{"id":2221,"date":"2020-02-11T17:51:12","date_gmt":"2020-02-11T09:51:12","guid":{"rendered":"https:\/\/itrbm.org\/en\/?page_id=2221"},"modified":"2025-05-26T09:31:49","modified_gmt":"2025-05-26T01:31:49","slug":"wu-klh","status":"publish","type":"page","link":"https:\/\/itrbm.org\/en\/members\/wu-klh\/","title":{"rendered":"Wu, Kay L.H."},"content":{"rendered":"<div id='av_section_1' class='avia-section main_color avia-section-large avia-no-border-styling avia-full-stretch av-section-color-overlay-active avia-bg-style-scroll  avia-builder-el-0  el_before_av_one_fourth  avia-builder-el-first   container_wrap sidebar_left' style='background-repeat: no-repeat; background-image: url(https:\/\/itrbm.org\/en\/wp-content\/uploads\/2019\/03\/dna-1.jpg);background-attachment: scroll; background-position: center center;  '  data-section-bg-repeat='stretch'><div class='av-section-color-overlay-wrap'><div class='av-section-color-overlay' style='opacity: 0.2; background-color: #000000; '><\/div><div class='container' ><main  role=\"main\" itemprop=\"mainContentOfPage\"  class='template-page content  av-content-small units'><div class='post-entry post-entry-type-page post-entry-2221'><div class='entry-content-wrapper clearfix'>\n<div style='padding-bottom:10px; color:#ffffff;font-size:44px;' class='av-special-heading av-special-heading-h1 custom-color-heading blockquote modern-quote modern-centered  avia-builder-el-1  avia-builder-el-no-sibling  av-inherit-size '><h1 class='av-special-heading-tag '  itemprop=\"headline\"  >Members<\/h1><div class='special-heading-border'><div class='special-heading-inner-border' style='border-color:#ffffff'><\/div><\/div><\/div>\n<\/div><\/div><\/main><!-- close content main element --><\/div><\/div><\/div><div id='after_section_1' class='main_color av_default_container_wrap container_wrap sidebar_left' style=' '  ><div class='container' ><div class='template-page content  av-content-small units'><div class='post-entry post-entry-type-page post-entry-2221'><div class='entry-content-wrapper clearfix'>\n<div class=\"flex_column av_one_fourth  flex_column_div av-zero-column-padding first  avia-builder-el-2  el_after_av_section  el_before_av_two_fifth  avia-builder-el-first  \" style='border-radius:0px; '><div class='avia-image-container  av-styling-    avia-builder-el-3  avia-builder-el-no-sibling  avia-align-left '  itemprop=\"ImageObject\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><img class='avia_image' src='https:\/\/itrbm.org\/en\/wp-content\/uploads\/2025\/05\/9B2A2489-WuKLH_240.jpg' alt='' title='9B2A2489 WuKLH 240' height=\"240\" width=\"180\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div><\/div><div class=\"flex_column av_two_fifth  flex_column_div av-zero-column-padding   avia-builder-el-4  el_after_av_one_fourth  el_before_av_one_third  \" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3><strong><span style=\"font-size: 18px; color: #109bc5;\">Kay L.H. Wu<\/span><\/strong><br \/>\n<span style=\"font-size: 16px; color: #333333;\">Professor<\/span><\/h3>\n<h5><span style=\"color: #333333;\">Animal models of cognitive dysfunction<\/span><br \/>\n<span style=\"color: #333333;\">Animal models of autonomic neuropathy<\/span><br \/>\n<span style=\"color: #333333;\">Neuroinflammation<\/span><br \/>\n<span style=\"color: #333333;\">Adult neurogenesis<\/span><\/h5>\n<\/div><\/section><\/div><\/p>\n<div class=\"flex_column av_one_third  flex_column_div av-zero-column-padding   avia-builder-el-6  el_after_av_two_fifth  el_before_av_hr  \" style='border-radius:0px; '><div class='avia-icon-list-container   avia-builder-el-7  avia-builder-el-no-sibling '><ul class='avia-icon-list avia-icon-list-left av-iconlist-small avia_animate_when_almost_visible avia-iconlist-animate'>\n<li><div  style='font-size:14px; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue854' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><div class='av_iconlist_title iconlist_title_small  '  itemprop=\"headline\"   style='font-size:14px; '>Phone<\/div><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><h5>+886-7-731-7123 ext 8596<\/h5>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<li><div  style='font-size:14px; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue805' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><div class='av_iconlist_title iconlist_title_small  '  itemprop=\"headline\"   style='font-size:14px; '>Email<\/div><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><h5>klhwu@adm.cgmh.org.tw<\/h5>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<\/ul><\/div><\/div>\n<div style='height:20px' class='hr hr-invisible   avia-builder-el-8  el_after_av_one_third  el_before_av_tab_container '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div>\n<div class=\"tabcontainer   top_tab   avia-builder-el-9  el_after_av_hr  avia-builder-el-last \">\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-1\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-1\" class=\"tab active_tab\"  itemprop=\"headline\" >Research Overview<\/div>\n    <div id=\"tab-id-1-container\" class=\"tab_content active_tab_content\" aria-hidden=\"false\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<p>\u4e2d\u6a1e\u795e\u7d93\u56e0\u61c9\u5916\u5728\u74b0\u5883\u7684\u8b8a\u52d5\uff0c\u5f59\u6574\u4e26\u8abf\u7bc0\u500b\u9ad4\u5167\u5728\u7684\u8a0a\u606f\u4ee5\u7dad\u6301\u751f\u7406\u529f\u80fd\u7684\u6046\u5e38\u904b\u4f5c\u3002\u98f2\u98df\u662f\u500b\u9ad4\u7372\u5f97\u80fd\u91cf\u7dad\u6301\u751f\u7406\u529f\u80fd\u4e3b\u8981\u4f86\u6e90\uff0c\u904e\u5ea6\u98f2\u98df\u640d\u5bb3\u5668\u5b98\u751f\u7406\u529f\u80fd\u3002\u6211\u5011\u7684\u7814\u7a76\u4e3b\u984c\u70ba\u63a2\u8a0e\u9ad8\u7cd6\u98f2\u98df\u5f71\u97ff\u5b78\u7fd2\u8a18\u61b6\u4e2d\u6a1e\uff0c\u6d77\u99ac\u5efb\uff0c\u5c0e\u81f4\u5b78\u7fd2\u8a18\u61b6\u80fd\u529b\u7f3a\u5931\u7684\u81f4\u75c5\u6a5f\u8f49\u3002\u4e26\u900f\u904e\u52d5\u7269\u6a21\u5f0f\u7814\u7a76\u5c0b\u6c42\u81e8\u5e8a\u6cbb\u7642\u8207\u9810\u9632\u6700\u9069\u5b9c\u7684\u6642\u6a5f\u8207\u7b56\u7565\u3002\u7c92\u7dda\u9ad4\u70ba\u7d30\u80de\u80fd\u91cf\u4ee3\u8b1d\u7684\u6838\u5fc3\uff0c\u56e0\u61c9\u7d30\u80de\u5916\u7684\u71df\u990a\u6e90\u6fc3\u5ea6\u6ce2\u52d5\uff0c\u7dad\u6301\u7d30\u80de\u529f\u80fd\u3002\u56e0\u6b64\u7c92\u7dda\u9ad4\u54c1\u8cea\u63a7\u5236\u8207\u6046\u5b9a\u7dad\u6301\u53d7\u5230\u591a\u500b\u6a5f\u5236\u8abf\u63a7\uff0c\u907f\u514d\u56e0\u7c92\u7dda\u9ad4\u5931\u80fd\u9020\u6210\u7d30\u80de\u5931\u80fd\uff0c\u751a\u81f3\u6b7b\u4ea1\u3002\u6211\u5011\u7684\u7814\u7a76\u8457\u773c\u65bc\u7c92\u7dda\u9ad4\u529f\u80fd\u7684\u6046\u5b9a\u8207\u6ce2\u52d5\u56e0\u61c9\u74b0\u5883\u6539\u8b8a\u6240\u626e\u6f14\u7684\u89d2\u8272\uff0c\u4e26\u5c07\u7814\u7a76\u7406\u5ff5\u5ef6\u4f38\u81f3\u81e8\u5e8a\u61c9\u7528\uff0c\u8207\u81e8\u5e8a\u91ab\u5e2b\u5408\u4f5c\u63a2\u8a0e\u5152\u7ae5\u6025\u6027\u5fc3\u81df\u8870\u7aed\u4ee5\u53ca\u6162\u6027\u767c\u708e\u5f15\u8d77\u8166\u4e2d\u98a8\u7684\u6a5f\u8f49\u8207\u6cbb\u7642\u6548\u76ca\u3002<\/p>\n<h5><strong>\u7814\u7a76\u4e3b\u984c\u4e00<\/strong><\/h5>\n<h5><strong>\u63a2\u8a0e\u74b0\u5883\u8207\u9ad8\u679c\u7cd6\u98f2\u98df\u5f71\u97ff\u5b50\u4ee3\u5b78\u7fd2\u8207\u8a18\u61b6\u7684\u6a5f\u8f49<\/strong><\/h5>\n<p>\u7d93\u7531\u61f7\u5b55\u53ca\u54fa\u4e73\u671f\u9935\u98df\u9ad8\u7cd6\u98f2\u98df\u7684\u52d5\u7269\u6a21\u5f0f\uff0c\u6211\u5011\u8b49\u5be6\u5b50\u4ee3\u5b78\u7fd2\u8207\u8a18\u61b6\u80fd\u529b\u53d7\u640d\u3002\u7531\u74b0\u5883\u8c50\u5bcc\u5316\u523a\u6fc0\uff0c\u5b50\u4ee3\u5b78\u7fd2\u8207\u8a18\u61b6\u80fd\u529b\u53ef\u56de\u5fa9\u6b63\u5e38\u3002\u5176\u4e2d\u4e00\u500b\u91cd\u8981\u7684\u56e0\u7d20\u70ba\u661f\u72c0\u81a0\u7d30\u80de\u7684\u80fd\u91cf\u4ee3\u8b1d\u529f\u80fd\u53d7\u6291\u5236\u800c\u9650\u5236\u661f\u72c0\u81a0\u7d30\u80de-\u795e\u7d93\u5143\u4ee3\u8b1d\u5076\u5408\u6548\u61c9\uff0c\u9032\u800c\u5f71\u97ff\u795e\u7d93\u6d3b\u6027\u3002<\/p>\n<p><a href=\"https:\/\/itrbm.org\/site\/tw\/wp-content\/uploads\/2019\/06\/BDNF.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2083\" src=\"https:\/\/itrbm.org\/site\/tw\/wp-content\/uploads\/2019\/06\/BDNF.jpg\" alt=\"\" width=\"400\" height=\"167\" \/><\/a><\/p>\n<h5><strong>\u7814\u7a76\u4e3b\u984c\u4e8c<\/strong><\/h5>\n<h5><strong>\u63a2\u8a0e\u74b0\u5883\u8207\u9ad8\u679c\u7cd6\u98f2\u98df\u5f71\u97ff\u500b\u9ad4\u5b78\u7fd2\u8207\u8a18\u61b6\u7684\u6a5f\u8f49<\/strong><\/h5>\n<p>\u6211\u5011\u8b49\u5be6\u7d93\u7531\u9935\u98df\u9ad8\u679c\u7cd6\u98f2\u98df\u7684\u52d5\u7269\u6a21\u5f0f\uff0c\u9020\u6210\u500b\u9ad4\u5b78\u7fd2\u8207\u8a18\u61b6\u80fd\u529b\u53d7\u640d\u3002\u9ad8\u679c\u7cd6\u98f2\u98df\u7fd2\u6163\u7d93\u7531\u5f15\u8d77\u795e\u7d93\u767c\u708e\uff0c\u964d\u4f4e\u7a81\u89f8\u53ef\u5851\u6027\u4ee5\u53ca\u6291\u5236\u65b0\u751f\u9020\u6210\u5b78\u7fd2\u8207\u8a18\u61b6\u80fd\u529b\u53d7\u640d\u3002\u5176\u4e2d\uff0c\u8178\u9053\u83cc\u76f8\u5931\u8861\u626e\u6f14\u91cd\u8981\u89d2\u8272\u3002<\/p>\n<h5><strong>\u5408\u4f5c\u7814\u7a76\u4e3b\u984c\u4e00<\/strong><\/h5>\n<h5><strong>\u63a2\u8a0e\u6025\u6027\u6b63\u814e\u4e0a\u817a\u7d20\u4e0a\u5347\u5f71\u97ff\u5152\u7ae5\u5fc3\u80ba\u529f\u80fd\u7684\u6a5f\u8f49\u53ca\u81e8\u5e8a\u7528\u85e5\u6548\u76ca\u7684\u8a55\u4f30<\/strong><\/h5>\n<p>\u6211\u5011\u8207\u5152\u7ae5\u5167\u79d1\u6797\u5b9c\u541b\u526f\u90e8\u9577\u5408\u4f5c\u4ee5\u6025\u6027\u6b63\u814e\u4e0a\u817a\u7d20 (norepinephrine, NE) \u4e0a\u5347\u7684\u52d5\u7269\u6a21\u5f0f\uff0c\u6a21\u64ec\u8178\u75c5\u6bd2 71 \u578b\u5f15\u8d77\u6025\u6027\u5fc3\u81df\u8870\u7aed\u7684\u75c7\u72c0\uff0c\u7814\u7a76\u5fc3\u80ba\u7d30\u80de\u56e0\u61c9\u6025\u6027\u6b63\u814e\u4e0a\u817a\u7d20\u4e0a\u5347\uff0c\u6539\u8b8a\u7d30\u80de\u5206\u5b50\u7684\u751f\u7406\u529f\u80fd\u4e26\u5f71\u97ff\u81e8\u5e8a\u7528\u85e5\u7684\u53cd\u61c9\u7528\u4ee5\u63d0\u9ad8\u6cbb\u7642\u6210\u6548\u3002<\/p>\n<p><a href=\"https:\/\/itrbm.org\/site\/tw\/wp-content\/uploads\/2019\/06\/NE.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2084\" src=\"https:\/\/itrbm.org\/site\/tw\/wp-content\/uploads\/2019\/06\/NE.png\" alt=\"\" width=\"350\" height=\"117\" \/><\/a><\/p>\n<h5><strong>\u5408\u4f5c\u7814\u7a76\u4e3b\u984c\u4e8c<\/strong><\/h5>\n<h5><strong>\u63a2\u8a0e\u767c\u708e\u5f71\u97ff\u8166\u8840\u7ba1\u81ea\u4e3b\u8abf\u63a7\u7684\u6a5f\u8f49\u53ca\u5c0d\u8166\u4e2d\u98a8\u9810\u5f8c\u7684\u5f71\u97ff<\/strong><\/h5>\n<p>\u6211\u5011\u8207\u8166\u8840\u7ba1\u79d1\u5085\u7766\u60e0\u91ab\u5e2b\u5408\u4f5c\u4ee5\u8166\u4e2d\u98a8\u7684\u52d5\u7269\u6a21\u5f0f\uff0c\u63a2\u7d22\u8166\u4e2d\u98a8\u5f71\u97ff\u8166\u8840\u7ba1\u81ea\u4e3b\u8abf\u63a7\uff0c\u6539\u8b8a\u795e\u7d93\u751f\u7406\u529f\u80fd\u7684\u6a5f\u8f49\u4e26\u767c\u5c55\u65b0\u8208\u7642\u6cd5\u63d0\u9ad8\u6cbb\u7642\u6548\u76ca\u3002<\/p>\n<p><a href=\"https:\/\/itrbm.org\/site\/tw\/wp-content\/uploads\/2019\/06\/SGLT.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2085\" src=\"https:\/\/itrbm.org\/site\/tw\/wp-content\/uploads\/2019\/06\/SGLT.png\" alt=\"\" width=\"350\" height=\"97\" \/><\/a><\/p>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-2\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-2\" class=\"tab \"  itemprop=\"headline\" >Publications<\/div>\n    <div id=\"tab-id-2-container\" class=\"tab_content \" aria-hidden=\"true\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<p><strong>Selected recent publications (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Wu%2C+Kay+L.H.%5Bauthor%5D\" target=\"_blank\" rel=\"noopener\">Pubmed Search<\/a>)<br \/>\n<\/strong>\u00a0(\u2020 Contributed equally to the article; * Correspondence author of the article)<\/p>\n<ol>\n<li>Huang HM, Chang YC, Lee JJ, Huang YS, <strong>Wu KLH<\/strong>*. \u03c9-3 PUFAs Ameliorated the Maternal High-Fructose Diet-Induced Early-Onset Retinopathy in Offspring via Inhibiting NLRP3-Associated Neuroinflammation. (2024) Mol Nutr Food Res. 24:e2400135.<\/li>\n<li>Lin IC, <strong>Wu KLH<\/strong>, Cheng HH, Tsai CC, Yu HR, Hsu TY, Tain YL, Huang LT, Lai YJ. Association of Perinatal Cardiovascular Features with Angiotensin System Expressions in Maternal Preeclampsia. (2024) Int J Mol Sci. 25(13):7426.<\/li>\n<li><strong>Wu KLH<\/strong>*, Liu WC, Wu CW, Fu MH, Huang HM, Tain YL, Liang CK, Hung CY, Chen IC, Hung PL, Lin YJ, Hirase H. Butyrate reduction and HDAC4 increase underlie maternal high fructose-induced metabolic dysfunction in hippocampal astrocytes in female rats. (2024) J Nutr Biochem. 126:109571.<\/li>\n<li><strong>Wu KLH<\/strong>*, Wu CW, Chen LW, Chang HH, Cheng CL, Wu CY, Lee YC, Chen IC, Hung CY, Liu WC. Dysregulation of mitochondrial dynamics mediated aortic perivascular adipose tissue-associated vascular reactivity impairment under excessive fructose intake. (2024) Nutr Metab (Lond). 21(1):4.<\/li>\n<li>Bai LY, <strong>Wu KLH<\/strong>, Chiu CF, Chao HC, Lin WY, Hu JL, Peng BR, Weng JR. Extract of Ficus septica modulates apoptosis and migration in human oral squamous cell carcinoma cells. (2023) Environ Toxicol. 38(3):666-675.<\/li>\n<li>Liu WC, Wu CW, Fu MH, Tain YL, Liang CK, Chen IC, Hung CY, Lee YC, <strong>Wu KLH<\/strong>*. Lipopolysaccharide-induced Autophagy Increases SOX2-positive Astrocytes While Decreasing Neuronal Differentiation in the Adult Hippocampus. (2022) Exp Neurobiol. 31(5):307-323.<\/li>\n<li>Weng JR, Wu CW, Chen YC, Fu MF, Tain YL, Hung CY, Chen IC, Lee CW, <strong>Wu KLH*<\/strong>. Fructose milieu undermines the therapeutic effect of Tribulus terrestris Extract on neuroblastoma cell line via maintaining mitochondrial function. (2022) Environmental Toxicology. doi: 10.1002\/tox.23632.<\/li>\n<li>Lee WC, <strong>Wu KLH<\/strong>, Tain YL, Leu S, Cheng YT, Chan JYH*. Impaired insulin signaling at the bladder mucosa facilitates metabolic syndrome-associated bladder overactivity in rats with maternal and post-weaning fructose exposure. (2022) J Formos Med Assoc. Oct 4:S0929-6646(22)00363-1. doi: 10.1016\/j.jfma.2022.09.013.<\/li>\n<li>Lin IC*, Wu CW, Lin YJ, Lo MH, Hsieh KS, Chan JYH and <strong>Wu KLH*<\/strong>. Milrinone effects on cardiac mitochondria, hemodynamics, and death in catecholamine-infused rats. (2022) Pediatric Research. doi: 10.1038\/s41390-022-01964-6.<\/li>\n<li>Chang HH, Lin IC, Wu CW, Hung CY, Liu WC, Wu CY, Cheng CL*, <strong>Wu KLH*<\/strong>. High fructose induced osteogenic differentiation of human valve interstitial cells via activating PI3K\/AKT\/mitochondria signaling. (2022) Biomedical Journal. 45(3):491-503.<\/li>\n<li>Huang HM, Wu CW, Chen IC, Lee YC, Huang YS, Hung CY, <strong>Wu KLH*<\/strong>. Maternal high fructose diet induced early onset retinopathy via the suppression of synaptic plasticity mediated by the mitochondrial dysfunction. (2021) Am J Physiol Endocrinol Metab. 320(6):E1173-E1182.<\/li>\n<li>Liu WC, Wu CW, Hung PL, Chan JYH, Tain YL, Fu MH, Chen LW, Liang CK, Hung CY, Yu HR, Chen IC, <strong>Wu KLH*<\/strong>. (2020) Environmental stimulation counteracts the suppressive effects of maternal high fructose diet on cell proliferation and neuronal differentiation in the dentate gyrus of adult female offspring via histone deacetylase 4. Int J Environ Res Public Health. 81:108378.<\/li>\n<li>Chao YM, <strong>Wu KLH<\/strong>, Tsai PC, Tain YL, Leu S, Lee WC, Chan JYH*. (2020) Anomalous AMPK-regulated Angiotensin AT 1 R Expression and SIRT1-mediated Mitochondrial Biogenesis at RVLM in Hypertension Programming of Offspring to Maternal High Fructose Exposure. J Biomed Sci. 27(1):68.<\/li>\n<li>Liu WC, Wu CW, Fu MH, Tain YL, Liang CK, Hung CY, Chen IC, Lee YC, Wu CY and <strong>Wu KLH*<\/strong>. (2020) Maternal high fructose-induced hippocampal neuroinflammation in the adult female offspring via PPARg-NF-kB signaling. J Nutr Biochem 81:108378.<\/li>\n<li>Fu MH, Chen IC, Lee CH, Wu CW, Lee YC, Kung YC, Hung CY, <strong>Wu KLH*<\/strong>. (2019) Anti-neuroinflammation ameliorates systemic inflammation-induced mitochondrial DNA impairment in the nucleus of the solitary tract and cardiovascular reflex dysfunction. J Neuroinflammation. 16(1):224.<\/li>\n<li>Lin IC, Wu CW, Tain YL, Chen IC, Hung CY, <strong>Wu KLH*<\/strong>. (2019) High fructose diet-induced early mortality via autophagy factors accumulation in the rostral ventrolateral medulla is ameliorated by Pioglitazone. J Nutr Biochem. 69:87-97<em>.<\/em><\/li>\n<li>Suwanjang W*, <strong>Wu KLH<\/strong>, Prachayasittikul S, Chetsawang B, Charngkaew K. (2019) Mitochondrial Dynamics Impairment in Dexamethasone-Treated Neuronal Cells. Neurochem Res. 44:1567-1581.<\/li>\n<li>Wu CW, Hung CY, Hirase H, Tain YL, Lee WC, Chan JYH, Fu MH, Chen LW, Liu WC, Liang CK, Ho YH, Kung YC, Leu S,<strong> Wu KLH*<\/strong>. (2019) Pioglitazone reversed the fructose-programmed astrocytic glycolysis and oxidative phosphorylation of female rat offspring. Am J Physiol Endocrinol Metab. 16:E622-E634.<\/li>\n<\/ol>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-3\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-3\" class=\"tab \"  itemprop=\"headline\" >Research Team<\/div>\n    <div id=\"tab-id-3-container\" class=\"tab_content \" aria-hidden=\"true\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<h4 style=\"text-align: left;\"><\/h4>\n<table style=\"table-layout: fixed;\" width=\"720\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td bgcolor=\"#FFFFFF\">\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-2096 size-full alignnone\" src=\"https:\/\/itrbm.org\/site\/tw\/wp-content\/uploads\/2019\/06\/HongCY240.jpg\" alt=\"\" width=\"180\" height=\"240\" \/><\/p>\n<h4 style=\"text-align: center;\"><strong>\u6d2a\u7d14\u745b<\/strong><\/h4>\n<h5 style=\"text-align: center;\">\u7814\u7a76\u52a9\u7406<br \/>\nResearch Assistant<\/h5>\n<\/td>\n<td bgcolor=\"#FFFFFF\">\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-3094 size-full\" src=\"https:\/\/itrbm.org\/site\/tw\/wp-content\/uploads\/2020\/02\/photo240.jpg\" alt=\"\" width=\"180\" height=\"240\" \/><\/p>\n<h4 style=\"text-align: center;\"><strong>\u9673\u6021\u541b<\/strong><\/h4>\n<h5 style=\"text-align: center;\">\u7814\u7a76\u52a9\u7406<br \/>\nResearch Assistant<\/h5>\n<\/td>\n<td bgcolor=\"#FFFFFF\">\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-3094 size-full\" src=\"https:\/\/itrbm.org\/site\/tw\/wp-content\/uploads\/2020\/02\/photo240.jpg\" alt=\"\" width=\"180\" height=\"240\" \/><\/p>\n<h4 style=\"text-align: center;\"><strong>\u674e\u80b2\u7dba<\/strong><\/h4>\n<h5 style=\"text-align: center;\">\u7814\u7a76\u52a9\u7406<br \/>\nResearch Assistant<\/h5>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h5><\/h5>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-3078 size-full\" src=\"https:\/\/itrbm.org\/site\/tw\/wp-content\/uploads\/2020\/02\/TeamLin500.jpg\" alt=\"\" width=\"500\" height=\"282\" \/><br \/>\n<strong>\u6797\u5b9c\u541b\u526f\u90e8\u9577\u7814\u7a76\u5718\u968a<\/strong><\/p>\n<h5><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-3079 size-full\" src=\"https:\/\/itrbm.org\/site\/tw\/wp-content\/uploads\/2020\/02\/TeamFu500.jpg\" alt=\"\" width=\"500\" height=\"282\" \/><br \/>\n<strong>\u5085\u7766\u60e0\u91ab\u5e2b\u7814\u7a76\u5718\u968a<\/strong><\/h5>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-4\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-4\" class=\"tab \"  itemprop=\"headline\" >Full CV<\/div>\n    <div id=\"tab-id-4-container\" class=\"tab_content \" aria-hidden=\"true\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<h4>Education<\/h4>\n<table>\n<tbody>\n<tr>\n<td width=\"110\"><strong>2002-2007<\/strong><\/td>\n<td width=\"468\"><strong>Ph D<\/strong><\/p>\n<p>The Graduate Institute of Medicine, Kaohsiung Medical University, Taiwan, R.O.C.<\/td>\n<\/tr>\n<tr>\n<td width=\"110\"><strong>1997-1999<\/strong><\/td>\n<td width=\"468\"><strong>M. S. (June, 1999)<\/strong><\/p>\n<p>Institute of Physiology in National Yang-Ming University, Taiwan, R.O.C.<\/td>\n<\/tr>\n<tr>\n<td width=\"110\"><strong>1992-1997<\/strong><\/td>\n<td width=\"468\"><strong>D.V.M. (June, 1997)<\/strong><\/p>\n<p>College of Veterinary Medicine in National Chung-Hsing University, Taiwan, R.O.C.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h4><strong>Honors<\/strong><\/h4>\n<table>\n<tbody>\n<tr>\n<td width=\"110\"><strong>2019<\/strong><\/td>\n<td width=\"468\">Invited speaker of Physiology Speaker Travel Agenda of LSUHSC<\/td>\n<\/tr>\n<tr>\n<td width=\"110\"><strong>2018<\/strong><\/td>\n<td width=\"468\">2018 Frontiers in Translational Medicine invited speaker<\/td>\n<\/tr>\n<tr>\n<td width=\"110\"><strong>2017<\/strong><\/td>\n<td width=\"468\">BIT&#8217;s 9th Annual International Congress of Cardiology-2017 (ICC-2017) invited speaker and Co-chair<\/td>\n<\/tr>\n<tr>\n<td width=\"110\"><strong>2017<\/strong><\/td>\n<td width=\"468\">International Conference on Diabetes and its Complications 2017 (ICDC 2017) invited speaker (Poster Section)<\/td>\n<\/tr>\n<tr>\n<td width=\"110\"><strong>2015<\/strong><\/td>\n<td width=\"468\">30th Annual Conference of Biomedical Sciences-Physiology invited speaker<\/td>\n<\/tr>\n<tr>\n<td width=\"110\"><strong>2013<\/strong><\/td>\n<td width=\"468\">IUPS 2013 Travel Awards.<br \/>\nThe title of my presentation was: Fructose increases ATP-and ROS-dependent neurotransmitter release<\/td>\n<\/tr>\n<tr>\n<td width=\"110\"><strong>2011<\/strong><\/td>\n<td width=\"468\">Young Investigator Award of the 7<sup>th<\/sup> FAOPS Congress.<\/p>\n<p>The title of my presentation was: cyclooxygenase-2-dependent neuroinflammation and oxidative stress in rostral ventrolateral medulla contribute to neurogenic hypertension following peripheral inflammation<\/td>\n<\/tr>\n<tr>\n<td width=\"110\"><strong>2006<\/strong><\/td>\n<td width=\"468\">Distinguished Neuroscience Award of Taiwan Neuroscience Society Annual Meeting International Stroke Symposium, Taiwan.<\/p>\n<p>The title of my presentation was: <em>Superoxide anion- and nitric oxide-dependent mitochondrial dysfunction in neuronal apoptosis after spinal cord injury<\/em><\/p>\n<p>The second runner up poster presentation of the 21th annual Meeting of Biological sciences, Taiwan.<\/p>\n<p>The title of my presentation was: <em>Superoxide anion- and nitric oxide-associated mitochondrial dysfunction in neuronal apoptosis after spinal cord injury<\/em><\/td>\n<\/tr>\n<tr>\n<td width=\"110\"><strong>2005-<\/strong><\/td>\n<td width=\"468\">The member of International Brain Research Organization (IBRO)<\/td>\n<\/tr>\n<tr>\n<td width=\"110\"><strong>2003-2006<\/strong><\/td>\n<td width=\"468\">Outstanding Graduated Students in the Graduate program of Medicine, Kaohsiung Medicine University.<\/td>\n<\/tr>\n<tr>\n<td width=\"110\"><strong>2000<\/strong><\/td>\n<td width=\"468\">The best poster presentation of the Neuroscience Meeting 2000, Taiwan. The title of my presentation was:<br \/>\n<em>Neuronal apoptosis in pontine reticular formation after spinal cord transection and the protection by brain-derived neuro-trophic factor<\/em>.<\/td>\n<\/tr>\n<tr>\n<td width=\"110\"><strong>1997-1999<\/strong><\/td>\n<td width=\"468\">Outstanding Graduated Students Scholarship Supported by Ministry of Education<\/td>\n<\/tr>\n<tr>\n<td width=\"110\"><strong>1994<\/strong><\/td>\n<td width=\"468\">The best poster presentation of the Fourth Symposium on Recent Advances in Cellular and Molecular Biology, Taiwan. The title of my presentation was:<br \/>\n<em>Analysis of unregulated cellular genes in pseudorabies virus infection: use of mRNA differential display<\/em><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h4>Research Experiences<\/h4>\n<ul>\n<li><strong>Aug, 2021-<\/strong><\/li>\n<\/ul>\n<p><strong>Name of Institute:<\/strong><\/p>\n<p>Institute for Translational Research in Biomedine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, Republic of China.<\/p>\n<p><strong>Job Title:<\/strong> <em>Professor (Hospital)\/ Associate Professor (College)<\/em><\/p>\n<ul>\n<li><strong>Aug, 2015-July, 2021<\/strong><\/li>\n<\/ul>\n<p><strong>Name of Institute:<\/strong><\/p>\n<p>Institute for Translational Research in Biomedine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, Republic of China.<\/p>\n<p><strong>Job Title:<\/strong> <em>Associate Professor (Hospital)\/ Assistant Professor (College)<\/em><\/p>\n<ul>\n<li><strong>June, 2011-2015<\/strong><\/li>\n<\/ul>\n<p><strong>Name of Institute:<\/strong><\/p>\n<p>Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, Republic of China.<\/p>\n<p><strong>Job Title:<\/strong> <em>Assistant Professor<\/em><\/p>\n<ul>\n<li><strong>September, 2008- May, 2011<\/strong><\/li>\n<\/ul>\n<p><strong>Name of Institute:<\/strong><\/p>\n<p>Neural Structure &amp; Function Research Laboratory, Department of Medical Education and Research,<\/p>\n<p>Veterans General Hospital-Kaohsiung.<\/p>\n<p><strong>Job Title: <\/strong>postdoctoral fellow<\/p>\n<p><strong>Supervisor:<\/strong> Prof. Julie Y. H. Chan<\/p>\n<ul>\n<li><strong>September, 2007-2008<\/strong><\/li>\n<\/ul>\n<p><strong>Name of Institute:<\/strong><\/p>\n<p>Center for Neuroscience, National Sun Yat-sen University.<\/p>\n<p><strong>Job Title: <\/strong>postdoctoral fellow<\/p>\n<p><strong>Supervisor:<\/strong> Prof. Samuel H. H. Chan<\/p>\n<ul>\n<li><strong>September, 2002-2007<\/strong><\/li>\n<\/ul>\n<p><strong>Name of Institute:<\/strong><\/p>\n<ol>\n<li>The Graduate Institute of Medicine, Kaohsiung Medical University.<\/li>\n<li>Neural Structure &amp; Function Research Laboratory, Department of Medical Education and Research, Veterans General Hospital-Kaohsiung.<\/li>\n<\/ol>\n<p><strong>Job Title: <\/strong>Ph D student<\/p>\n<p><strong>Supervisor:<\/strong> Prof. Julie Y. H. Chan and Prof. Chin Hsu<\/p>\n<ul>\n<li><strong>September, 1999 \u20132002<\/strong><\/li>\n<\/ul>\n<p><strong>Name of Institute:<\/strong><\/p>\n<p>Neural Structure &amp; Function Research Laboratory, Department of Medical Education and Research,<br \/>\nVeterans General Hospital-Kaohsiung.<\/p>\n<p><strong>Job Title: <\/strong>Research technologist<\/p>\n<p><strong>Supervisor:<\/strong> Prof. Julie Y. H. Chan<\/p>\n<p><strong>Project<\/strong><\/p>\n<p>Protective role of brain-derived neurotrophic factor in neuronal cell death of pontine reticular formation after spinal cord injury.<\/p>\n<ul>\n<li><strong>March, 1993 \u20131997<\/strong><\/li>\n<\/ul>\n<p><strong>Name of Institute:<br \/>\n<\/strong>Molecular Biology &amp; Veterinary Virology Laboratory,<br \/>\nCollege of Veterinary Medicine,<br \/>\nNational Chung-Hsing University.<\/p>\n<p><strong>Job Title: <\/strong>Research technologist<\/p>\n<p><strong>Supervisor:<\/strong> Dr. Tien-Jye Chang<\/p>\n<p><strong>Project<\/strong><\/p>\n<ol>\n<li>Study of early genes on pseudorabies virus expression, gene regulation, and biological functions.<\/li>\n<li>Construction of a gene-deleted mutant or a replication-deficient virus as an expression vector for foreign genes or a live virus vaccine.<\/li>\n<\/ol>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":443,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/itrbm.org\/en\/wp-json\/wp\/v2\/pages\/2221"}],"collection":[{"href":"https:\/\/itrbm.org\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/itrbm.org\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/itrbm.org\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/itrbm.org\/en\/wp-json\/wp\/v2\/comments?post=2221"}],"version-history":[{"count":12,"href":"https:\/\/itrbm.org\/en\/wp-json\/wp\/v2\/pages\/2221\/revisions"}],"predecessor-version":[{"id":3325,"href":"https:\/\/itrbm.org\/en\/wp-json\/wp\/v2\/pages\/2221\/revisions\/3325"}],"up":[{"embeddable":true,"href":"https:\/\/itrbm.org\/en\/wp-json\/wp\/v2\/pages\/443"}],"wp:attachment":[{"href":"https:\/\/itrbm.org\/en\/wp-json\/wp\/v2\/media?parent=2221"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}