College of Medicine,<br \/>\nNational Cheng Kung University, Tainan, Taiwan<\/p>\n<p><strong>AWARDS AND RESEARCH SUPPORT:<\/strong><\/p>\n<p>2017 The third Prize (oral presentation in English), Autumn Camp 2017, The Taiwan Society for<br \/>\nBiochemistry and Molecular Biology<br \/>\n2017 The Second Prize (Thematic oral presentation), 32th Joint Annual Conference of Biomedical<br \/>\nScience (JACBS)<br \/>\n2016 The First Prize (oral presentation), 31th Annual Meeting of Toxicology Society of Taiwan<br \/>\n2016 Travel Grant, International Academic Conference, Ministry of Science and Technology<br \/>\n2012 Travel Grant, Oversea International Academic Conference, Ministry of Education<br \/>\n2012 Travel Grant, aim for the top University Project to the National Taiwan University<br \/>\n2012 Excellent paper Award (oral presentation), The Chinese Society of Immunology<br \/>\n2011 Excellent paper Award (oral presentation), The Chinese Society of Immunology<br \/>\n2010 Excellent paper Award (oral presentation), The Chinese Society of Immunology<\/p>\n<p><strong>RESEARCH INTERESTS:<\/strong><\/p>\n<p>1. Viral immunology of infectious disease<br \/>\n2. Regulation of T cell activation in cancer<br \/>\n3. Development of immunotherapy for cancer treatment<\/p>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":443,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/itrbm.org\/en\/wp-json\/wp\/v2\/pages\/2241"}],"collection":[{"href":"https:\/\/itrbm.org\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/itrbm.org\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/itrbm.org\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/itrbm.org\/en\/wp-json\/wp\/v2\/comments?post=2241"}],"version-history":[{"count":12,"href":"https:\/\/itrbm.org\/en\/wp-json\/wp\/v2\/pages\/2241\/revisions"}],"predecessor-version":[{"id":3323,"href":"https:\/\/itrbm.org\/en\/wp-json\/wp\/v2\/pages\/2241\/revisions\/3323"}],"up":[{"embeddable":true,"href":"https:\/\/itrbm.org\/en\/wp-json\/wp\/v2\/pages\/443"}],"wp:attachment":[{"href":"https:\/\/itrbm.org\/en\/wp-json\/wp\/v2\/media?parent=2241"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}