{"id":2193,"date":"2020-02-10T17:49:52","date_gmt":"2020-02-10T09:49:52","guid":{"rendered":"https:\/\/itrbm.org\/en\/?page_id=2193"},"modified":"2025-06-30T16:45:36","modified_gmt":"2025-06-30T08:45:36","slug":"tsai-cy","status":"publish","type":"page","link":"https:\/\/itrbm.org\/en\/members\/tsai-cy\/","title":{"rendered":"Tsai, Ching-Yi"},"content":{"rendered":"<div id='av_section_1' class='avia-section main_color avia-section-large avia-no-border-styling avia-full-stretch av-section-color-overlay-active avia-bg-style-scroll  avia-builder-el-0  el_before_av_one_fourth  avia-builder-el-first   container_wrap sidebar_left' style='background-repeat: no-repeat; background-image: url(https:\/\/itrbm.org\/en\/wp-content\/uploads\/2019\/03\/dna-1.jpg);background-attachment: scroll; background-position: center center;  '  data-section-bg-repeat='stretch'><div class='av-section-color-overlay-wrap'><div class='av-section-color-overlay' style='opacity: 0.2; background-color: #000000; '><\/div><div class='container' ><main  role=\"main\" itemprop=\"mainContentOfPage\"  class='template-page content  av-content-small units'><div class='post-entry post-entry-type-page post-entry-2193'><div class='entry-content-wrapper clearfix'>\n<div style='padding-bottom:10px; color:#ffffff;font-size:44px;' class='av-special-heading av-special-heading-h1 custom-color-heading blockquote modern-quote modern-centered  avia-builder-el-1  avia-builder-el-no-sibling  av-inherit-size '><h1 class='av-special-heading-tag '  itemprop=\"headline\"  >Members<\/h1><div class='special-heading-border'><div class='special-heading-inner-border' style='border-color:#ffffff'><\/div><\/div><\/div>\n<\/div><\/div><\/main><!-- close content main element --><\/div><\/div><\/div><div id='after_section_1' class='main_color av_default_container_wrap container_wrap sidebar_left' style=' '  ><div class='container' ><div class='template-page content  av-content-small units'><div class='post-entry post-entry-type-page post-entry-2193'><div class='entry-content-wrapper clearfix'>\n<div class=\"flex_column av_one_fourth  flex_column_div av-zero-column-padding first  avia-builder-el-2  el_after_av_section  el_before_av_two_fifth  avia-builder-el-first  \" style='border-radius:0px; '><div class='avia-image-container  av-styling-    avia-builder-el-3  avia-builder-el-no-sibling  avia-align-left '  itemprop=\"ImageObject\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><img class='avia_image' src='https:\/\/itrbm.org\/en\/wp-content\/uploads\/2025\/05\/9B2A2561-TsaiCY_240.jpg' alt='' title='9B2A2561 TsaiCY 240' height=\"240\" width=\"180\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div><\/div>\n<div class=\"flex_column av_two_fifth  flex_column_div av-zero-column-padding   avia-builder-el-4  el_after_av_one_fourth  el_before_av_one_third  \" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3><strong><span style=\"font-size: 18px; color: #109bc5;\">Ching-Yi Tsai<\/span><\/strong><br \/>\n<span style=\"font-size: 16px; color: #333333;\">Associate Professor<\/span><\/h3>\n<h5><span style=\"color: #333333;\">Central cardiovascular regulation<\/span><br \/>\n<span style=\"color: #333333;\">Signal transduction<\/span><br \/>\n<span style=\"color: #333333;\">Molecular image<\/span><br \/>\n<span style=\"color: #333333;\">Pharmacology of pesticides and anesthetics<\/span><br \/>\n<span style=\"color: #333333;\">Redox signaling and oxidative stress<\/span><\/h5>\n<\/div><\/section><\/div>\n<div class=\"flex_column av_one_third  flex_column_div av-zero-column-padding   avia-builder-el-6  el_after_av_two_fifth  el_before_av_hr  \" style='border-radius:0px; '><div class='avia-icon-list-container   avia-builder-el-7  avia-builder-el-no-sibling '><ul class='avia-icon-list avia-icon-list-left av-iconlist-small avia_animate_when_almost_visible avia-iconlist-animate'>\n<li><div  style='font-size:14px; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue854' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><div class='av_iconlist_title iconlist_title_small  '  itemprop=\"headline\"   style='font-size:14px; '>Phone<\/div><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><h5>+886-7-731-7123 ext 8598<\/h5>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<li><div  style='font-size:14px; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue805' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><div class='av_iconlist_title iconlist_title_small  '  itemprop=\"headline\"   style='font-size:14px; '>Email<\/div><\/header><div class='iconlist_content  '  itemprop=\"text\"  ><h5>cytsai@cgmh.org.tw<\/h5>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<\/ul><\/div><\/div>\n<div style='height:20px' class='hr hr-invisible   avia-builder-el-8  el_after_av_one_third  el_before_av_tab_container '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div>\n<div class=\"tabcontainer   top_tab   avia-builder-el-9  el_after_av_hr  avia-builder-el-last \">\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-1\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-1\" class=\"tab active_tab\"  itemprop=\"headline\" >Research Overview<\/div>\n    <div id=\"tab-id-1-container\" class=\"tab_content active_tab_content\" aria-hidden=\"false\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<h4><strong>Unravel cellular and molecular mechanisms of brainstem regulation of cardiovascular functions in health and disease<\/strong><\/h4>\n<p>Our research interests are primarily on signaling cascades and neural circuits involved in brainstem cardiovascular regulation associated with brainstem death, neurogenic hypertension and hepatic encephalopathy. Our approach is to integrate cellular and molecular biology into systemic physiology using clinically-relevant animal models. In recent years, we have expanded her research horizons on brainstem cardiovascular regulation to image changes in functional connectivity between key brainstem nuclei involved in the baroreflex circuits of mice and rats, and showed that these changes bear physiological, pathophysiological and pathological meaning.<\/p>\n<h5><strong>1. Proposed cellular mechanisms at the RVLM in the mevinphos-intoxication model of brainstem death.<\/strong><\/h5>\n<p>Activation of PI3K\/Akt signaling in the RVLM via upregulation of the NF-\u03baB\/NOS II\/peroxynitrite cascade that leads to impairment of the baroreflex-mediated sympathetic vasomotor tone and loss of the \u201clife-and-death\u201d signals that underpins experimental brainstem death. Upregulation of FLJ10540, a PI3K-association protein, which is upstream to activation of PI3K\/Akt signaling cascade, elicits circulatory depression. On the other hand, augmented PTEN activity via decreasing its oxidized form sustains brain stem cardiovascular regulatory function during experimental brain stem death as a negative regulator of PI3K\/Akt signaling in the RVLM.<br \/>\n(<em>Biochem Pharmacol.<\/em> 2018 Sep; 155:207-212.)<\/p>\n<p><a href=\"https:\/\/itrbm.org\/site\/tw\/wp-content\/uploads\/2019\/06\/FLJ10540.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1950\" src=\"https:\/\/itrbm.org\/site\/tw\/wp-content\/uploads\/2019\/06\/FLJ10540.jpg\" alt=\"\" width=\"500\" height=\"144\" \/><\/a><\/p>\n<h5><strong>2. We also combined molecular imaging with our physiological evaluation of brainstem cardiovascular regulation using diffusion tensor imaging (DTI) to detect functional connectivity between key brainstem nuclei involved in the baroreflex circuit. <\/strong><\/h5>\n<p>Under pathophysiological conditions when the disruption of the functional connectivity is reversible, the associated disease condition (e.g. neurogenic hypertension) is amenable to remedial measurements. However, fatality ensues when pathophysiological conditions evolve to pathological conditions (e.g. hepatic encephalopathy) when the functional connectivity is irreversibly severed. (<em>J Physiol.<\/em> 2019 Jan; 597(1):41-55.)<\/p>\n<p><a href=\"https:\/\/itrbm.org\/site\/tw\/wp-content\/uploads\/2019\/06\/DTI.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1949\" src=\"https:\/\/itrbm.org\/site\/tw\/wp-content\/uploads\/2019\/06\/DTI.jpg\" alt=\"\" width=\"450\" height=\"296\" \/><\/a><\/p>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-2\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-2\" class=\"tab \"  itemprop=\"headline\" >Publications<\/div>\n    <div id=\"tab-id-2-container\" class=\"tab_content \" aria-hidden=\"true\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<p><strong>Selected recent publications (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Ching-Yi+Tsai&#091;author&#093;\" target=\"_blank\" rel=\"noopener\">Pubmed Search<\/a>)<br \/>\n<\/strong> (\u2020 Contributed equally to the article; * Correspondence author of the article)<\/p>\n<ol>\n<li><strong>Tsai CY*<\/strong>, Lee CL, Wu JCC. <em>Astrocyte-secreted lipocalin-2 elicits bioenergetic failure-induced neuronal death that is causally related to high fatality in a mouse model of hepatic encephalopathy.<\/em> Neurochem Int 178, 105800 (2024).<\/li>\n<li><strong>Tsai CY*<\/strong>, Wu JCC, Wu CJ, Chan SHH. <em>Protective role of VEGF\/VEGFR2 signaling against high fatality associated with hepatic encephalopathy via sustaining mitochondrial bioenergetics functions.<\/em> J Biomed Sci 29(1): 47 (2022).<\/li>\n<li><strong>Tsai CY*<\/strong>, Fang C, Wu JCC, Wu CJ, Dai KY, Chen SM. <em>Neuroin\ufb02ammation and microglial activation at rostral ventrolateral medulla underpin cadmium-induced cardiovascular dysregulation in rats.<\/em> Journal of Inflammation Research 14, 3863-3877 (2021).<\/li>\n<li>Poon YY<sup>\u2020<\/sup>, <strong>Tsai CY<sup>\u2020<\/sup><\/strong>, Huang YH, Wu JCC, Chan SHH, Chan JYH. <em>Disproportional cardiovascular depressive effects of isoflurane: Serendipitous findings from a comprehensive re-visit in mice.<\/em> Lab Anim (NY) 50, 26-31 (2021).<\/li>\n<li><strong>Tsai CY*<\/strong>, Wu CJ, Wu JCC, Fang C, Huang YH, Dai KY. <em>Redox-active DJ-1 sustains brainstem cardiovascular regulation via maintenance of mitochondrial function during mevinphos intoxication.<\/em> Neurochem Int 139, 104791 (2020).<\/li>\n<li>Chen SM, Phuagkhaopong S, Fang C, Wu JCC, Huang YH, Vivithanaporn P, Lin HH,<strong> Tsai CY<\/strong>*. <em>Dose-dependent acute circulatory fates elicited by cadmium are mediated by differential engagements of cardiovascular regulatory mechanisms in brain.<\/em> Frontiers in Physiology 10, 772 (2019).<\/li>\n<li><strong>Tsai CY<\/strong>, Poon YY, Chan JYH, Chan SHH.<em> Baroreflex functionality in the eye of diffusion tensor imaging<\/em>. The Journal of Physiology 597, 41-55 (2019).<\/li>\n<li><strong>Tsai CY*<\/strong>, Dai KY, Fang C, Wu JCC, Chan SHH*. <em>PTEN\/FLJ10540\/PI3K\/Akt cascade in experimental brain stem death: A newfound role for a classical tumorigenic signaling.<\/em> Biochemical Pharmacology, 155, 207-212 (2018).<\/li>\n<li><strong>Tsai CY<\/strong>*, Wu JCC, Fang C, Chang AYW. <em>PTEN, a negative regulator of PI3K\/Akt signaling, sustains brain stem cardiovascular regulation during mevinphos intoxication.<\/em> Neuropharmacology 123: 175-185 (2017).<\/li>\n<li><strong>Tsai CY<\/strong>, Su CH, Chan JYH, Chan SHH*. <em>Nitrosative stress-induced disruption of baroreflex neural circuits in a rat model of hepatic encephalopathy: a DTI study.<\/em> Scientific Reports, 7: 40111 (2017).<\/li>\n<li><strong>Tsai CY<\/strong>, Li FCH, Wu CHY, Chang AYW*, Chan SHH*. <em>Sumoylation of I\u03baB attenuates NF-\u03baB-induced nitrosative stress at rostral ventrolateral medulla and cardiovascular depression in experimental brain death.<\/em> Journal of Biomedical Science, 23: 65 (2016).<\/li>\n<li><strong>Tsai CY<\/strong><sup>\u2020<\/sup>, Chen CH<sup>\u2020<\/sup>, Chang AYW, Chan JYH, Chan SHH*. <em>Upregulation of FLJ10540, a PI3K-association protein, in rostral ventrolateral medulla impairs brain stem cardiovascular regulation during mevinphos intoxication. <\/em>Biochemical Pharmacology, 93: 34-41 (2015).<\/li>\n<\/ol>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-3\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-3\" class=\"tab \"  itemprop=\"headline\" >Research Team<\/div>\n    <div id=\"tab-id-3-container\" class=\"tab_content \" aria-hidden=\"true\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<h4 style=\"text-align: left;\"><\/h4>\n<table width=\"480\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td bgcolor=\"#FFFFFF\">\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1975 size-full\" src=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2019\/06\/WuCC270.jpg\" alt=\"\" width=\"180\" height=\"270\" \/><\/p>\n<h3 style=\"font-size: 18px; text-align: center;\"><strong>\u5433\u5609\u7426<\/strong><\/h3>\n<h3 style=\"font-size: 16px; text-align: center;\"><strong>Wu, Jacqueline C.C.<\/strong><\/h3>\n<h5><\/h5>\n<h5 style=\"text-align: center;\">\u7814\u7a76\u52a9\u7406<br \/>\nResearch Assistant<\/h5>\n<\/td>\n<td bgcolor=\"#FFFFFF\">\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1976 size-full\" src=\"https:\/\/itrbm.org\/tw\/wp-content\/uploads\/2020\/02\/photo270.jpg\" alt=\"\" width=\"180\" height=\"270\" \/><\/p>\n<h3 style=\"font-size: 18px; text-align: center;\"><strong>\u674e\u771f\u4f86<\/strong><\/h3>\n<h3 style=\"font-size: 16px; text-align: center;\"><strong>Lee, Chin-Lai<\/strong><\/h3>\n<h5><\/h5>\n<h5 style=\"text-align: center;\">\u7814\u7a76\u52a9\u7406<br \/>\nResearch Assistant<\/h5>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<section class=\"av_tab_section\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" >    <div aria-controls=\"tab-id-4\" role=\"tab\" tabindex=\"0\" data-fake-id=\"#tab-id-4\" class=\"tab \"  itemprop=\"headline\" >Full CV<\/div>\n    <div id=\"tab-id-4-container\" class=\"tab_content \" aria-hidden=\"true\">\n        <div class=\"tab_inner_content invers-color\"  itemprop=\"text\" >\n<p><strong>Education:<\/strong><\/p>\n<p>2009 Ph.D. Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan<br \/>\n2004 B.S. Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan<\/p>\n<p><strong>Professional Experience:<\/strong><\/p>\n<p>2019\/8 ~ present <strong>Associate Professor<\/strong>, Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan<br \/>\n2015\/9 ~ 2019\/7 <strong>Assistant Professor<\/strong>, Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan<br \/>\n2009\/9 ~ 2015\/8 <strong>Postdoctoral Research Fellow<\/strong>, Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan<\/p>\n<p><strong>Awards and Honors: <\/strong><\/p>\n<p>2019 <strong>Editorial Board Fellow<\/strong>, <em>The Journal of Physiology<\/em><br \/>\n2018 <strong>Awardee<\/strong>, Chang Gung Outstanding Young Medical Researcher Award, Chang Gung Medical<br \/>\nFoundation, Kaohsiung, Taiwan (\u9577\u5e9a\u91ab\u5b78\u7814\u7a76\u734e-\u9752\u5e74\u734e)<br \/>\n2016 <strong>Awardee<\/strong>, Young Investigator Award, Federation of Asian Societies for Molecular Imaging (FASMI) Annual Meeting, Kobe, Japan<br \/>\n2016 <strong>Travel Grants and Oral Speaker<\/strong>, the 13th Asia Pacific Federation of Pharmacologists (APFP) Meeting, Bangkok, Thailand<br \/>\n2013 <strong>Awardee<\/strong>, Outstanding Young Scientist Oral Presentation Award, the 12th meeting of the Asia Pacific Federation of Pharmacologists (APFP), Shanghai, China<br \/>\n2008 <strong>Awardee<\/strong>, Distinguished Postgraduate Student Research Award, the Pharmacological Society in Taiwan, Taiwan<br \/>\n2007 <strong>1st prize<\/strong>, SEAWP Poster Prize, the 10th Southeast Asian Western Pacific regional meeting of Pharmacologists (SEAWP), Adelaide, Australia<br \/>\n2006 <strong>Participant<\/strong>, the 9th International Brain Research Organization-Asia Pacific Regional Committee (IBRO-APRC) School of Neuroscience, Hong Kong, China<\/p>\n<p><strong>Professional Activities:<\/strong><\/p>\n<p>2021~ <strong>Associate Editor<\/strong>, <em>Natural Sciences<\/em><br \/>\n2019 <strong>Symposium<\/strong> <strong>Organizer and Chair<\/strong>, the 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019), Kobe, Japan<br \/>\n2018~ <strong>Editorial Board<\/strong>, <em>FASEB BioAdvances<\/em><br \/>\n2017 <strong>Invited Speaker<\/strong>, Young Investigator Colloquium, the International Society for Neurochemistry (ISN) 2017 Biennial Meeting, Paris, France<br \/>\n2014 <strong>Invited Speaker<\/strong>, Young Investigator Colloquium, the 12th meeting of the Asian Pacific Society for Neurochemistry (APSN), Kaohsiung, Taiwan<br \/>\n2012 <strong> Invited Speaker<\/strong>, Young Investigator Colloquium, the 11th meeting of the Asian Pacific Society for Neurochemistry (APSN), Kobe, Japan<\/p>\n<p><strong>Professional Societies:<\/strong><\/p>\n<p>American Physiological Society (APS)<br \/>\nInternational Society for Neurochemistry (ISN)<br \/>\nThe Chinese Physiological Society<br \/>\nThe Pharmacological Society in Taiwan<\/p>\n<p><strong>Research Interests: <\/strong><\/p>\n<ol>\n<li>Central Cardiovascular Regulation<\/li>\n<li>Signal Transduction<\/li>\n<li>Molecular Image<\/li>\n<li>Pharmacology of pesticides and anesthetics<\/li>\n<li>Redox signaling and oxidative stress<\/li>\n<\/ol>\n\n        <\/div>\n    <\/div>\n<\/section>\n\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":443,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/itrbm.org\/en\/wp-json\/wp\/v2\/pages\/2193"}],"collection":[{"href":"https:\/\/itrbm.org\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/itrbm.org\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/itrbm.org\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/itrbm.org\/en\/wp-json\/wp\/v2\/comments?post=2193"}],"version-history":[{"count":16,"href":"https:\/\/itrbm.org\/en\/wp-json\/wp\/v2\/pages\/2193\/revisions"}],"predecessor-version":[{"id":3335,"href":"https:\/\/itrbm.org\/en\/wp-json\/wp\/v2\/pages\/2193\/revisions\/3335"}],"up":[{"embeddable":true,"href":"https:\/\/itrbm.org\/en\/wp-json\/wp\/v2\/pages\/443"}],"wp:attachment":[{"href":"https:\/\/itrbm.org\/en\/wp-json\/wp\/v2\/media?parent=2193"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}